The Art and Design of Genetic Screens
A collection of reviews from Nature Reviews Genetics. Select the links below for full-text access.
In this age of genomics, one could be forgiven for thinking that classical genetic screens are a thing of the past. But whereas genome projects provide us with an inventory of genes, genetic screens can provide important clues about what those genes do. When genetic screens are reported, the details of the screen itself are often overshadowed by the excitement surrounding the genes that are identified. But the way a screen is designed can profoundly influence which genes are uncovered, and the exquisite design of some genetic screens can inspire related experiments in other systems.
These reviews are intended to provide an up-to-date account of genetic screening in the main genetic experimental systems. By highlighting recent genetic screens, these articles will illustrate the elegance and power of genetic screens, and the thinking that underlies them.
Genetic screens can provide the first hint about the molecular events that underpin a particular biological process. The results are sometimes exhilarating and sometimes mundane - but if the screen is any good, they are usually biologically meaningful. Either way, genetic screens have a certain mystique, and for the foreseeable future, they are here to stay.
Index
2008
July 2008 Vol 9 No 7
THE ART AND DESIGN OF GENETIC SCREENS: RNA interference
Michael Boutros & Julie Ahringer
doi:10.1038/nrg2364
2008
March 2008 Vol 9 No 3
THE ART AND DESIGN OF GENETIC SCREENS: MAIZE
Héctor Candela & Sarah Hake
doi:10.1038/nrg2291
2005
July 2005 Vol 6 No 7
THE ART AND DESIGN OF GENETIC SCREENS: MOUSE
Benjamin T. Kile, Douglas J. Hilton
p557 | doi:10.1038/nrg1636
2004
March 2004 Vol 5 No 3
THE ART AND DESIGN OF GENETIC SCREENS: MAMMALIAN CULTURE CELLS
Stefan Grimm
p179 | doi:10.1038/nrg1291
2003
June 2003 Vol 4 No 6
THE ART AND DESIGN OF GENETIC SCREENS: ESCHERICHIA COLI
Howard A. Shuman & Thomas J. Shilhavy
p419 | doi:10.1038/nrg1087
2002
September 2002 Vol 3 No 9
THE ART AND DESIGN OF GENETIC SCREENS: FILAMENTOUS FUNGI
Lorna Casselton & Miriam Zolan
p683 | doi:10.1038/nrg889
May 2002 Vol 3 No 5
THE ART AND DESIGN OF GENETIC SCREENS: CAENORHABDITIS ELEGANS
Erik M. Jorgensen & Susan E. Mango
p356 | doi:10.1038/nrg794
March 2002 Vol 3 No 3
THE ART AND DESIGN OF GENETIC SCREENS: DROSOPHILA MELANOGASTER
Daniel St Johnston
p176 | doi:10.1038/nrg751
February 2002 Vol 3 No 2
THE ART AND DESIGN OF GENETIC SCREENS: ARABIDOPSIS THALIANA
Damian R. Page & Ueli Grossniklaus
p124 | doi:10.1038/nrg730
2001
December 2001 Vol 2 No 12
THE ART AND DESIGN OF GENETIC SCREENS: ZEBRAFISH
E. Elizabeth Patton & Leonard I. Zon
p956 | doi:10.1038/35103567
September 2001 Vol 2 No 9
THE ART AND DESIGN OF GENETIC SCREENS: YEAST
Susan L. Forsburg
p659 | doi:10.1038/35088500