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  • Letter | | open

    An analysis of more than 10,000 metagenomes from the TEDDY study provides a detailed functional profile of the gut microbiome in relation to islet autoimmunity, and supports the protective effects of short-chain fatty acids in early-onset type 1 diabetes.

    • Tommi Vatanen
    • , Eric A. Franzosa
    • , Randall Schwager
    • , Surya Tripathi
    • , Timothy D. Arthur
    • , Kendra Vehik
    • , Åke Lernmark
    • , William A. Hagopian
    • , Marian J. Rewers
    • , Jin-Xiong She
    • , Jorma Toppari
    • , Anette-G. Ziegler
    • , Beena Akolkar
    • , Jeffrey P. Krischer
    • , Christopher J. Stewart
    • , Nadim J. Ajami
    • , Joseph F. Petrosino
    • , Dirk Gevers
    • , Harri Lähdesmäki
    • , Hera Vlamakis
    • , Curtis Huttenhower
    •  & Ramnik J. Xavier

  • News & Views |

    An experiment has measured the energy spectrum of solar neutrinos associated with 99% of the nuclear reactions that power the Sun. The results provide a glimpse into the depths of the solar core.

    • Aldo Serenelli

  • Career Feature |

    Nature’s survey offers a snapshot of salaries and career paths in the scientific sector.

    • Chris Woolston

Current Issue |

Volume 562 Issue 7728

Latest Research

  • Letter | | open

    An analysis of more than 10,000 metagenomes from the TEDDY study provides a detailed functional profile of the gut microbiome in relation to islet autoimmunity, and supports the protective effects of short-chain fatty acids in early-onset type 1 diabetes.

    • Tommi Vatanen
    • , Eric A. Franzosa
    • , Randall Schwager
    • , Surya Tripathi
    • , Timothy D. Arthur
    • , Kendra Vehik
    • , Åke Lernmark
    • , William A. Hagopian
    • , Marian J. Rewers
    • , Jin-Xiong She
    • , Jorma Toppari
    • , Anette-G. Ziegler
    • , Beena Akolkar
    • , Jeffrey P. Krischer
    • , Christopher J. Stewart
    • , Nadim J. Ajami
    • , Joseph F. Petrosino
    • , Dirk Gevers
    • , Harri Lähdesmäki
    • , Hera Vlamakis
    • , Curtis Huttenhower
    •  & Ramnik J. Xavier

  • Article |

    Comparison of transcriptomic data from immune-stimulated cells across different species sheds light on the architecture of the innate immune response.

    • Tzachi Hagai
    • , Xi Chen
    • , Ricardo J. Miragaia
    • , Raghd Rostom
    • , Tomás Gomes
    • , Natalia Kunowska
    • , Johan Henriksson
    • , Jong-Eun Park
    • , Valentina Proserpio
    • , Giacomo Donati
    • , Lara Bossini-Castillo
    • , Felipe A. Vieira Braga
    • , Guy Naamati
    • , James Fletcher
    • , Emily Stephenson
    • , Peter Vegh
    • , Gosia Trynka
    • , Ivanela Kondova
    • , Mike Dennis
    • , Muzlifah Haniffa
    • , Armita Nourmohammad
    • , Michael Lässig
    •  & Sarah A. Teichmann

  • Article |

    Genetic or pharmacological inhibition of α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase increases NAD+ and improves mitochondrial function in nematodes and mice, and may have therapeutic potential in kidney and liver disease.

    • Elena Katsyuba
    • , Adrienne Mottis
    • , Marika Zietak
    • , Francesca De Franco
    • , Vera van der Velpen
    • , Karim Gariani
    • , Dongryeol Ryu
    • , Lucia Cialabrini
    • , Olli Matilainen
    • , Paride Liscio
    • , Nicola Giacchè
    • , Nadine Stokar-Regenscheit
    • , David Legouis
    • , Sophie de Seigneux
    • , Julijana Ivanisevic
    • , Nadia Raffaelli
    • , Kristina Schoonjans
    • , Roberto Pellicciari
    •  & Johan Auwerx

  • Letter |

    DNA damage induces translocation of cyclic GMP–AMP synthase to the nucleus, where it suppresses homologous recombination by interfering with the formation of the PARP1–Timeless complex.

    • Haipeng Liu
    • , Haiping Zhang
    • , Xiangyang Wu
    • , Dapeng Ma
    • , Juehui Wu
    • , Lin Wang
    • , Yan Jiang
    • , Yiyan Fei
    • , Chenggang Zhu
    • , Rong Tan
    • , Peter Jungblut
    • , Gang Pei
    • , Anca Dorhoi
    • , Qiaoling Yan
    • , Fan Zhang
    • , Ruijuan Zheng
    • , Siyu Liu
    • , Haijiao Liang
    • , Zhonghua Liu
    • , Hua Yang
    • , Jianxia Chen
    • , Peng Wang
    • , Tianqi Tang
    • , Wenxia Peng
    • , Zhangsen Hu
    • , Zhu Xu
    • , Xiaochen Huang
    • , Jie Wang
    • , Haohao Li
    • , Yilong Zhou
    • , Feng Liu
    • , Dapeng Yan
    • , Stefan H. E. Kaufmann
    • , Chang Chen
    • , Zhiyong Mao
    •  & Baoxue Ge

  • Letter |

    Analysis of deep-sea coral boron isotope data, as a proxy for pH and thus CO2 chemistry, provides evidence of CO2 storage in the deep Southern Ocean during the last ice age, and its rapid release on millennial to centennial timescales during deglaciation.

