Nature

Did pangolins spread the China coronavirus to people?

Genetic sequences of viruses isolated from the scaly animals are 99% similar to that of the circulating virus — but the work is yet to be formally published.

‘Avalanche’ of spider-paper retractions shakes behavioural-ecology community

Allegations of fabricated data have prompted a university investigation and some soul-searching.
Giuliana Viglione

News 07 Feb 2020
3D printing gets bigger, faster and stronger

Research advances are changing the image of a once-niche technology.
Mark Zastrow

News Feature 05 Feb 2020
Global genomics project unravels cancer’s complexity at unprecedented scale

A massive international effort has yielded multifaceted studies of more than 2,600 tumours from 38 tissues, generating a wealth of insights into the genetic basis of cancer.
Marcin Cieslik
Arul M. Chinnaiyan

News & Views 05 Feb 2020
Daily briefing: Scientist banned from journal for citation abuse

One of the world’s most highly cited researchers has been barred from two journals. Plus, T-shirt weather in Antarctica breaks temperature records and three ambitious projects that aim to directly detect dark matter.
Flora Graham

Nature Briefing 07 Feb 2020
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Current Issue 06 Feb 2020

News & Comment

Coronavirus latest: global infections surge past 30,000

Updates on the respiratory illness that has infected tens of thousands of people.

News 07 Feb 2020
Did pangolins spread the China coronavirus to people?
David Cyranoski

News 07 Feb 2020
‘Avalanche’ of spider-paper retractions shakes behavioural-ecology community
Giuliana Viglione

News 07 Feb 2020
Combat burnout: respect the out-of-office message

Editorial 07 Feb 2020
Highly cited researcher banned from journal board for citation abuse
Richard Van Noorden

News 06 Feb 2020
The era of massive cancer sequencing projects has reached a turning point

Editorial 05 Feb 2020
Genomics: data sharing needs an international code of conduct
Mark Phillips
Fruzsina Molnár-Gábor
Bartha M. Knoppers

Comment 05 Feb 2020

Latest Reviews & Analysis

- Global genomics project unravels cancer’s complexity at unprecedented scale
  
  A massive international effort has yielded multifaceted studies of more than 2,600 tumours from 38 tissues, generating a wealth of insights into the genetic basis of cancer.
  
  Marcin Cieslik
  Arul M. Chinnaiyan
  
  News & Views 05 Feb 2020
- Neurodegenerative diseases distinguished through protein-structure analysis
  
  Parkinson’s disease and multiple system atrophy involve the protein α-synuclein. Proof that aggregated α-synuclein adopts a different structure in each case suggests that its conformation underlies the distinct disorders.
  
  Juan Atilio Gerez
  Roland Riek
  
  News & Views 05 Feb 2020
- Molecular architecture of the key precursor of thyroid hormones revealed
  
  The structure of thyroglobulin, the enormous protein that acts as a precursor for thyroid hormones, has been determined, and its hormone-forming tyrosine amino-acid residues have been identified.
  
  Nancy Carrasco
  
  News & Views 05 Feb 2020
- How to silence an X chromosome
  
  The non-coding RNA Xist has been shown to enlist the SPEN protein to recruit a team of protein complexes — initiating the process that prevents transcription of one of the two X chromosomes found in female mammalian cells.
  
  Jackson B. Trotman
  J. Mauro Calabrese
  
  News & Views 05 Feb 2020
- Muon colliders come a step closer
  
  Particle colliders that use elementary particles called muons could outperform conventional colliders, while requiring much smaller facilities. Muon cooling, a milestone on the road to these muon colliders, has now been achieved.
  
  Robert D. Ryne
  
  News & Views 05 Feb 2020
- A platform for making and transferring oxide films
  
  Atsushi Tsukazaki
  
  News & Views 05 Feb 2020
- From the archive
  
  News & Views 04 Feb 2020
- Early climate models successfully predicted global warming
  
  Jennifer E. Kay
  
  News & Views 03 Feb 2020
- Protein structure reveals how a malaria parasite imports a wide range of sugars
  
  Thorsten Althoff
  Jeff Abramson
  
  News & Views 29 Jan 2020
- Smoke signals in the DNA of normal lung cells
  
  Gerd P. Pfeifer
  
  News & Views 29 Jan 2020

Latest Research

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
Marcin J. Suskiewicz
Florian Zobel
Ivan Ahel

Article 06 Feb 2020
The evolutionary history of 2,658 cancers

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.
Moritz Gerstung
Clemency Jolly
Peter Van Loo

Article 06 Feb 2020
The repertoire of mutational signatures in human cancer

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.
Ludmil B. Alexandrov
Jaegil Kim
Michael R. Stratton

Article 05 Feb 2020
Live-animal imaging of native haematopoietic stem and progenitor cells

A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.
Constantina Christodoulou
Joel A. Spencer
Fernando D. Camargo

Article 05 Feb 2020
Quantum crystal structure in the 250-kelvin superconducting lanthanum hydride

Quantum atomic fluctuations have a crucial role in stabilizing the crystal structure of the high-pressure superconducting phase of lanthanum hydride.
Ion Errea
Francesco Belli
José A. Flores-Livas

Article 05 Feb 2020

Researchers are homing in on the myriad ways in which the bacteria and other microorganisms that inhabit the human digestive system affect our health – and how they could point the way towards new therapies.

Nature Outlook 29 Jan 2020