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Volume 564 Issue 7736

Latest Research

  • Article |

    The mouse develops a developmentally and functionally distinct, non-canonical beige fat cell type as an adaptation to cold ambient temperature.

    • Yong Chen
    • , Kenji Ikeda
    • , Takeshi Yoneshiro
    • , Annarita Scaramozza
    • , Kazuki Tajima
    • , Qiang Wang
    • , Kyeongkyu Kim
    • , Kosaku Shinoda
    • , Carlos Henrique Sponton
    • , Zachary Brown
    • , Andrew Brack
    •  & Shingo Kajimura

  • Letter |

    Analyses of over 700,000 satellite images to map the global extent of tidal flats over the past thirty years, and enable assessments of the status and likely future trajectories of these coastal ecosystems.

    • Nicholas J. Murray
    • , Stuart R. Phinn
    • , Michael DeWitt
    • , Renata Ferrari
    • , Renee Johnston
    • , Mitchell B. Lyons
    • , Nicholas Clinton
    • , David Thau
    •  & Richard A. Fuller

  • Letter |

    Neoantigen-targeting vaccines are a feasible therapy for tumours with a low mutation burden and immunologically ‘cold’ tumour microenvironment, as neoantigen-specific T cells from the peripheral blood migrate into intracranial glioblastoma, thereby altering the immune milieu of the glioblastoma.

    • Derin B. Keskin
    • , Annabelle J. Anandappa
    • , Jing Sun
    • , Itay Tirosh
    • , Nathan D. Mathewson
    • , Shuqiang Li
    • , Giacomo Oliveira
    • , Anita Giobbie-Hurder
    • , Kristen Felt
    • , Evisa Gjini
    • , Sachet A. Shukla
    • , Zhuting Hu
    • , Letitia Li
    • , Phuong M. Le
    • , Rosa L. Allesøe
    • , Alyssa R. Richman
    • , Monika S. Kowalczyk
    • , Sara Abdelrahman
    • , Jack E. Geduldig
    • , Sarah Charbonneau
    • , Kristine Pelton
    • , J. Bryan Iorgulescu
    • , Liudmila Elagina
    • , Wandi Zhang
    • , Oriol Olive
    • , Christine McCluskey
    • , Lars R. Olsen
    • , Jonathan Stevens
    • , William J. Lane
    • , Andres M. Salazar
    • , Heather Daley
    • , Patrick Y. Wen
    • , E. Antonio Chiocca
    • , Maegan Harden
    • , Niall J. Lennon
    • , Stacey Gabriel
    • , Gad Getz
    • , Eric S. Lander
    • , Aviv Regev
    • , Jerome Ritz
    • , Donna Neuberg
    • , Scott J. Rodig
    • , Keith L. Ligon
    • , Mario L. Suvà
    • , Kai W. Wucherpfennig
    • , Nir Hacohen
    • , Edward F. Fritsch
    • , Kenneth J. Livak
    • , Patrick A. Ott
    • , Catherine J. Wu
    •  & David A. Reardon

  • Letter |

    Computational design incorporating modular buried hydrogen networks produces highly orthogonal protein heterodimers.

    • Zibo Chen
    • , Scott E. Boyken
    • , Mengxuan Jia
    • , Florian Busch
    • , David Flores-Solis
    • , Matthew J. Bick
    • , Peilong Lu
    • , Zachary L. VanAernum
    • , Aniruddha Sahasrabuddhe
    • , Robert A. Langan
    • , Sherry Bermeo
    • , T. J. Brunette
    • , Vikram Khipple Mulligan
    • , Lauren P. Carter
    • , Frank DiMaio
    • , Nikolaos G. Sgourakis
    • , Vicki H. Wysocki
    •  & David Baker

  • Letter |

    Phenotypically, transcriptionally and metabolically diverse subsets of TH17 cells develop in a chronic autoimmune disease: one subset has inferred stemness features and low anabolic metabolism, while a reciprocal subset has higher metabolic activity that supports transdifferentiation into TH1 cells.

    • Peer W. F. Karmaus
    • , Xiang Chen
    • , Seon Ah Lim
    • , Andrés A. Herrada
    • , Thanh-Long M. Nguyen
    • , Beisi Xu
    • , Yogesh Dhungana
    • , Sherri Rankin
    • , Wenan Chen
    • , Celeste Rosencrance
    • , Kai Yang
    • , Yiping Fan
    • , Yong Cheng
    • , John Easton
    • , Geoffrey Neale
    • , Peter Vogel
    •  & Hongbo Chi

  • Article |

    In mice, synaptic potentiation of transmission from the orbitofrontal cortex to the dorsal striatum drives compulsive reinforcement, a defining symptom of addiction.

    • Vincent Pascoli
    • , Agnès Hiver
    • , Ruud Van Zessen
    • , Michaël Loureiro
    • , Ridouane Achargui
    • , Masaya Harada
    • , Jérôme Flakowski
    •  & Christian Lüscher
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Latest Reviews & Analysis

  • News & Views |

    Observations reveal that a particular planetary nebula — the ejected envelope of an old star — is unusually enriched in rare carbon, nitrogen and oxygen isotopes. The finding could help to explain the origins of these isotopes.

    • Amanda Karakas

  • News & Views |

    Some fat cells convert energy into heat, so targeting them to induce weight loss is appealing. The discovery that a subset of the cells burns glucose, rather than both glucose and lipids, could improve our ability to do just that.

    • Wenfei Sun
    •  & Christian Wolfrum

  • News & Views |

    Almost half a century ago, it was predicted that the confinement of quantum fluctuations could induce mechanical rotation — the Casimir torque. This prediction has now been confirmed using liquid crystals.

    • Slobodan Žumer

  • News & Views |

    A study in mice identifies a brain adaptation that underlies the compulsive behaviour associated with drug addiction, and which might explain why some drug users behave compulsively whereas others do not.

    • Patricia Janak

  • News & Views |

    Clinical trials reveal that personalized vaccines can boost immune-cell responses to brain tumours that don’t usually respond to immunotherapy. The findings also point to how to improve such treatments.

    • Neeha Zaidi
    •  & Elizabeth M. Jaffee

  • News & Views |

    How Nature reported a strange apparition in 1918, and the latest Christmas toys in 1968.

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News & Comment

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Journal tools

Nature Outline

Liver cirrhosis

Andrew Khosravani

Liver cirrhosis

Long considered to be permanent, the extensive scarring found in livers with cirrhosis is now thought to be reversible.
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