    • J. W. B. Rae
    • , A. Burke
    • , L. F. Robinson
    • , J. F. Adkins
    • , T. Chen
    • , C. Cole
    • , R. Greenop
    • , T. Li
    • , E. F. M. Littley
    • , D. C. Nita
    • , J. A. Stewart
    •  & B. J. Taylor

  • Letter |

    Wildebeest, particularly during their long migrations under hot arid conditions, gain a considerable increase in range as a result of having highly efficient muscles.

    • Nancy A. Curtin
    • , Hattie L. A. Bartlam-Brooks
    • , Tatjana Y. Hubel
    • , John C. Lowe
    • , Anthony R. Gardner-Medwin
    • , Emily Bennitt
    • , Stephen J. Amos
    • , Maja Lorenc
    • , Timothy G. West
    •  & Alan M. Wilson

  • Article |

    Reversion of adult skeletal stem cells to a developmental state underlies the growth of new bone during jaw regeneration, in a process that relies on mechanotransduction via the focal adhesion kinase protein.

    • Ryan C. Ransom
    • , Ava C. Carter
    • , Ankit Salhotra
    • , Tripp Leavitt
    • , Owen Marecic
    • , Matthew P. Murphy
    • , Michael L. Lopez
    • , Yuning Wei
    • , Clement D. Marshall
    • , Ethan Z. Shen
    • , Ruth Ellen Jones
    • , Amnon Sharir
    • , Ophir D. Klein
    • , Charles K. F. Chan
    • , Derrick C. Wan
    • , Howard Y. Chang
    •  & Michael T. Longaker

  • Article |

    Catastrophic rock weakening upon impact of a meteorite, and hence flow, is shown to be followed by regained rock strength that enabled the formation of the peak ring during cratering.

    • Ulrich Riller
    • , Michael H. Poelchau
    • , Auriol S. P. Rae
    • , Felix M. Schulte
    • , Gareth S. Collins
    • , H. Jay Melosh
    • , Richard A. F. Grieve
    • , Joanna V. Morgan
    • , Sean P. S. Gulick
    • , Johanna Lofi
    • , Abdoulaye Diaw
    • , Naoma McCall
    • , David A. Kring
    • , Joanna V. Morgan
    • , Sean P. S. Gulick
    • , Sophie L. Green
    • , Johanna Lofi
    • , Elise Chenot
    • , Gail L. Christeson
    • , Philippe Claeys
    • , Charles S. Cockell
    • , Marco J. L. Coolen
    • , Ludovic Ferrière
    • , Catalina Gebhardt
    • , Kazuhisa Goto
    • , Heather Jones
    • , David A. Kring
    • , Long Xiao
    • , Christopher M. Lowery
    • , Rubén Ocampo-Torres
    • , Ligia Perez-Cruz
    • , Annemarie E. Pickersgill
    • , Michael H. Poelchau
    • , Auriol S. P. Rae
    • , Cornelia Rasmussen
    • , Mario Rebolledo-Vieyra
    • , Ulrich Riller
    • , Honami Sato
    • , Jan Smit
    • , Sonia M. Tikoo-Schantz
    • , Naotaka Tomioka
    • , Michael T. Whalen
    • , Axel Wittmann
    • , Kosei Yamaguchi
    • , Jaime Urrutia Fucugauchi
    •  & Timothy J. Bralower

  • Letter |

    Female Drosophila that lack a microbiota are hyperactive, and xylose isomerase from Lactobacillus brevis is sufficient to reverse this effect.

    • Catherine E. Schretter
    • , Jost Vielmetter
    • , Imre Bartos
    • , Zsuzsa Marka
    • , Szabolcs Marka
    • , Sulabha Argade
    •  & Sarkis K. Mazmanian
More Latest Research More Latest Research

Latest Reviews & Analysis

  • News & Views |

    A gut bacterium has been found to modulate locomotor activity in the fruit fly Drosophila melanogaster. This effect is mediated by the level of a sugar and the activity of neurons that produce the molecule octopamine.

    • Angela E. Douglas

  • News & Views |

    An experiment has measured the energy spectrum of solar neutrinos associated with 99% of the nuclear reactions that power the Sun. The results provide a glimpse into the depths of the solar core.

    • Aldo Serenelli

  • News & Views |

    A natural material has been discovered that exhibits an extreme optical property known as in-plane hyperbolicity. The finding could lead to infrared optical components that are much smaller than those now available.

    • Thomas G. Folland
    •  & Joshua D. Caldwell

  • News & Views |

    What Nature was saying 50 and 100 years ago.

  • News & Views |

    A study has demonstrated the value of using autonomous drones for conservation purposes.

    • Mary Abraham
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Taj Francis

Science without borders

If the goal of science is to improve people’s lives, it is to the world’s poorer nations that researchers should look.
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