The blood–brain barrier acts as a strict control point for what can enter the brain, and is created by tight junctions between endothelial cells lining blood vessels, astroyctic endfeet and a basement membrane. The ability to cross the blood–brain barrier must be considered for drugs administered peripherally, but whose target lies inside the brain.
Latest Research and Reviews
News and Comment
Research Highlights |Nature Reviews Drug Discovery 15, 84–85
News and Views |Nature Neuroscience 18, 477–478