Neuro–vascular interactions articles from across Nature Portfolio

Here, the authors demonstrate that CXCL5 expression is increased in ankle joints of gouty arthritis model mice. CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and joint inflammation.

Presenting mechanisms that modulate cerebral vessel tone as interaction graphs to support research design, interpret study findings, and generate hypotheses on disease.

Noradrenergic and serotonergic signaling are involved in modulating sensory stimulation-induced astrocyte Ca²⁺ dynamics, and each signaling pathway alters functional hyperemia differently.

One of the long-term sequelae associated with SARS-CoV-2 infection is ‘brain fog’, which is shown in this study to be linked to systemic inflammation and leakiness of the blood–brain barrier.

During retinal development in the mouse, angiogenesis was unexpectedly found to depend on temporally restricted dopamine production by retinal ganglion cells, rather than by canonical retinal dopamine neurons.

A study by Holstein-Rønsbo, Gan et al. published in this issue of Nature Neuroscience adds another dimension to the ‘glymphatic’ story — the role of functional hyperemia facilitating perivascular flow of cerebrospinal fluid along pial arteries.

Age-related decline in brain health is associated with poor blood flow and limitations in energy supply, although the vascular mechanisms are poorly understood. We report an age-related decrease in responsivity of brain microvessels, accompanied by a decrease in vessel density and loss of vascular mural cell processes.

During cortical development, the generation of neurons from progenitors coincides with increasing vascularization and oxygen levels in the fetal brain and the transition from anaerobic to aerobic metabolism. Dong et al. identify lactate, a metabolite of anaerobic glycolysis, as a multifunctional regulator that coordinates synchrony of cortical neurogenesis and angiogenesis.