Sequencing

Definition

Sequencing refers to the techniques used to determine the primary structure of an unbranched biopolymer (DNA, RNA, protein, carbohydrate) resulting in a symbolic linear depiction of the monomeric subunits which summarizes much of the atomic-level structure of the molecule.

Latest Research and Reviews

  • Research | | open

    Human T-cell leukaemia virus type-1 and bovine leukaemia virus infect T and B lymphocytes and lead to aggressive leukaemia. Here, the authors show these proviruses integrate near cancer drivers perturbing transcription termination or antisense RNA-dependent interaction, suggesting post-transcriptional mechanisms in some cases.

    • Nicolas Rosewick
    • , Keith Durkin
    • , Maria Artesi
    • , Ambroise Marçais
    • , Vincent Hahaut
    • , Philip Griebel
    • , Natasa Arsic
    • , Véronique Avettand-Fenoel
    • , Arsène Burny
    • , Carole Charlier
    • , Olivier Hermine
    • , Michel Georges
    •  & Anne Van den Broeke
  • Research | | open

    Detection of de novo, low frequency mutations is important for characterising heterogeneous cell populations, such as those found in cancer cell populations. Here the authors present o2n-seq, an ultrasensitive method with highly efficient data usage for detection of rare mutations.

    • Kaile Wang
    • , Shujuan Lai
    • , Xiaoxu Yang
    • , Tianqi Zhu
    • , Xuemei Lu
    • , Chung-I Wu
    •  & Jue Ruan
  • Research | | open

    Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.

    • Coen M. Adema
    • , LaDeana W. Hillier
    • , Catherine S. Jones
    • , Eric S. Loker
    • , Matty Knight
    • , Patrick Minx
    • , Guilherme Oliveira
    • , Nithya Raghavan
    • , Andrew Shedlock
    • , Laurence Rodrigues do Amaral
    • , Halime D. Arican-Goktas
    • , Juliana G. Assis
    • , Elio Hideo Baba
    • , Olga L. Baron
    • , Christopher J. Bayne
    • , Utibe Bickham-Wright
    • , Kyle K. Biggar
    • , Michael Blouin
    • , Bryony C. Bonning
    • , Chris Botka
    • , Joanna M. Bridger
    • , Katherine M. Buckley
    • , Sarah K. Buddenborg
    • , Roberta Lima Caldeira
    • , Julia Carleton
    • , Omar S. Carvalho
    • , Maria G. Castillo
    • , Iain W. Chalmers
    • , Mikkel Christensens
    • , Sandra Clifton
    • , Celine Cosseau
    • , Christine Coustau
    • , Richard M. Cripps
    • , Yesid Cuesta-Astroz
    • , Scott F. Cummins
    • , Leon di Stephano
    • , Nathalie Dinguirard
    • , David Duval
    • , Scott Emrich
    • , Cédric Feschotte
    • , Rene Feyereisen
    • , Peter FitzGerald
    • , Catrina Fronick
    • , Lucinda Fulton
    • , Richard Galinier
    • , Sandra G. Gava
    • , Michael Geusz
    • , Kathrin K. Geyer
    • , Gloria I. Giraldo-Calderón
    • , Matheus de Souza Gomes
    • , Michelle A. Gordy
    • , Benjamin Gourbal
    • , Christoph Grunau
    • , Patrick C. Hanington
    • , Karl F. Hoffmann
    • , Daniel Hughes
    • , Judith Humphries
    • , Daniel J. Jackson
    • , Liana K. Jannotti-Passos
    • , Wander de Jesus Jeremias
    • , Susan Jobling
    • , Bishoy Kamel
    • , Aurélie Kapusta
    • , Satwant Kaur
    • , Joris M. Koene
    • , Andrea B. Kohn
    • , Dan Lawson
    • , Scott P Lawton
    • , Di Liang
    • , Yanin Limpanont
    • , Sijun Liu
    • , Anne E. Lockyer
    • , TyAnna L. Lovato
    • , Fernanda Ludolf
    • , Vince Magrini
    • , Donald P. McManus
    • , Monica Medina
    • , Milind Misra
    • , Guillaume Mitta
    • , Gerald M. Mkoji
    • , Michael J. Montague
    • , Cesar Montelongo
    • , Leonid L. Moroz
    • , Monica C. Munoz-Torres
    • , Umar Niazi
    • , Leslie R. Noble
    • , Francislon S. Oliveira
    • , Fabiano S. Pais
    • , Anthony T. Papenfuss
    • , Rob Peace
    • , Janeth J. Pena
    • , Emmanuel A. Pila
    • , Titouan Quelais
    • , Brian J. Raney
    • , Jonathan P. Rast
    • , David Rollinson
    • , Izinara C. Rosse
    • , Bronwyn Rotgans
    • , Edwin J. Routledge
    • , Kathryn M. Ryan
    • , Larissa L. S. Scholte
    • , Richard K. Wilson
    • , Kenneth B. Storey
    • , Si-Ming Zhang
    • , Min Zhao
    • , Chad Tomlinson
    • , Mohammed Yusuf
    • , Jacob A. Tennessen
    • , Anthony J. Walker
    • , Timothy P. Yoshino
    • , Emanuela V. Volpi
    • , Damian L. Trujillo
    • , Xiao-Jun Wu
    • , Martin Swain
    • , Tianfang Wang
    • , Ittiprasert Wannaporn
    •  & Wesley C. Warren

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