Population genetics

Definition

Population genetics is the study of the genetic composition of populations, including distributions and changes in genotype and phenotype frequency in response to the processes of natural selection, genetic drift, mutation and gene flow.

Latest Research and Reviews

  • Research | | open

    It is known that males have lower recombination rates than females over much of the genome but little is known about differences at a fine scale. Here the authors combine data from over 100,000 meioses and show that the majority of differences can be explained by variation in hotspot magnitude.

    • Claude Bhérer
    • , Christopher L. Campbell
    •  & Adam Auton
  • Research | | open

    Fei Lu, Punna Ramu and colleagues construct a cassava haplotype map (HapMapII) by using deep-sequencing data from 241 accessions and identify over 28 million segregating variants. They find that clonal propagation has led to fixation of deleterious mutations, which have been ineffectively purged, owing to limited recombination

    • Punna Ramu
    • , Williams Esuma
    • , Robert Kawuki
    • , Ismail Y Rabbi
    • , Chiedozie Egesi
    • , Jessen V Bredeson
    • , Rebecca S Bart
    • , Janu Verma
    • , Edward S Buckler
    •  & Fei Lu
  • Research |

    Patrick Ellinor and colleagues report meta-analyses of common and rare variant association studies for atrial fibrillation across multiple populations. They identify 12 new loci, some of which implicate genes in atrial electrical and mechanical function.

    • the AFGen Consortium
    • , Ingrid E Christophersen
    • , Michiel Rienstra
    • , Carolina Roselli
    • , Xiaoyan Yin
    • , Bastiaan Geelhoed
    • , John Barnard
    • , Honghuang Lin
    • , Dan E Arking
    • , Albert V Smith
    • , Christine M Albert
    • , Mark Chaffin
    • , Nathan R Tucker
    • , Molong Li
    • , Derek Klarin
    • , Nathan A Bihlmeyer
    • , Siew-Kee Low
    • , Peter E Weeke
    • , Martina Müller-Nurasyid
    • , J Gustav Smith
    • , Jennifer A Brody
    • , Maartje N Niemeijer
    • , Marcus Dörr
    • , Stella Trompet
    • , Jennifer Huffman
    • , Stefan Gustafsson
    • , Claudia Schurmann
    • , Marcus E Kleber
    • , Leo-Pekka Lyytikäinen
    • , Ilkka Seppälä
    • , Rainer Malik
    • , Andrea R V R Horimoto
    • , Marco Perez
    • , Juha Sinisalo
    • , Stefanie Aeschbacher
    • , Sébastien Thériault
    • , Jie Yao
    • , Farid Radmanesh
    • , Stefan Weiss
    • , Alexander Teumer
    • , Seung Hoan Choi
    • , Lu-Chen Weng
    • , Sebastian Clauss
    • , Rajat Deo
    • , Daniel J Rader
    • , Svati H Shah
    • , Albert Sun
    • , Jemma C Hopewell
    • , Stephanie Debette
    • , Ganesh Chauhan
    • , Qiong Yang
    • , Bradford B Worrall
    • , Guillaume Paré
    • , Yoichiro Kamatani
    • , Yanick P Hagemeijer
    • , Niek Verweij
    • , Joylene E Siland
    • , Michiaki Kubo
    • , Jonathan D Smith
    • , David R Van Wagoner
    • , Joshua C Bis
    • , Siegfried Perz
    • , Bruce M Psaty
    • , Paul M Ridker
    • , Jared W Magnani
    • , Tamara B Harris
    • , Lenore J Launer
    • , M Benjamin Shoemaker
    • , Sandosh Padmanabhan
    • , Jeffrey Haessler
    • , Traci M Bartz
    • , Melanie Waldenberger
    • , Peter Lichtner
    • , Marina Arendt
    • , Jose E Krieger
    • , Mika Kähönen
    • , Lorenz Risch
    • , Alfredo J Mansur
    • , Annette Peters
    • , Blair H Smith
    • , Lars Lind
    • , Stuart A Scott
    • , Yingchang Lu
    • , Erwin B Bottinger
    • , Jussi Hernesniemi
    • , Cecilia M Lindgren
    • , Jorge A Wong
    • , Jie Huang
    • , Markku Eskola
    • , Andrew P Morris
    • , Ian Ford
    • , Alex P Reiner
    • , Graciela Delgado
    • , Lin Y Chen
    • , Yii-Der Ida Chen
    • , Roopinder K Sandhu
    • , Man Li
    • , Eric Boerwinkle
    • , Lewin Eisele
    • , Lars Lannfelt
    • , Moritz F Sinner
    • , Erik Ingelsson
    • , Efthymia Vlachopoulou
    • , David Conen
    • , Nancy L Pedersen
    • , Lynne J Hocking
    • , Daniel I Chasman
    • , Martin Dichgans
    • , Jonathan Rosand
    • , David Porteous
    • , Pim van der Harst
    • , Stefanie Heilmann-Heimbach
    • , Vilmundur Gudnason
    • , Charles Kooperberg
    • , Uwe Völker
    • , Toshihiro Tanaka
    • , Mina K Chung
    • , Natalia Rost
    • , Kent D Taylor
    • , Marju Orho-Melander
    • , Dan M Roden
    • , Olle Melander
    • , Marja-Liisa Lokki
    • , Karl-Heinz Jöckel
    • , Emelia J Benjamin
    • , Henry J Lin
    • , Sekar Kathiresan
    • , Joshua C Denny
    • , Nona Sotoodehnia
    • , Jan Heeringa
    • , Patrick T Ellinor
    • , Christopher Newton-Cheh
    • , Christopher D Anderson
    • , Alvaro Alonso
    • , Xiuqing Guo
    • , Kjell Nikus
    • , Patrik K Magnusson
    • , Jerome I Rotter
    • , Oscar H Franco
    • , Kathryn L Lunetta
    • , Peter Almgren
    • , Archie Campbell
    • , Steven A Lubitz
    • , Stephan B Felix
    • , Anders Hamsten
    • , Stefan Kääb
    • , Elsayed Z Soliman
    • , Winfried März
    • , Andre G Uitterlinden
    • , Jari Laurikka
    • , Jennifer Kriebel
    • , Susan R Heckbert
    • , Christian Shaffer
    • , Dawood Darbar
    • , Ruth J F Loos
    • , Paul L Huang
    • , Bruno H Stricker
    • , Caroline Hayward
    • , Alexandre Pereira
    • , J Wouter Jukema
    • , Peter W Macfarlane
    • , Albert Hofman
    •  & Terho Lehtimäki
  • Research |

    Kaoru Ito, Yoichiro Kamatani, Toshihiro Tanaka and colleagues report a genome-wide association study for atrial fibrillation in the Japanese population. They identify six new loci, five of which are not associated with atrial fibrillation in individuals of European ancestry, suggesting that they may be specific to the Japanese population.

    • Siew-Kee Low
    • , Atsushi Takahashi
    • , Yusuke Ebana
    • , Kouichi Ozaki
    • , Ingrid E Christophersen
    • , Patrick T Ellinor
    • , AFGen Consortium
    • , Soichi Ogishima
    • , Masayuki Yamamoto
    • , Mamoru Satoh
    • , Makoto Sasaki
    • , Taiki Yamaji
    • , Motoki Iwasaki
    • , Shoichiro Tsugane
    • , Keitaro Tanaka
    • , Mariko Naito
    • , Kenji Wakai
    • , Hideo Tanaka
    • , Tetsushi Furukawa
    • , Michiaki Kubo
    • , Kaoru Ito
    • , Yoichiro Kamatani
    •  & Toshihiro Tanaka

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