The blood–brain barrier acts as a strict control point for what can enter the brain, and is created by tight junctions between endothelial cells lining blood vessels, astroyctic endfeet and a basement membrane. The ability to cross the blood–brain barrier must be considered for drugs administered peripherally, but whose target lies inside the brain.
Latest Research and Reviews
Research |Nature 544, 488–492
News and Comment
Research Highlights |Nature Reviews Drug Discovery 15, 84–85
News and Views |Nature Neuroscience 18, 477–478
Research Highlights |Nature Reviews Drug Discovery 14, 14–15