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Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin
We devised a method to measure quantitative relationships between mitotic cyclin levels and execution of multiple steps in mitotic exit. Undegradable mitotic cyclin slows mitotic exit in a dose dependent manner, but stable arrest requires more cyclin than is made during a normal cell cycle.
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Top 10 downloads
- Harnessing gene expression to identify the genetic basis of drug resistance
- Disease signatures are robust across tissues and experiments
- Listening to the noise: random fluctuations reveal gene network parameters
- Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression
- Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture
- Full top 10 list of downloads
Research articles
Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin
Benjamin J Drapkin, Ying Lu, Andrea L Procko, Benjamin L Timney & Frederick R Cross
doi:10.1038/msb.2009.78
Published online: 17 November 2009
Information processing and signal integration in bacterial quorum sensing
Pankaj Mehta, Sidhartha Goyal, Tao Long, Bonnie L Bassler & Ned S Wingreen
doi:10.1038/msb.2009.79
Published online: 17 November 2009
Dissection of a complex transcriptional response using genome-wide transcriptional modelling
Martino Barenco, Daniel Brewer, Efterpi Papouli, Daniela Tomescu, Robin Callard, Jaroslav Stark & Michael Hubank
doi:10.1038/msb.2009.84
Published online: 17 November 2009
Edgetic perturbation models of human inherited disorders
Quan Zhong, Nicolas Simonis, Qian-Ru Li, Benoit Charloteaux, Fabien Heuze, Niels Klitgord, Stanley Tam, Haiyuan Yu, Kavitha Venkatesan, Danny Mou, Venus Swearingen, Muhammed A Yildirim, Han Yan, Amélie Dricot, David Szeto, Chenwei Lin, Tong Hao, Changyu Fan, Stuart Milstein, Denis Dupuy, Robert Brasseur, David E Hill, Michael E Cusick & Marc Vidal
doi:10.1038/msb.2009.80
Published online: 3 November 2009
Reconstruction of the yeast Snf1 kinase regulatory network reveals its role as a global energy regulator
Renata Usaite, Michael C Jewett, Ana Paula Oliveira, John R Yates, III, Lisbeth Olsson & Jens Nielsen
doi:10.1038/msb.2009.67
Published online: 3 November 2009
Harnessing gene expression to identify the genetic basis of drug resistance
Bo-Juen Chen, Helen C Causton, Denesy Mancenido, Noel L Goddard, Ethan O Perlstein & Dana Pe'er
doi:10.1038/msb.2009.69
Published online: 13 October 2009
Ribosome and transcript copy numbers, polysome occupancy and enzyme dynamics in Arabidopsis
Maria Piques, Waltraud X Schulze, Melanie Höhne, Björn Usadel, Yves Gibon, Johann Rohwer & Mark Stitt
doi:10.1038/msb.2009.68
Published online: 13 October 2009
Viral adaptation to host: a proteome-based analysis of codon usage and amino acid preferences
Iris Bahir, Menachem Fromer, Yosef Prat & Michal Linial
doi:10.1038/msb.2009.71
Published online: 13 October 2009
Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway
Bryan W Miller, Garnet Lau, Chris Grouios, Emanuela Mollica, Miriam Barrios-Rodiles, Yongmei Liu, Alessandro Datti, Quaid Morris, Jeffrey L Wrana & Liliana Attisano
doi:10.1038/msb.2009.72
Published online: 13 October 2009
Reports
Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression
Larsson Omberg, Joel R Meyerson, Kayta Kobayashi, Lucy S Drury, John F X Diffley & Orly Alter
doi:10.1038/msb.2009.70
Published online: 13 October 2009
Quantitative effect of scaffold abundance on signal propagation
Stephen A Chapman & Anand R Asthagiri
doi:10.1038/msb.2009.73
Published online: 13 October 2009
The switching dynamics of the bacterial flagellar motor
Siebe B van Albada, Sorin Tănase-Nicola & Pieter Rein ten Wolde
doi:10.1038/msb.2009.74
Published online: 13 October 2009
Listening to the noise: random fluctuations reveal gene network parameters
Brian Munsky, Brooke Trinh & Mustafa Khammash
doi:10.1038/msb.2009.75
Published online: 13 October 2009
News & Views
Learning the transcriptional regulatory code
Alexander Stark
doi:10.1038/msb.2009.88
Published online: 17 November 2009
Getting an edge on human disease
Albertha J M Walhout
doi:10.1038/msb.2009.81
Published online: 3 November 2009
Reviews
Strategies for cellular decision-making
Theodore J Perkins & Peter S Swain
doi:10.1038/msb.2009.83
Published online: 17 November 2009
Applications of genome-scale metabolic reconstructions
Matthew A Oberhardt, Bernhard Ø Palsson & Jason A Papin
doi:10.1038/msb.2009.77
Published online: 3 November 2009
Perspectives
Shifts in growth strategies reflect tradeoffs in cellular economics
Douwe Molenaar, Rogier van Berlo, Dick de Ridder & Bas Teusink
doi:10.1038/msb.2009.82
Published online: 3 November 2009
Correspondence
Mitotic exit in mammalian cells
Orsolya Kapuy, Enuo He, Frank Uhlmann & Béla Novák
doi:10.1038/msb.2009.86
Published online: 3 November 2009
Editorials
Systems biology and the virtual physiological human
Peter Kohl & Denis Noble
doi:10.1038/msb.2009.51
Published online: 28 July 2009
More systems biology from NPG & EMBO
A selection of relevant articles hosted by Nature Publishing Group are listed below. More articles can be found on the Systems biology Subject Area page.
