Featured Content

  • World View |

    Science needs to develop ways and means to support the checking of data, says Keith Baggerly.

    • Keith Baggerly

  • Article |

    A ‘mouse atlas’, comprising single-cell transcriptomic data from more than 100,000 cells from 20 organs and tissues, has been created as a resource for cell biology.

    • Nicholas Schaum
    • , Jim Karkanias
    • , Norma F. Neff
    • , Andrew P. May
    • , Stephen R. Quake
    • , Tony Wyss-Coray
    • , Spyros Darmanis
    • , Joshua Batson
    • , Olga Botvinnik
    • , Michelle B. Chen
    • , Steven Chen
    • , Foad Green
    • , Robert C. Jones
    • , Ashley Maynard
    • , Lolita Penland
    • , Angela Oliveira Pisco
    • , Rene V. Sit
    • , Geoffrey M. Stanley
    • , James T. Webber
    • , Fabio Zanini
    • , Ankit S. Baghel
    • , Isaac Bakerman
    • , Ishita Bansal
    • , Daniela Berdnik
    • , Biter Bilen
    • , Douglas Brownfield
    • , Corey Cain
    • , Michelle B. Chen
    • , Steven Chen
    • , Min Cho
    • , Giana Cirolia
    • , Stephanie D. Conley
    • , Spyros Darmanis
    • , Aaron Demers
    • , Kubilay Demir
    • , Antoine de Morree
    • , Tessa Divita
    • , Haley du Bois
    • , Laughing Bear Torrez Dulgeroff
    • , Hamid Ebadi
    • , F. Hernán Espinoza
    • , Matt Fish
    • , Qiang Gan
    • , Benson M. George
    • , Astrid Gillich
    • , Foad Green
    • , Geraldine Genetiano
    • , Xueying Gu
    • , Gunsagar S. Gulati
    • , Yan Hang
    • , Shayan Hosseinzadeh
    • , Albin Huang
    • , Tal Iram
    • , Taichi Isobe
    • , Feather Ives
    • , Robert C. Jones
    • , Kevin S. Kao
    • , Guruswamy Karnam
    • , Aaron M. Kershner
    • , Bernhard M. Kiss
    • , William Kong
    • , Maya E. Kumar
    • , Jonathan Y. Lam
    • , Davis P. Lee
    • , Song E. Lee
    • , Guang Li
    • , Qingyun Li
    • , Ling Liu
    • , Annie Lo
    • , Wan-Jin Lu
    • , Anoop Manjunath
    • , Andrew P. May
    • , Kaia L. May
    • , Oliver L. May
    • , Ashley Maynard
    • , Marina McKay
    • , Ross J. Metzger
    • , Marco Mignardi
    • , Dullei Min
    • , Ahmad N. Nabhan
    • , Norma F. Neff
    • , Katharine M. Ng
    • , Joseph Noh
    • , Rasika Patkar
    • , Weng Chuan Peng
    • , Lolita Penland
    • , Robert Puccinelli
    • , Eric J. Rulifson
    • , Nicholas Schaum
    • , Shaheen S. Sikandar
    • , Rahul Sinha
    • , Rene V. Sit
    • , Krzysztof Szade
    • , Weilun Tan
    • , Cristina Tato
    • , Krissie Tellez
    • , Kyle J. Travaglini
    • , Carolina Tropini
    • , Lucas Waldburger
    • , Linda J. van Weele
    • , Michael N. Wosczyna
    • , Jinyi Xiang
    • , Soso Xue
    • , Justin Youngyunpipatkul
    • , Fabio Zanini
    • , Macy E. Zardeneta
    • , Fan Zhang
    • , Lu Zhou
    • , Ishita Bansal
    • , Steven Chen
    • , Min Cho
    • , Giana Cirolia
    • , Spyros Darmanis
    • , Aaron Demers
    • , Tessa Divita
    • , Hamid Ebadi
    • , Geraldine Genetiano
    • , Foad Green
    • , Shayan Hosseinzadeh
    • , Feather Ives
    • , Annie Lo
    • , Andrew P. May
    • , Ashley Maynard
    • , Marina McKay
    • , Norma F. Neff
    • , Lolita Penland
    • , Rene V. Sit
    • , Weilun Tan
    • , Lucas Waldburger
    • , Justin Youngyunpipatkul
    • , Joshua Batson
    • , Olga Botvinnik
    • , Paola Castro
    • , Derek Croote
