Ion channels in the nervous system

Definition

Ion channels in the nervous system refers to the study of ion channels – proteins allowing charged particles to cross membranes – found in neurons and glia, where they are involved in maintaining the electrochemical gradients that allow neurons to produce action potentials and neurons and glia to release and recycle neurotransmitters.

Latest Research and Reviews

News and Comment

  • News and Views |

    The checkpoint pathway consisting of programmed death ligand 1 (PD-L1) and its receptor, PD-1, modulates immune function in cancer and infection, but unexpectedly, it also silences pain signals in nerves.

    • Michael Hirth
    • , Jagadeesh Gandla
    •  & Rohini Kuner
    Nature Neuroscience 20, 897–899
  • Correspondence |

    • Panos Zanos
    • , Ruin Moaddel
    • , Patrick J. Morris
    • , Polymnia Georgiou
    • , Jonathan Fischell
    • , Greg I. Elmer
    • , Manickavasagom Alkondon
    • , Peixiong Yuan
    • , Heather J. Pribut
    • , Nagendra S. Singh
    • , Katina S. S. Dossou
    • , Yuhong Fang
    • , Xi-Ping Huang
    • , Cheryl L. Mayo
    • , Edson X. Albuquerque
    • , Scott M. Thompson
    • , Craig J. Thomas
    • , Carlos A. Zarate
    •  & Todd D. Gould
    Nature 546, E4–E5
  • News and Views |

    Previous experiments have suggested that many P2X family channels undergo a time-dependent process of pore dilation when activated by ATP. Li et al. now propose a different interpretation of the key experiments.

    • Bruce P Bean
    Nature Neuroscience 18, 1534–1535