Neural circuits

Definition

Latest Research and Reviews

  • Research |

    Path-length-dependent axonal synapse sorting of local presynaptic axons of excitatory neurons in the rat medial entorhinal cortex results in sequential targeting of inhibitory and excitatory neurons, which are connected by a cellular feedforward inhibition circuit.

    • Helene Schmidt
    • , Anjali Gour
    • , Jakob Straehle
    • , Kevin M. Boergens
    • , Michael Brecht
    •  & Moritz Helmstaedter
  • Research | | open

    Slow oscillations between cortical Up and Down states are a defining feature of deep sleep, but their function is not well understood. Here the authors study Up/Down states in acute slices of entorhinal cortex, and find that Up states promote the weakening of subthreshold synaptic inputs, while suprathreshold inputs are preserved or strengthened.

    • Julian Bartram
    • , Martin C. Kahn
    • , Simon Tuohy
    • , Ole Paulsen
    • , Tony Wilson
    •  & Edward O. Mann
  • Research | | open

    Active locomotion requires closed-loop sensorimotor co ordination between perception and action. Here the authors show using behavioural, imaging and modelling approaches that gaze orientation during phototaxis behaviour in larval zebrafish is related to oscillatory dynamics of a neuronal population in the hindbrain.

    • Sébastien Wolf
    • , Alexis M. Dubreuil
    • , Tommaso Bertoni
    • , Urs Lucas Böhm
    • , Volker Bormuth
    • , Raphaël Candelier
    • , Sophia Karpenko
    • , David G. C. Hildebrand
    • , Isaac H. Bianco
    • , Rémi Monasson
    •  & Georges Debrégeas
  • Research |

    A small population of brainstem noradrenaline neurons powerfully modulates global brain function, but how they regulate diverse—and at times opposing—functions is not clear. The authors report that a modular organization in this neuromodulatory system, coupled with context-dependent activation modes, controls the balance between opposing emotional and flexible learning states.

    • Akira Uematsu
    • , Bao Zhen Tan
    • , Edgar A Ycu
    • , Jessica Sulkes Cuevas
    • , Jenny Koivumaa
    • , Felix Junyent
    • , Eric J Kremer
    • , Ilana B Witten
    • , Karl Deisseroth
    •  & Joshua P Johansen
  • Research |

    The authors identify the midcingulate cortex as a region that gates nociceptive plasticity without modulating basal nociception or the affective component of acute pain in mice. They identify a novel pathway from the midcingulate cortex to the posterior insula that recruits descending serotonergic projections to facilitate nociception.

    • Linette Liqi Tan
    • , Patric Pelzer
    • , Céline Heinl
    • , Wannan Tang
    • , Vijayan Gangadharan
    • , Herta Flor
    • , Rolf Sprengel
    • , Thomas Kuner
    •  & Rohini Kuner
  • Research |

    Esr1+ cells in the VMHvl are well known to influence female sexual behaviors. Here the authors find a surprising new role of this population in female aggression. They further reveal that the female VMHvl contains two molecularly and anatomically distinct subdivisions: one for aggression and one for sex.

    • Koichi Hashikawa
    • , Yoshiko Hashikawa
    • , Robin Tremblay
    • , Jiaxing Zhang
    • , James E Feng
    • , Alexander Sabol
    • , Walter T Piper
    • , Hyosang Lee
    • , Bernardo Rudy
    •  & Dayu Lin

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