    • , Spyros Darmanis
    • , Joseph L. DeRisi
    • , Jim Karkanias
    • , Angela Oliveira Pisco
    • , Geoffrey M. Stanley
    • , James T. Webber
    • , Fabio Zanini
    • , Ankit S. Baghel
    • , Isaac Bakerman
    • , Joshua Batson
    • , Biter Bilen
    • , Olga Botvinnik
    • , Douglas Brownfield
    • , Michelle B. Chen
    • , Spyros Darmanis
    • , Kubilay Demir
    • , Antoine de Morree
    • , Hamid Ebadi
    • , F. Hernán Espinoza
    • , Matt Fish
    • , Qiang Gan
    • , Benson M. George
    • , Astrid Gillich
    • , Xueying Gu
    • , Gunsagar S. Gulati
    • , Yan Hang
    • , Albin Huang
    • , Tal Iram
    • , Taichi Isobe
    • , Guruswamy Karnam
    • , Aaron M. Kershner
    • , Bernhard M. Kiss
    • , William Kong
    • , Christin S. Kuo
    • , Jonathan Y. Lam
    • , Benoit Lehallier
    • , Guang Li
    • , Qingyun Li
    • , Ling Liu
    • , Wan-Jin Lu
    • , Dullei Min
    • , Ahmad N. Nabhan
    • , Katharine M. Ng
    • , Patricia K. Nguyen
    • , Rasika Patkar
    • , Weng Chuan Peng
    • , Lolita Penland
    • , Eric J. Rulifson
    • , Nicholas Schaum
    • , Shaheen S. Sikandar
    • , Rahul Sinha
    • , Krzysztof Szade
    • , Serena Y. Tan
    • , Krissie Tellez
    • , Kyle J. Travaglini
    • , Carolina Tropini
    • , Linda J. van Weele
    • , Bruce M. Wang
    • , Michael N. Wosczyna
    • , Jinyi Xiang
    • , Hanadie Yousef
    • , Lu Zhou
    • , Joshua Batson
    • , Olga Botvinnik
    • , Steven Chen
    • , Spyros Darmanis
    • , Foad Green
    • , Andrew P. May
    • , Ashley Maynard
    • , Angela Oliveira Pisco
    • , Stephen R. Quake
    • , Nicholas Schaum
    • , Geoffrey M. Stanley
    • , James T. Webber
    • , Tony Wyss-Coray
    • , Fabio Zanini
    • , Philip A. Beachy
    • , Charles K. F. Chan
    • , Antoine de Morree
    • , Benson M. George
    • , Gunsagar S. Gulati
    • , Yan Hang
    • , Kerwyn Casey Huang
    • , Tal Iram
    • , Taichi Isobe
    • , Aaron M. Kershner
    • , Bernhard M. Kiss
    • , William Kong
    • , Guang Li
    • , Qingyun Li
    • , Ling Liu
    • , Wan-Jin Lu
    • , Ahmad N. Nabhan
    • , Katharine M. Ng
    • , Patricia K. Nguyen
    • , Weng Chuan Peng
    • , Eric J. Rulifson
    • , Nicholas Schaum
    • , Shaheen S. Sikandar
    • , Rahul Sinha
    • , Krzysztof Szade
    • , Kyle J. Travaglini
    • , Carolina Tropini
    • , Bruce M. Wang
    • , Kenneth Weinberg
    • , Michael N. Wosczyna
    • , Sean M. Wu
    • , Hanadie Yousef
    • , Ben A. Barres
    • , Philip A. Beachy
    • , Charles K. F. Chan
    • , Michael F. Clarke
    • , Spyros Darmanis
    • , Kerwyn Casey Huang
    • , Jim Karkanias
    • , Seung K. Kim
    • , Mark A. Krasnow
    • , Maya E. Kumar
    • , Christin S. Kuo
    • , Andrew P. May
    • , Ross J. Metzger
    • , Norma F. Neff
    • , Roel Nusse
    • , Patricia K. Nguyen
    • , Thomas A. Rando
    • , Justin Sonnenburg
    • , Bruce M. Wang
    • , Kenneth Weinberg
    • , Irving L. Weissman
    • , Sean M. Wu
    • , Stephen R. Quake
    •  & Tony Wyss-Coray

Current Issue |

Volume 562 Issue 7725

Latest Research

  • Letter |

    By intercalating large ammonium molecules to exfoliate MoS2 with preservation of the 2H-phase, highly uniform solutionprocessable 2D semiconductor nanosheets are obtained for the scalable fabrication of large-area thin-film electronics.

