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Spine regulation is the biological process by which the structure or function of a dendritic spine is modulated by factors such as neuronal excitation. The structure of dendritic spines is highly variable; however, a typical spine consists of a spine head that may be mushroom- or cup-shaped and a thinner neck region.
This study examines how different odor-learning tasks affect structural plasticity in the olfactory bulb. Sensory deprivation, simple and complex odor learning tasks differently modify the spine density and morphology, revealing tailored plasticity.
The role of serotonin in prefrontal cortex development remains unexplored. Here, authors show that serotonin regulates maturation and stabilization of prefrontal excitatory synapses.
SynapShot combines ddFPs with engineered synaptic adhesion molecules for real-time observation of the structural plasticity of synapses in cultured cells and animals.
The binding of psychedelics to the BDNF receptor TrkB boosts plasticity in cultured neurons and underlies the antidepressant-like effects of these compounds in mice.
