Applied immunology

Definition

Applied immunology provides services to support the development of biological therapeutics such as monoclonal antibodies, vaccines and diagnostics. Applied immunology is a subdiscipline of immunology.

Latest Research and Reviews

  • Research | | open

    Viruses trigger potent cytotoxic T cell responses, whereas anti-tumour immunity has been difficult to establish. Here the authors engineer a replicating viral delivery system for tumour-associated antigens, which induces alarmin release, innate activation and protective anti-tumour immunity in mice.

    • Sandra M. Kallert
    • , Stephanie Darbre
    • , Weldy V. Bonilla
    • , Mario Kreutzfeldt
    • , Nicolas Page
    • , Philipp Müller
    • , Matthias Kreuzaler
    • , Min Lu
    • , Stéphanie Favre
    • , Florian Kreppel
    • , Max Löhning
    • , Sanjiv A. Luther
    • , Alfred Zippelius
    • , Doron Merkler
    •  & Daniel D. Pinschewer
  • Research | | open

    D-glutamate is an essential component of the bacterial cell wall. Here, the authors use mouse models of infection with Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus to show that bacterial mutants unable to synthesize D-glutamate can potentially be used as live attenuated vaccines.

    • Maria P. Cabral
    • , Patricia García
    • , Alejandro Beceiro
    • , Carlos Rumbo
    • , Astrid Pérez
    • , Miriam Moscoso
    •  & Germán Bou
  • Research | | open

    The WHO targets measles elimination by 2020, a goal that relies on high vaccination coverage. Here, Takahashi et al. identify ‘coldspots’ in the African Great Lakes region where measles vaccine coverage is below 80%, suggesting that these regions should be targeted in future vaccination campaigns.

    • Saki Takahashi
    • , C. Jessica E. Metcalf
    • , Matthew J. Ferrari
    • , Andrew J. Tatem
    •  & Justin Lessler
  • Research | | open

    Resident memory T cells (Trm) are memory T cells that remain in tissue. Here, the authors show that induction of Trm cells is required for control of tumour growth following mucosal vaccination in mice bearing head and neck cancer and that Trm cells in human lung cancer correlates with a better survival.

    • Mevyn Nizard
    • , Hélène Roussel
    • , Mariana O. Diniz
    • , Soumaya Karaki
    • , Thi Tran
    • , Thibault Voron
    • , Estelle Dransart
    • , Federico Sandoval
    • , Marc Riquet
    • , Bastien Rance
    • , Elie Marcheteau
    • , Elizabeth Fabre
    • , Marion Mandavit
    • , Magali Terme
    • , Charlotte Blanc
    • , Jean-Baptiste Escudie
    • , Laure Gibault
    • , Françoise Le Pimpec Barthes
    • , Clemence Granier
    • , Luis C. S. Ferreira
    • , Cecile Badoual
    • , Ludger Johannes
    •  & Eric Tartour
  • Research | | open

    The immunodominant epitope of dengue virus envelope protein (E) induces poorly neutralizing antibodies, which poses a problem for vaccine development. Here, the authors engineer covalently locked E dimers exposing an epitope that has been shown to induce potent and broadly neutralizing antibodies.

    • Alexander Rouvinski
    • , Wanwisa Dejnirattisai
    • , Pablo Guardado-Calvo
    • , Marie-Christine Vaney
    • , Arvind Sharma
    • , Stéphane Duquerroy
    • , Piyada Supasa
    • , Wiyada Wongwiwat
    • , Ahmed Haouz
    • , Giovanna Barba-Spaeth
    • , Juthathip Mongkolsapaya
    • , Félix A. Rey
    •  & Gavin R. Screaton
  • Research | | open

    Tumour-specific T cells can be expanded in vitro and adoptively transferred for therapy, but this strategy is limited by induction of short-lived T cell populations. Here the authors activate Notch signalling in cultured mouse or human T cells, resulting in the production of a long-lived stem cell memory T cell population that can fight tumours in mice.

    • Taisuke Kondo
    • , Rimpei Morita
    • , Yuumi Okuzono
    • , Hiroko Nakatsukasa
    • , Takashi Sekiya
    • , Shunsuke Chikuma
    • , Takashi Shichita
    • , Mitsuhiro Kanamori
    • , Masato Kubo
    • , Keiko Koga
    • , Takahiro Miyazaki
    • , Yoshiaki Kassai
    •  & Akihiko Yoshimura

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