    • Zhaoyang Lin
    • , Yuan Liu
    • , Udayabagya Halim
    • , Mengning Ding
    • , Yuanyue Liu
    • , Yiliu Wang
    • , Chuancheng Jia
    • , Peng Chen
    • , Xidong Duan
    • , Chen Wang
    • , Frank Song
    • , Mufan Li
    • , Chengzhang Wan
    • , Yu Huang
    •  & Xiangfeng Duan

  • Letter |

    The transcription factor OTX2 ensures that germline induction is initially kept in check and only proceeds after OTX2 downregulation.

    • Jingchao Zhang
    • , Man Zhang
    • , Dario Acampora
    • , Matúš Vojtek
    • , Detian Yuan
    • , Antonio Simeone
    •  & Ian Chambers

  • Letter |

    Observations of teraelectronvolt γ-rays accelerated by the jets of the miniature quasar SS 433 are reported.

    • A. U. Abeysekara
    • , A. Albert
    • , R. Alfaro
    • , C. Alvarez
    • , J. D. Álvarez
    • , R. Arceo
    • , J. C. Arteaga-Velázquez
    • , D. Avila Rojas
    • , H. A. Ayala Solares
    • , E. Belmont-Moreno
    • , S. Y. BenZvi
    • , C. Brisbois
    • , K. S. Caballero-Mora
    • , T. Capistrán
    • , A. Carramiñana
    • , S. Casanova
    • , M. Castillo
    • , U. Cotti
    • , J. Cotzomi
    • , S. Coutiño de León
    • , C. De León
    • , E. De la Fuente
    • , J. C. Díaz-Vélez
    • , S. Dichiara
    • , B. L. Dingus
    • , M. A. DuVernois
    • , R. W. Ellsworth
    • , K. Engel
    • , C. Espinoza
    • , K. Fang
    • , H. Fleischhack
    • , N. Fraija
    • , A. Galván-Gámez
    • , J. A. García-González
    • , F. Garfias
    • , A. González-Muñoz
    • , M. M. González
    • , J. A. Goodman
    • , Z. Hampel-Arias
    • , J. P. Harding
    • , S. Hernandez
    • , J. Hinton
    • , B. Hona
    • , F. Hueyotl-Zahuantitla
    • , C. M. Hui
    • , P. Hüntemeyer
    • , A. Iriarte
    • , A. Jardin-Blicq
    • , V. Joshi
    • , S. Kaufmann
    • , P. Kar
    • , G. J. Kunde
    • , R. J. Lauer
    • , W. H. Lee
    • , H. León Vargas
    • , H. Li
    • , J. T. Linnemann
    • , A. L. Longinotti
    • , G. Luis-Raya
    • , R. López-Coto
    • , K. Malone
    • , S. S. Marinelli
    • , O. Martinez
    • , I. Martinez-Castellanos
    • , J. Martínez-Castro
    • , J. A. Matthews
    • , P. Miranda-Romagnoli
    • , E. Moreno
    • , M. Mostafá
    • , A. Nayerhoda
    • , L. Nellen
    • , M. Newbold
    • , M. U. Nisa
    • , R. Noriega-Papaqui
    • , J. Pretz
    • , E. G. Pérez-Pérez
    • , Z. Ren
    • , C. D. Rho
    • , C. Rivière
    • , D. Rosa-González
    • , M. Rosenberg
    • , E. Ruiz-Velasco
    • , F. Salesa Greus
    • , A. Sandoval
    • , M. Schneider
    • , H. Schoorlemmer
    • , M. Seglar Arroyo
    • , G. Sinnis
    • , A. J. Smith
    • , R. W. Springer
    • , P. Surajbali
    • , I. Taboada
    • , O. Tibolla
    • , K. Tollefson
    • , I. Torres
    • , G. Vianello
    • , L. Villaseñor
    • , T. Weisgarber
    • , F. Werner
    • , S. Westerhoff
    • , J. Wood
    • , T. Yapici
    • , G. Yodh
    • , A. Zepeda
    • , H. Zhang
    •  & H. Zhou

  • Letter |

    This approach introduces an aryl substituent to the α-carbon of amino acids without a transition-metal catalyst, and uses the inherent chirality of the amino acid itself as the source of asymmetry.

