How cells’ ‘lava lamp’ effect could make cancer drugs more powerful

Discovery that synthetic compounds form concentrated droplets inside cells could shake up drug development — including the hunt for coronavirus treatments.

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  • An imaging method combining soft-landing electrospray ion beam deposition and low-temperature scanning tunnelling microscopy resolves the structures of glycans at sub-nanometre resolution, revealing the connectivity of glycan chains and the types of linkages.

    • X. Wu
    • M. Delbianco
    • K. Kern
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  • A cryo-electron microscopy structure of the β1-adrenoceptor coupled to β-arrestin 1 and activated by the biased agonist formoterol, as well as the crystal structure of a related formoterol-bound adrenoreceptor, provide insights into biased signalling in these systems.

    • Yang Lee
    • Tony Warne
    • Christopher G. Tate
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  • A turnkey regime for soliton microcombs is demonstrated, in which solitons are generated by switching on a co-integrated pump laser, eliminating the need for photonic and electronic control circuitry.

    • Boqiang Shen
    • Lin Chang
    • John E. Bowers
    Article
  • Skeletal remains from the Neolithic passage tomb at Newgrange (Ireland) represent the adult son of a first-degree incestuous union, suggesting that a politico-religious elite may have controlled the construction of Irish sites of this type.

    • Lara M. Cassidy
    • Ros Ó Maoldúin
    • Daniel G. Bradley
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2020 South Korea

2020 South Korea

A concerted government push to make South Korea an innovation leader, backed by strong investment and systemic reform, has brought rapid and long-lasting results.
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