Neuroscience

Definition

Neuroscience is a multidisciplinary science that is concerned with the study of the structure and function of the nervous system. It encompasses the evolution, development, cellular and molecular biology, physiology, anatomy and pharmacology of the nervous system, as well as computational, behavioural and cognitive neuroscience.

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Latest Research and Reviews

  • Research |

    Preventing netrin secretion from floor-plate cells at the midline does not disrupt axonal guidance; commissural axons develop normally and the data suggest that netrin may influence axons locally by promoting growth cone adhesion.

    • Chloé Dominici
    • , Juan Antonio Moreno-Bravo
    • , Sergi Roig Puiggros
    • , Quentin Rappeneau
    • , Nicolas Rama
    • , Pauline Vieugue
    • , Agns Bernet
    • , Patrick Mehlen
    •  & Alain Chédotal
  • Research |

    The polyglutamine domain in ataxin 3, which is expanded in spinocerebellar ataxia type 3, allows normal ataxin 3 to interact with and deubiquitinate beclin 1 and thereby to promote autophagy.

    • Avraham Ashkenazi
    • , Carla F. Bento
    • , Thomas Ricketts
    • , Mariella Vicinanza
    • , Farah Siddiqi
    • , Mariana Pavel
    • , Ferdinando Squitieri
    • , Maarten C. Hardenberg
    • , Sara Imarisio
    • , Fiona M. Menzies
    •  & David C. Rubinsztein
  • Research |

    Human pluripotent stem cells were used to develop dorsal and ventral forebrain 3D spheroids, which can be assembled to study interneuron migration and to derive a functionally integrated forebrain system with cortical interneurons and glutamatergic neurons.

    • Fikri Birey
    • , Jimena Andersen
    • , Christopher D. Makinson
    • , Saiful Islam
    • , Wu Wei
    • , Nina Huber
    • , H. Christina Fan
    • , Kimberly R. Cordes Metzler
    • , Georgia Panagiotakos
    • , Nicholas Thom
    • , Nancy A. O’Rourke
    • , Lars M. Steinmetz
    • , Jonathan A. Bernstein
    • , Joachim Hallmayer
    • , John R. Huguenard
    •  & Sergiu P. Paşca
  • Research |

    Long-term cultures of human brain organoids display a high degree of cellular diversity, mature spontaneous neuronal networks and are sensitive to light.

    • Giorgia Quadrato
    • , Tuan Nguyen
    • , Evan Z. Macosko
    • , John L. Sherwood
    • , Sung Min Yang
    • , Daniel R. Berger
    • , Natalie Maria
    • , Jorg Scholvin
    • , Melissa Goldman
    • , Justin P. Kinney
    • , Edward S. Boyden
    • , Jeff W. Lichtman
    • , Ziv M. Williams
    • , Steven A. McCarroll
    •  & Paola Arlotta
  • Reviews |

    The consequences of spinal cord injury are often severe and irreversible; cell transplantation has emerged as a potential treatment. In this Review, the authors highlight mechanisms through which cell transplantation is thought to promote functional improvements and the obstacles to making cell transplantation a viable therapy.

    • Peggy Assinck
    • , Greg J Duncan
    • , Brett J Hilton
    • , Jason R Plemel
    •  & Wolfram Tetzlaff
    Nature Neuroscience 20, 637–647

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