    • Daniel J. Leonard
    • , John W. Ward
    •  & Jonathan Clayden

  • Letter |

    Crystal structures of DltB, a bacterial membrane-bound O-acyltransferase, are reported both alone and in complex with the d-alanyl donor protein DltC.

    • Dan Ma
    • , Zhizhi Wang
    • , Christopher N. Merrikh
    • , Kevin S. Lang
    • , Peilong Lu
    • , Xin Li
    • , Houra Merrikh
    • , Zihe Rao
    •  & Wenqing Xu

  • Letter |

    Low soil moisture may reduce, or even reverse, the potential benefits of climate warming on photosynthesis in mesic, seasonally cold environments, both during drought and in regularly occurring, modestly dry periods during the growing season.

    • Peter B. Reich
    • , Kerrie M. Sendall
    • , Artur Stefanski
    • , Roy L. Rich
    • , Sarah E. Hobbie
    •  & Rebecca A. Montgomery

  • Letter |

    An organic copolymer with compositionally tailored tacticity exhibits behaviour reminiscent of a morphotropic phase boundary, with an intramolecular order-to-disorder transition in the crystalline phase and a very large piezoelectric coefficient.

    • Yang Liu
    • , Haibibu Aziguli
    • , Bing Zhang
    • , Wenhan Xu
    • , Wenchang Lu
    • , J. Bernholc
    •  & Qing Wang

  • Letter |

    The structure of a pilus assembly intermediate reveals the timing of subunit polymerization and how chaperone–subunit complexes are transferred from N-terminal to C-terminal domains of the usher in the formation of bacterial pili.

    • Minge Du
    • , Zuanning Yuan
    • , Hongjun Yu
    • , Nadine Henderson
    • , Samema Sarowar
    • , Gongpu Zhao
    • , Glenn T. Werneburg
    • , David G. Thanassi
    •  & Huilin Li

  • Letter |

    Cultures grown from small aggregates of mouse embryonic stem cells can be induced to organize spatial and temporal patterns of gene expression that parallel those of the early embryo, offering a potentially useful system for studying early development.

    • Leonardo Beccari
    • , Naomi Moris
    • , Mehmet Girgin
    • , David A. Turner
    • , Peter Baillie-Johnson
    • , Anne-Catherine Cossy
    • , Matthias P. Lutolf
    • , Denis Duboule
    •  & Alfonso Martinez Arias
More Latest Research More Latest Research

Latest Reviews & Analysis

  • News & Views |

    Asgard archaea are the closest known relatives of nucleus-bearing organisms called eukaryotes. A study indicates that these archaea have a dynamic network of actin protein — a trait thought of as eukaryote-specific.

    • Laura Eme
    •  & Thijs J. G. Ettema

  • News & Views |

    The bacterial-defence system CRISPR–Cas can store DNA snippets that correspond to encountered viral RNA sequences. One such system has now been harnessed to record gene expression over time in bacteria.

    • Chase L. Beisel

  • News & Views |

    An organic polymer exhibits a phase transition that is associated with improved electromechanical properties. This feature links organic polymers with widely used perovskite materials, and could have many applications.

    • Ronald E. Cohen

  • News & Views |

    Antiviral drugs prevent HIV from replicating, but the virus can hide in the cells of infected individuals in a non-replicating, latent form. A two-pronged approach to target this latent virus shows promise in monkeys.

    • Sharon R. Lewin

  • News & Views |

    In developing embryos, molecular and physical differences divide the cells that will form eggs or sperm and those that will form the body. The mouse protein OTX2 directs this decision by blocking reproductive-cell fate.

    • Diana J. Laird

  • News & Views |

    What Nature was saying 50 and 100 years ago.

More Reviews & Analysis More Reviews & Analysis

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Nature Outlook

Brain cancer

Daria Kirpach

Brain cancer

Brain cancer is one of the most aggressive and difficult-to-treat malignancies. Moreover, in the almost 50 years since the start of the war on cancer, the prospects for people who develop brain cancer have improved much more slowly than those of individuals with other types of cancer.
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