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Microglia are the macrophages of the CNS, with innate neuroimmune function, and play important roles in tissue homeostasis, CNS development and neurodegeneration. Here human microglial gene expression profiles were generated. Human and mouse microglia were highly similar, except for aging-regulated genes, indicating that microglial aging differs between humans and mice.
Microglia are highly heterogeneous and plastic. However, the dynamics of their turnover have been difficult to visualize. A new multicolor reporter system reveals a plastic but stable network of microglia during health and disease.