Ion channels in the nervous system

Definition

Ion channels in the nervous system refers to the study of ion channels – proteins allowing charged particles to cross membranes – found in neurons and glia, where they are involved in maintaining the electrochemical gradients that allow neurons to produce action potentials and neurons and glia to release and recycle neurotransmitters.

Latest Research and Reviews

  • Research |

    This study characterizes the properties of disease-causing mutations that produce sporadic amino acid replacements in proteins of people with autism and developmental delay. The mutations tend to cluster and reoccur at specific regions important to protein function, highlighting for future follow-up 200 candidate genes, many involved in neuronal signaling.

    • Madeleine R Geisheker
    • , Gabriel Heymann
    • , Tianyun Wang
    • , Bradley P Coe
    • , Tychele N Turner
    • , Holly A F Stessman
    • , Kendra Hoekzema
    • , Malin Kvarnung
    • , Marie Shaw
    • , Kathryn Friend
    • , Jan Liebelt
    • , Christopher Barnett
    • , Elizabeth M Thompson
    • , Eric Haan
    • , Hui Guo
    • , Britt-Marie Anderlid
    • , Ann Nordgren
    • , Anna Lindstrand
    • , Geert Vandeweyer
    • , Antonino Alberti
    • , Emanuela Avola
    • , Mirella Vinci
    • , Stefania Giusto
    • , Tiziano Pramparo
    • , Karen Pierce
    • , Srinivasa Nalabolu
    • , Jacob J Michaelson
    • , Zdenek Sedlacek
    • , Gijs W E Santen
    • , Hilde Peeters
    • , Hakon Hakonarson
    • , Eric Courchesne
    • , Corrado Romano
    • , R Frank Kooy
    • , Raphael A Bernier
    • , Magnus Nordenskjöld
    • , Jozef Gecz
    • , Kun Xia
    • , Larry S Zweifel
    •  & Evan E Eichler
  • Research |

    The authors identify programmed cell death ligand-1 (PD-L1), an immunity suppressor produced by cancer cells, as a new pain inhibitor and a neuromodulator. They report that PD-L1 is produced by melanoma and normal neural tissues and that it inhibits acute and chronic pain. Via activation of PD-1, its receptor, PD-L1 decreases the excitability of nociceptive neurons in mouse and human dorsal root ganglia.

    • Gang Chen
    • , Yong Ho Kim
    • , Hui Li
    • , Hao Luo
    • , Da-Lu Liu
    • , Zhi-Jun Zhang
    • , Mark Lay
    • , Wonseok Chang
    • , Yu-Qiu Zhang
    •  & Ru-Rong Ji
  • Research | | open

    Current approaches to thermogenetic manipulation of neuronal activity lack sufficient spatiotemporal resolution. Here the authors show that neurons expressing snake TRPA1 channels are activated at high temporal resolution with IR light and this technique can be used to elicit behaviour in zebrafish larvae.

    • Yulia G. Ermakova
    • , Aleksandr A. Lanin
    • , Ilya V. Fedotov
    • , Matvey Roshchin
    • , Ilya V. Kelmanson
    • , Dmitry Kulik
    • , Yulia A. Bogdanova
    • , Arina G. Shokhina
    • , Dmitry S. Bilan
    • , Dmitry B. Staroverov
    • , Pavel M. Balaban
    • , Andrei B. Fedotov
    • , Dmitry A. Sidorov-Biryukov
    • , Evgeny S. Nikitin
    • , Aleksei M. Zheltikov
    •  & Vsevolod V. Belousov
  • Research | | open

    N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR activity.

    • David P. Scanlon
    • , Alaji Bah
    • , Mickaël Krzeminski
    • , Wenbo Zhang
    • , Heather L. Leduc-Pessah
    • , Yi Na Dong
    • , Julie D. Forman-Kay
    •  & Michael W. Salter

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