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The peripheral nervous system is the part of the nervous system outside the brain and spinal cord. It consists of nerves that carry information between the central nervous system and the extremities of the body.
Hematopoietic sites in the Drosophila larva require the local peripheral nervous system for blood cells (hemocytes) to survive and proliferate, but how this is mediated is unclear. Here, the authors identify Activin-β from sensory neurons as signalling to hemocytes, affecting proliferation and adhesion.
A Cre-dependent capsid selection method, CREATE, was used to produce adeno-associated viral vectors that allow gene delivery to the entire central and peripheral nervous systems, with multicolor labeling of single cells.