Diseases of the nervous system

Definition

Diseases of the nervous system refer to disorders that affect any part of the central nervous system (brain, spinal cord or cranial nerves) or peripheral nervous system.

Featured

Latest Research and Reviews

  • Research |

    In rodent models of Alzheimer's disease (AD) and epilepsy, seizure-dependent induction of ΔFosB results in epigenetic silencing of calbindin. Hippocampal inhibition of ΔFosB or elevation of calbindin rescues spatial memory deficits in mouse models of AD.

    • Jason C You
    • , Kavitha Muralidharan
    • , Jin W Park
    • , Iraklis Petrof
    • , Mark S Pyfer
    • , Brian F Corbett
    • , John J LaFrancois
    • , Yi Zheng
    • , Xiaohong Zhang
    • , Carrie A Mohila
    • , Daniel Yoshor
    • , Robert A Rissman
    • , Eric J Nestler
    • , Helen E Scharfman
    •  & Jeannie Chin
  • Reviews |

    • Raffael Kalisch
    • , Dewleen G. Baker
    • , Ulrike Basten
    • , Marco P. Boks
    • , George A. Bonanno
    • , Eddie Brummelman
    • , Andrea Chmitorz
    • , Guillén Fernàndez
    • , Christian J. Fiebach
    • , Isaac Galatzer-Levy
    • , Elbert Geuze
    • , Sergiu Groppa
    • , Isabella Helmreich
    • , Talma Hendler
    • , Erno J. Hermans
    • , Tanja Jovanovic
    • , Thomas Kubiak
    • , Klaus Lieb
    • , Beat Lutz
    • , Marianne B. Müller
    • , Ryan J. Murray
    • , Caroline M. Nievergelt
    • , Andreas Reif
    • , Karin Roelofs
    • , Bart P. F. Rutten
    • , David Sander
    • , Anita Schick
    • , Oliver Tüscher
    • , Ilse Van Diest
    • , Anne-Laura van Harmelen
    • , Ilya M. Veer
    • , Eric Vermetten
    • , Christiaan H. Vinkers
    • , Tor D. Wager
    • , Henrik Walter
    • , Michèle Wessa
    • , Michael Wibral
    •  & Birgit Kleim
  • Research | | open

    Induction of the cis form of phosphorylated tau (cis P-tau) has previously been shown to occur in animal models of traumatic brain injury (TBI), and blocking this form of tau using antibody was beneficial in a rodent model of severe TBI. Here the authors show that cis P-tau induction is a feature of several different forms of TBI in humans, and that administration of cis P-tau targeting antibody to rodents reduces or delays pathological features of TBI.

    • Onder Albayram
    • , Asami Kondo
    • , Rebekah Mannix
    • , Colin Smith
    • , Cheng-Yu Tsai
    • , Chenyu Li
    • , Megan K. Herbert
    • , Jianhua Qiu
    • , Michael Monuteaux
    • , Jane Driver
    • , Sandra Yan
    • , William Gormley
    • , Ava M. Puccio
    • , David O. Okonkwo
    • , Brandon Lucke-Wold
    • , Julian Bailes
    • , William Meehan
    • , Mark Zeidel
    • , Kun Ping Lu
    •  & Xiao Zhen Zhou
  • Research | | open

    • S Kelly
    • , N Jahanshad
    • , A Zalesky
    • , P Kochunov
    • , I Agartz
    • , C Alloza
    • , O A Andreassen
    • , C Arango
    • , N Banaj
    • , S Bouix
    • , C A Bousman
    • , R M Brouwer
    • , J Bruggemann
    • , J Bustillo
    • , W Cahn
    • , V Calhoun
    • , D Cannon
    • , V Carr
    • , S Catts
    • , J Chen
    • , J-x Chen
    • , X Chen
    • , C Chiapponi
    • , Kl K Cho
    • , V Ciullo
    • , A S Corvin
    • , B Crespo-Facorro
    • , V Cropley
    • , P De Rossi
    • , C M Diaz-Caneja
    • , E W Dickie
    • , S Ehrlich
    • , F-m Fan
    • , J Faskowitz
    • , H Fatouros-Bergman
    • , L Flyckt
    • , J M Ford
    • , J-P Fouche
    • , M Fukunaga
    • , M Gill
    • , D C Glahn
    • , R Gollub
    • , E D Goudzwaard
    • , H Guo
    • , R E Gur
    • , R C Gur
    • , T P Gurholt
    • , R Hashimoto
    • , S N Hatton
    • , F A Henskens
    • , D P Hibar
    • , I B Hickie
    • , L E Hong
    • , J Horacek
    • , F M Howells
    • , H E Hulshoff Pol
    • , C L Hyde
    • , D Isaev
    • , A Jablensky
    • , P R Jansen
    • , J Janssen
    • , E G Jönsson
    • , L A Jung
    • , R S Kahn
    • , Z Kikinis
    • , K Liu
    • , P Klauser
    • , C Knöchel
    • , M Kubicki
    • , J Lagopoulos
    • , C Langen
    • , S Lawrie
    • , R K Lenroot
    • , K O Lim
    • , C Lopez-Jaramillo
    • , A Lyall
    • , V Magnotta
    • , R C W Mandl
    • , D H Mathalon
    • , R W McCarley
    • , S McCarthy-Jones
    • , C McDonald
    • , S McEwen
    • , A McIntosh
    • , T Melicher
    • , R I Mesholam-Gately
    • , P T Michie
    • , B Mowry
    • , B A Mueller
    • , D T Newell
    • , P O'Donnell
    • , V Oertel-Knöchel
    • , L Oestreich
    • , S A Paciga
    • , C Pantelis
    • , O Pasternak
    • , G Pearlson
    • , G R Pellicano
    • , A Pereira
    • , J Pineda Zapata
    • , F Piras
    • , S G Potkin
    • , A Preda
    • , P E Rasser
    • , D R Roalf
    • , R Roiz
    • , A Roos
    • , D Rotenberg
    • , T D Satterthwaite
    • , P Savadjiev
    • , U Schall
    • , R J Scott
    • , M L Seal
    • , L J Seidman
    • , C Shannon Weickert
    • , C D Whelan
    • , M E Shenton
    • , J S Kwon
    • , G Spalletta
    • , F Spaniel
    • , E Sprooten
    • , M Stäblein
    • , D J Stein
    • , S Sundram
    • , Y Tan
    • , S Tan
    • , S Tang
    • , H S Temmingh
    • , L T Westlye
    • , S Tønnesen
    • , D Tordesillas-Gutierrez
    • , N T Doan
    • , J Vaidya
    • , N E M van Haren
    • , C D Vargas
    • , D Vecchio
    • , D Velakoulis
    • , A Voineskos
    • , J Q Voyvodic
    • , Z Wang
    • , P Wan
    • , D Wei
    • , T W Weickert
    • , H Whalley
    • , T White
    • , T J Whitford
    • , J D Wojcik
    • , H Xiang
    • , Z Xie
    • , H Yamamori
    • , F Yang
    • , N Yao
    • , G Zhang
    • , J Zhao
    • , T G M van Erp
    • , J Turner
    • , P M Thompson
    •  & G Donohoe

News and Comment