Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer).
Obesity is a risk factor for the development of cardiovascular diseases. In their Review, Lavie and colleagues summarize the deleterious consequences of obesity in patients with cardiovascular disease, review the available data on the benefits of weight loss, and explain the 'obesity paradox' phenomenon in this setting.
Obesity now rivals smoking as one of the leading preventable causes of cancer. Obesity-associated neutrophilia is now shown to enhance breast cancer metastasis and to be reversible through dietary modification and weight loss.