Behavioural genetics

Definition

Behavioural genetics is the interdisciplinary effort to establish causal links between genes and animal (including human) behavioural traits and neural mechanisms. Methods used include twin studies, quantitative trait mapping by linkage to allelic variants, transgenic animals and targeted gene disruption or silencing.

Latest Research and Reviews

  • Research | | open

    • Dong Li
    • , Xiao Chang
    • , John J. Connolly
    • , Lifeng Tian
    • , Yichuan Liu
    • , Elizabeth J. Bhoj
    • , Nora Robinson
    • , Debra Abrams
    • , Yun R. Li
    • , Jonathan P. Bradfield
    • , Cecilia E. Kim
    • , Jin Li
    • , Fengxiang Wang
    • , James Snyder
    • , Maria Lemma
    • , Cuiping Hou
    • , Zhi Wei
    • , Yiran Guo
    • , Haijun Qiu
    • , Frank D. Mentch
    • , Kelly A. Thomas
    • , Rosetta M. Chiavacci
    • , Roger Cone
    • , Bingshan Li
    • , Patrick A. Sleiman
    •  & Hakon Hakonarson
  • Research |

    Noxious thermal and mechanical stimuli have to be faithfully detected and avoided to ensure survival. In this study, the authors uncover a modality-specific circuit responsible specifically for mechanonociceptive behavior in Drosophila. They show that the escape response to mechanical but not thermal noxious stimuli requires multisensory integration by mechanosensory neurons and neuromodulatory feedback signaling.

    • Chun Hu
    • , Meike Petersen
    • , Nina Hoyer
    • , Bettina Spitzweck
    • , Federico Tenedini
    • , Denan Wang
    • , Alisa Gruschka
    • , Lara S Burchardt
    • , Emanuela Szpotowicz
    • , Michaela Schweizer
    • , Ananya R Guntur
    • , Chung-Hui Yang
    •  & Peter Soba
  • Research |

    Elise Robinson and colleagues present the polygenic transmission disequilibrium test (pTDT) for evaluating transmission of polygenic risk in family-based study designs. The authors apply pTDT to a cohort of autism spectrum disorder (ASD) families and find that common polygenic variation acts additively with de novo variants to contribute to ASD risk.

