Genetics

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.

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Latest Research and Reviews

  • Research
    | Open Access

    The exact molecular mechanisms driving FUS-mediated toxicity remain unclear. Here, the authors demonstrate that muscleblind (Mbl) is a novel modifier of FUS-associated ALS, with knockdown of endogenous Mbl suppressing neuromuscular junction defects and motor dysfunctions associated with FUS expression in Drosophila, as well as restoring reduced SMN protein levels in mammalian neuronal and human iPSC-derived motor neurons.

    • Ian Casci
    • , Karthik Krishnamurthy
    • , Sukhleen Kour
    • , Vadreenath Tripathy
    • , Nandini Ramesh
    • , Eric N. Anderson
    • , Lara Marrone
    • , Rogan A. Grant
    • , Stacie Oliver
    • , Lauren Gochenaur
    • , Krishani Patel
    • , Jared Sterneckert
    • , Amanda M. Gleixner
    • , Christopher J. Donnelly
    • , Marc-David Ruepp
    • , Antonella M. Sini
    • , Emanuela Zuccaro
    • , Maria Pennuto
    • , Piera Pasinelli
    •  & Udai Bhan Pandey
  • Research
    | Open Access

    • Jeremy R. deWaard
    • , Sujeevan Ratnasingham
    • , Evgeny V. Zakharov
    • , Alex V. Borisenko
    • , Dirk Steinke
    • , Angela C. Telfer
    • , Kate H. J. Perez
    • , Jayme E. Sones
    • , Monica R. Young
    • , Valerie Levesque-Beaudin
    • , Crystal N. Sobel
    • , Arusyak Abrahamyan
    • , Kyrylo Bessonov
    • , Gergin Blagoev
    • , Stephanie L. deWaard
    • , Chris Ho
    • , Natalia V. Ivanova
    • , Kara K. S. Layton
    • , Liuqiong Lu
    • , Ramya Manjunath
    • , Jaclyn T. A. McKeown
    • , Megan A. Milton
    • , Renee Miskie
    • , Norm Monkhouse
    • , Suresh Naik
    • , Nadya Nikolova
    • , Mikko Pentinsaari
    • , Sean W. J. Prosser
    • , Adriana E. Radulovici
    • , Claudia Steinke
    • , Connor P. Warne
    •  & Paul D. N. Hebert
  • Research
    | Open Access

    Class 1 CRISPR systems are not as developed for genome editing as Class 2 systems are. Here the authors show that Cas3 can be used to generate functional knockouts and knock-ins, as well as Cas3-mediated exon-skipping in DMD cells.

    • Hiroyuki Morisaka
    • , Kazuto Yoshimi
    • , Yuya Okuzaki
    • , Peter Gee
    • , Yayoi Kunihiro
    • , Ekasit Sonpho
    • , Huaigeng Xu
    • , Noriko Sasakawa
    • , Yuki Naito
    • , Shinichiro Nakada
    • , Takashi Yamamoto
    • , Shigetoshi Sano
    • , Akitsu Hotta
    • , Junji Takeda
    •  & Tomoji Mashimo
  • Research
    | Open Access

    Relapse, reinfection and recrudescence can all cause recurrent infection after treatment of Plasmodium vivax malaria in endemic areas, but are difficult to distinguish. Here the authors show that they can be differentiated probabilistically and thereby demonstrate the high efficacy of primaquine treatment in preventing relapse.

    • Aimee R. Taylor
    • , James A. Watson
    • , Cindy S. Chu
    • , Kanokpich Puaprasert
    • , Jureeporn Duanguppama
    • , Nicholas P. J. Day
    • , Francois Nosten
    • , Daniel E. Neafsey
    • , Caroline O. Buckee
    • , Mallika Imwong
    •  & Nicholas J. White

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