Neuroscience

Definition

Neuroscience is a multidisciplinary science that is concerned with the study of the structure and function of the nervous system. It encompasses the evolution, development, cellular and molecular biology, physiology, anatomy and pharmacology of the nervous system, as well as computational, behavioural and cognitive neuroscience.

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Latest Research and Reviews

  • Research |

    Brain-region-specific RNA-seq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females, with little overlap.

    • Benoit Labonté
    • , Olivia Engmann
    • , Immanuel Purushothaman
    • , Caroline Menard
    • , Junshi Wang
    • , Chunfeng Tan
    • , Joseph R Scarpa
    • , Gregory Moy
    • , Yong-Hwee E Loh
    • , Michael Cahill
    • , Zachary S Lorsch
    • , Peter J Hamilton
    • , Erin S Calipari
    • , Georgia E Hodes
    • , Orna Issler
    • , Hope Kronman
    • , Madeline Pfau
    • , Aleksandar L J Obradovic
    • , Yan Dong
    • , Rachael L Neve
    • , Scott Russo
    • , Andrew Kazarskis
    • , Carol Tamminga
    • , Naguib Mechawar
    • , Gustavo Turecki
    • , Bin Zhang
    • , Li Shen
    •  & Eric J Nestler
  • Research |

    How GABAergic interneurons regulate segregation and integration among pyramidal cells to separate brain networks remains unclear. In this study, the authors show that subsets of chandelier cells in prelimbic area mediate directional inhibitory control of both local pyramidal neuron ensembles and global cortical subnetworks.

    • Jiangteng Lu
    • , Jason Tucciarone
    • , Nancy Padilla-Coreano
    • , Miao He
    • , Joshua A Gordon
    •  & Z Josh Huang
  • Research |

    The amygdala central nucleus (CeA) has been implicated in feeding regulation, but the underlying circuit mechanisms are incompletely understood. The authors show, in mice, that GABAergic serotonin receptor 2a–expressing CeA neurons are active during eating and promote positive reinforcement and food consumption, partly through long-range inhibition of the parabrachial nucleus.

    • Amelia M Douglass
    • , Hakan Kucukdereli
    • , Marion Ponserre
    • , Milica Markovic
    • , Jan Gründemann
    • , Cornelia Strobel
    • , Pilar L Alcala Morales
    • , Karl-Klaus Conzelmann
    • , Andreas Lüthi
    •  & Rüdiger Klein
  • Research |

    FreemoVR is a virtual reality system for freely moving animals. The versatile platform is demonstrated in various experiments with Drosophila, zebrafish, and mice.

    • John R Stowers
    • , Maximilian Hofbauer
    • , Renaud Bastien
    • , Johannes Griessner
    • , Peter Higgins
    • , Sarfarazhussain Farooqui
    • , Ruth M Fischer
    • , Karin Nowikovsky
    • , Wulf Haubensak
    • , Iain D Couzin
    • , Kristin Tessmar-Raible
    •  & Andrew D Straw
  • Reviews |

    Recent microbiome genome-wide association studies have identified numerous associations between human genetic variants and the gut microbiome. Here, the authors review how genetic variation in the host can alter the composition of the gut microbiome towards a disease state, with a focus on disorders of immunity and metabolism.

    • Andrew Brantley Hall
    • , Andrew C. Tolonen
    •  & Ramnik J. Xavier

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