    • Daniel J Weiner
    • , Emilie M Wigdor
    • , Stephan Ripke
    • , Raymond K Walters
    • , Jack A Kosmicki
    • , Jakob Grove
    • , Kaitlin E Samocha
    • , Jacqueline I Goldstein
    • , Aysu Okbay
    • , Jonas Bybjerg-Grauholm
    • , Thomas Werge
    • , David M Hougaard
    • , Jacob Taylor
    • , iPSYCH-Broad Autism Group
    • , Marie Bækvad-Hansen
    • , Ashley Dumont
    • , Christine Hansen
    • , Thomas F Hansen
    • , Daniel Howrigan
    • , Manuel Mattheisen
    • , Jennifer Moran
    • , Ole Mors
    • , Merete Nordentoft
    • , Bent Nørgaard-Pedersen
    • , Timothy Poterba
    • , Jesper Poulsen
    • , Christine Stevens
    • , Psychiatric Genomics Consortium Autism Group
    • , Verneri Anttila
    • , Peter Holmans
    • , Hailiang Huang
    • , Lambertus Klei
    • , Phil H Lee
    • , Sarah E Medland
    • , Benjamin Neale
    • , Lauren A Weiss
    • , Lonnie Zwaigenbaum
    • , Timothy W Yu
    • , Kerstin Wittemeyer
    • , A Jeremy Willsey
    • , Ellen M Wijsman
    • , Thomas H Wassink
    • , Regina Waltes
    • , Christopher A Walsh
    • , Simon Wallace
    • , Jacob A S Vorstman
    • , Veronica J Vieland
    • , Astrid M Vicente
    • , Herman van Engeland
    • , Kathryn Tsang
    • , Ann P Thompson
    • , Peter Szatmari
    • , Oscar Svantesson
    • , Stacy Steinberg
    • , Kari Stefansson
    • , Hreinn Stefansson
    • , Matthew W State
    • , Latha Soorya
    • , Teimuraz Silagadze
    • , Stephen W Scherer
    • , Gerard D Schellenberg
    • , Sven Sandin
    • , Evald Saemundsen
    • , Guy A Rouleau
    • , Bernadette Rogé
    • , Kathryn Roeder
    • , Wendy Roberts
    • , Jennifer Reichert
    • , Abraham Reichenberg
    • , Karola Rehnström
    • , Regina Regan
    • , Fritz Poustka
    • , Christopher S Poultney
    • , Joseph Piven
    • , Dalila Pinto
    • , Margaret A Pericak-Vance
    • , Milica Pejovic-Milovancevic
    • , Marianne G Pedersen
    • , Carsten B Pedersen
    • , Andrew D Paterson
    • , Jeremy R Parr
    • , Alistair T Pagnamenta
    • , Guiomar Oliveira
    • , John I Nurnberger
    • , Merete Nordentoft
    • , Michael T Murtha
    • , Susana Mouga
    • , Ole Mors
    • , Eric M Morrow
    • , Daniel Moreno De Luca
    • , Anthony P Monaco
    • , Nancy Minshew
    • , Alison Merikangas
    • , William M McMahon
    • , Susan G McGrew
    • , Manuel Mattheisen
    • , Igor Martsenkovsky
    • , Donna M Martin
    • , Shrikant M Mane
    • , Pall Magnusson
    • , Catherine Lord
    • , Jonathan M Green
    • , Bridget Fernandez
    • , Bernie Devlin
    • , Patrícia B S Celestino-Soper
    • , Nadia Bolshakova
    • , Cátia Café
    • , Hakon Hakonarson
    • , David Amaral
    • , Elena Bacchelli
    • , Sabine M Klauck
    • , Marion Leboyer
    • , Hilary Coon
    • , Patrick F Bolton
    • , Arthur L Beaudet
    • , Richard Anney
    • , Joachim Hallmayer
    • , Sean Ennis
    • , David H Ledbetter
    • , Pat Levitt
    • , M Daniele Fallin
    • , Agatino Battaglia
    • , Michael L Cuccaro
    • , Anders D Børglum
    • , Maretha V De Jonge
    • , Aarno Palotie
    • , Raphael Bernier
    • , Silvia De Rubeis
    • , Frederico Duque
    • , Preben Bo Mortensen
    • , Daniel H Geschwind
    • , Dan E Arking
    • , Irva Hertz-Picciotto
    • , Jennifer K Lowe
    • , Stephan J Sanders
    • , Judith Conroy
    • , Alexander Kolevzon
    • , John Gilbert
    • , Anthony J Bailey
    • , Christopher Gillberg
    • , Vanessa H Bal
    • , Ann S Le Couteur
    • , Marie Bækvad-Hansen
    • , Christina M Hultman
    • , Jillian Casey
    • , Robert Hendren
    • , Christa Lese Martin
    • , Stephen J Guter
    • , Aravinda Chakravarti
    • , David Skuse
    • , Gillian Baird
    • , Sean Brennan
    • , George Davey Smith
    • , Tiago Magalhaes
    • , Rita M Cantor
    • , Somer Bishop
    • , Joel S Bader
    • , Edwin H Cook
    • , Joseph D Buxbaum
    • , Catalina Betancur
    • , Inês C Conceição
    • , Suma Jacob
    • , A Gulhan Ercan-Sencicek
    • , Catarina T Correia
    • , Susan E Folstein
    • , Jonathan L Haines
    • , Christine M Freitag
    • , Thomas Bourgeron
    • , Susan Santangelo
    • , Bozenna Iliadou
    • , Evdokia Anagnostou
    • , Mark J Daly
    • , Michael Gill
    • , Sven Bölte
    • , Elena Maestrini
    • , Andreas G Chiocchetti
    • , Joana Almeida
    • , Christine Ladd-Acosta
    • , Richard Delorme
    • , Eric Fombonne
    • , Louise Gallagher
    • , Dorothy E Grice
    • , Geraldine Dawson
    • , Christine S Hansen
    • , Elise B Robinson
    • , Arthur P Goldberg
    • , James S Sutcliffe
    • , Andrew Green
    •  & Eftichia Duketis
    Nature Genetics 49, 978–985
  • Research |

    Parental care in mice evolves through multiple genetic changes; one candidate is vasopressin, the reduced expression of which promotes parental nest-building behaviour in monogamous mice.

    • Andres Bendesky
    • , Young-Mi Kwon
    • , Jean-Marc Lassance
    • , Caitlin L. Lewarch
    • , Shenqin Yao
    • , Brant K. Peterson
    • , Meng Xiao He
    • , Catherine Dulac
    •  & Hopi E. Hoekstra
    Nature 544, 434–439

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