Biotechnology

Definition

Biotechnology is a broad discipline in which biological processes, organisms, cells or cellular components are exploited to develop new technologies. New tools and products developed by biotechnologists are useful in research, agriculture, industry and the clinic.

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Latest Research and Reviews

  • Research | | open

    Millions of enhancers are predicted, but their validation remains challenging. Here, the authors report genome-wide enhancer function quantification and high-resolution dissection for millions of accessible DNA fragments, revealing driver nucleotides and helping interpret non-coding disease variants.

    • Xinchen Wang
    • , Liang He
    • , Sarah M. Goggin
    • , Alham Saadat
    • , Li Wang
    • , Nasa Sinnott-Armstrong
    • , Melina Claussnitzer
    •  & Manolis Kellis
  • Research |

    Controlled tissue fixation with polyepoxides protects protein fluorescence, antigenicity, nucleic acids and tissue architecture.

    • Young-Gyun Park
    • , Chang Ho Sohn
    • , Ritchie Chen
    • , Margaret McCue
    • , Dae Hee Yun
    • , Gabrielle T Drummond
    • , Taeyun Ku
    • , Nicholas B Evans
    • , Hayeon Caitlyn Oak
    • , Wendy Trieu
    • , Heejin Choi
    • , Xin Jin
    • , Varoth Lilascharoen
    • , Ji Wang
    • , Matthias C Truttmann
    • , Helena W Qi
    • , Hidde L Ploegh
    • , Todd R Golub
    • , Shih-Chi Chen
    • , Matthew P Frosch
    • , Heather J Kulik
    • , Byung Kook Lim
    •  & Kwanghun Chung
  • Research | | open

    This paper presents standards and best practices for reporting genome sequences of uncultivated viruses.

    • Simon Roux
    • , Evelien M Adriaenssens
    • , Bas E Dutilh
    • , Eugene V Koonin
    • , Andrew M Kropinski
    • , Mart Krupovic
    • , Jens H Kuhn
    • , Rob Lavigne
    • , J Rodney Brister
    • , Arvind Varsani
    • , Clara Amid
    • , Ramy K Aziz
    • , Seth R Bordenstein
    • , Peer Bork
    • , Mya Breitbart
    • , Guy R Cochrane
    • , Rebecca A Daly
    • , Christelle Desnues
    • , Melissa B Duhaime
    • , Joanne B Emerson
    • , François Enault
    • , Jed A Fuhrman
    • , Pascal Hingamp
    • , Philip Hugenholtz
    • , Bonnie L Hurwitz
    • , Natalia N Ivanova
    • , Jessica M Labonté
    • , Kyung-Bum Lee
    • , Rex R Malmstrom
    • , Manuel Martinez-Garcia
    • , Ilene Karsch Mizrachi
    • , Hiroyuki Ogata
    • , David Páez-Espino
    • , Marie-Agnès Petit
    • , Catherine Putonti
    • , Thomas Rattei
    • , Alejandro Reyes
    • , Francisco Rodriguez-Valera
    • , Karyna Rosario
    • , Lynn Schriml
    • , Frederik Schulz
    • , Grieg F Steward
    • , Matthew B Sullivan
    • , Shinichi Sunagawa
    • , Curtis A Suttle
    • , Ben Temperton
    • , Susannah G Tringe
    • , Rebecca Vega Thurber
    • , Nicole S Webster
    • , Katrine L Whiteson
    • , Steven W Wilhelm
    • , K Eric Wommack
    • , Tanja Woyke
    • , Kelly C Wrighton
    • , Pelin Yilmaz
    • , Takashi Yoshida
    • , Mark J Young
    • , Natalya Yutin
    • , Lisa Zeigler Allen
    • , Nikos C Kyrpides
    •  & Emiley A Eloe-Fadrosh
  • Research |

    Segmental Duplication Assembler (SDA) uses long sequence reads to resolve segmental duplications that are collapsed in current genome assemblies. These assemblies correspond in total to the length of an average human chromosome.

    • Mitchell R. Vollger
    • , Philip C. Dishuck
    • , Melanie Sorensen
    • , AnneMarie E. Welch
    • , Vy Dang
    • , Max L. Dougherty
    • , Tina A. Graves-Lindsay
    • , Richard K. Wilson
    • , Mark J. P. Chaisson
    •  & Evan E. Eichler

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