Neuroimmunology

Definition

Neuroimmunology is a field that studies the interaction of the immune and nervous systems.

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Latest Research and Reviews

  • Research |

    Spinal cord injury causes life-threatening infections. The authors report that this is partially mediated by a maladaptive neuroendocrine reflex extending from the spinal cord to the adrenal glands, where it blocks catecholamines while producing immunosuppressive corticosteroids. The effect depends on the spinal injury level, and normalization of hormones production by the adrenals rescues mice from pneumonia.

    • Harald Prüss
    • , Andrea Tedeschi
    • , Aude Thiriot
    • , Lydia Lynch
    • , Scott M Loughhead
    • , Susanne Stutte
    • , Irina B Mazo
    • , Marcel A Kopp
    • , Benedikt Brommer
    • , Christian Blex
    • , Laura-Christin Geurtz
    • , Thomas Liebscher
    • , Andreas Niedeggen
    • , Ulrich Dirnagl
    • , Frank Bradke
    • , Magdalena S Volz
    • , Michael J DeVivo
    • , Yuying Chen
    • , Ulrich H von Andrian
    •  & Jan M Schwab
  • Research |

    Maternal immune activation (MIA)-mediated abnormal behavioural phenotypes require defined gut commensal bacteria for the induction of IL-17-producing T helper 17 cells.

    • Sangdoo Kim
    • , Hyunju Kim
    • , Yeong Shin Yim
    • , Soyoung Ha
    • , Koji Atarashi
    • , Tze Guan Tan
    • , Randy S. Longman
    • , Kenya Honda
    • , Dan R. Littman
    • , Gloria B. Choi
    •  & Jun R. Huh
  • Research |

    The authors define a specific cortical subregion of the somatosensory cortex as a critical region of dysfunction that is causal to the emergence of abnormal social and repetitive behaviours in mice exposed to maternal inflammation.

    • Yeong Shin Yim
    • , Ashley Park
    • , Janet Berrios
    • , Mathieu Lafourcade
    • , Leila M. Pascual
    • , Natalie Soares
    • , Joo Yeon Kim
    • , Sangdoo Kim
    • , Hyunju Kim
    • , Ari Waisman
    • , Dan R. Littman
    • , Ian R. Wickersham
    • , Mark T. Harnett
    • , Jun R. Huh
    •  & Gloria B. Choi
  • Research |

    Intestinal type 2 innate lymphoid cells express the neuropeptide receptor NMUR1, which makes them responsive to neuronal neuromedin U, thereby promoting a type 2 cytokine response and accelerated expulsion of the gastro-intestinal nematode Nippostrongylus brasiliensis.

    • Christoph S. N. Klose
    • , Tanel Mahlakõiv
    • , Jesper B. Moeller
    • , Lucille C. Rankin
    • , Anne-Laure Flamar
    • , Hiroki Kabata
    • , Laurel A. Monticelli
    • , Saya Moriyama
    • , Gregory Garbès Putzel
    • , Nikolai Rakhilin
    • , Xiling Shen
    • , Evi Kostenis
    • , Gabriele M. König
    • , Takashi Senda
    • , Dustin Carpenter
    • , Donna L. Farber
    •  & David Artis
    Nature 549, 282–286

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