Genomics

Definition

Genomics is the study of the full genetic complement of an organism (the genome). It employs recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyse the structure and function of genomes.

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News and Comment

  • News and Views |

    A high-quality barley genome reveals a surprising compartmentalization of genes and repetitive sequences in chromosomes. This advance paves the way for improved genetic optimization of cereals. See Article p.427

    • Beat Keller
    •  & Simon G. Krattinger
    Nature 544, 424–425
  • News and Views |

    Mammalian SWI/SNF complexes have critical roles in development and differentiation, and are implicated in the pathogenesis of several diseases; however, the mechanisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely understood. Newly identified loss-of-function mutations in the SMARCD2 gene (part of the SMARCD1, SMARCD2 and SMARCD3 paralog family) reveal an evolutionarily conserved role specifically for the SMARCD2 subunit in granulopoiesis, and further investigation implicates the CEBPɛ transcription factor as a key effector of this specific function.

    • Brittany C Michel
    •  & Cigall Kadoch
    Nature Genetics 49, 655–657
  • News and Views |

    A new resequencing analysis of weedy rice (Oryza sativa L.) biotypes illuminates distinct evolutionary paths and outcomes of de-domestication and ferality. This largest effort to date in weedy plant genomics gives a better understanding of weediness while also providing a promising source of alleles for rice breeding.

    • C Neal Stewart Jr
    Nature Genetics 49, 654–655