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LATEST: 2007 impact factor 9.954 from Journal Citation Reports, Thomson 2008
Featured article
Membrane identity and GTPase cascades regulated by toggle and cut-out switches
Comparison of in vivo time course of protein densities on motile vesicles against predictions of 54 different kinetic models revealed that the GTPases Rab5 and Rab7, which organise early and late endosomes, respectively, exchange on the endosome membrane according to a newly identified cut-out switch mechanism, as opposed to a toggle switch mechanism, and thereby are able to reconcile organelle identity maintenance with identity progression.
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Research articles
Membrane identity and GTPase cascades regulated by toggle and cut-out switches
Perla Del Conte-Zerial, Lutz Brusch, Jochen C Rink, Claudio Collinet, Yannis Kalaidzidis, Marino Zerial & Andreas Deutsch
doi:10.1038/msb.2008.45
Published online: 15 July 2008
Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model
Francois-Pierre J Martin, Yulan Wang, Norbert Sprenger, Ivan K S Yap, Serge Rezzi, Ziad Ramadan, Emma Peré-Trepat, Florence Rochat, Christine Cherbut, Peter van Bladeren, Laurent B Fay, Sunil Kochhar, John C Lindon, Elaine Holmes & Jeremy K Nicholson
doi:10.1038/msb.2008.40
Published online: 15 July 2008
From E-MAPs to module maps: dissecting quantitative genetic interactions using physical interactions
Igor Ulitsky, Tomer Shlomi, Martin Kupiec & Ron Shamir
doi:10.1038/msb.2008.42
Published online: 15 July 2008
Parasites lead to evolution of robustness against gene loss in host signaling networks
Marcel Salathé & Orkun S Soyer
doi:10.1038/msb.2008.44
Published online: 15 July 2008
Gene network dynamics controlling keratinocyte migration
Hauke Busch, David Camacho-Trullio, Zbigniew Rogon, Kai Breuhahn, Peter Angel, Roland Eils & Axel Szabowski
doi:10.1038/msb.2008.36
Published online: 01 July 2008
Reverse engineering of force integration during mitosis in the Drosophila embryo
Roy Wollman, Gul Civelekoglu-Scholey, Jonathan M Scholey & Alex Mogilner
doi:10.1038/msb.2008.23
Published online: 06 May 2008
Reports
The incoherent feed-forward loop can generate non-monotonic input functions for genes
Shai Kaplan, Anat Bren, Erez Dekel & Uri Alon
doi:10.1038/msb.2008.43
Published online: 15 July 2008
Millimeter-scale genetic gradients and community-level molecular convergence in a hypersaline microbial mat
Victor Kunin, Jeroen Raes, J Kirk Harris, John R Spear, Jeffrey J Walker, Natalia Ivanova, Christian von Mering, Brad M Bebout, Norman R Pace, Peer Bork & Philip Hugenholtz
doi:10.1038/msb.2008.35
Published online: 03 June 2008
Gender-dependent progression of systemic metabolic states in early childhood
Janne Nikkilä, Marko Sysi-Aho, Andrey Ermolov, Tuulikki Seppänen-Laakso, Olli Simell, Samuel Kaski & Matej Orešič
doi:10.1038/msb.2008.34
Published online: 03 June 2008
Recursive construction of perfect DNA molecules from imperfect oligonucleotides
Gregory Linshiz, Tuval Ben Yehezkel, Shai Kaplan, Ilan Gronau, Sivan Ravid, Rivka Adar & Ehud Shapiro
doi:10.1038/msb.2008.26
Published online: 06 May 2008
News & Views
Comment on 'Dynamic analysis of optimality in myocardial energy metabolism under normal and ischemic conditions'
Daniel A Beard
doi:10.1038/msb.2008.37
Published online: 15 July 2008
In reply: 'Dynamic analysis of optimality in myocardial energy metabolism under normal and ischemic conditions'
Ruo-Yu Luo, Yi-Xue Li & Qingming Luo
doi:10.1038/msb.2008.38
Published online: 15 July 2008
When microarrays Met epidermal-cell migration
Kevin A Janes
doi:10.1038/msb.2008.41
Published online: 01 July 2008
A theoretical model of mitotic spindle elongation under experimental constraints
Thomas Surrey
doi:10.1038/msb.2008.33
Published online: 06 May 2008
Perspectives
Life Sciences and the web: a new era for collaboration
Jonathan A Sagotsky, Le Zhang, Zhihui Wang, Sean Martin & Thomas S Deisboeck
doi:10.1038/msb.2008.39
Published online: 01 July 2008
Understanding NF-κB signaling via mathematical modeling
Raymond Cheong, Alexander Hoffmann & Andre Levchenko
doi:10.1038/msb.2008.30
Published online: 06 May 2008
Reviews
Theoretical and experimental approaches to understand morphogen gradients
Marta Ibañes & Juan Carlos Izpisúa Belmonte
doi:10.1038/msb.2008.14
Published online: 25 March 2008
Corrigendum
Increased glycolytic flux as an outcome of whole-genome duplication in yeast
Gavin C Conant & Kenneth H Wolfe
doi:10.1038/msb200846
Published online: 01 July 2008
More systems biology from NPG & EMBO
A selection of relevant articles hosted by Nature Publishing Group are listed below. More articles can be found on the Systems biology Subject Area page.
