Article series
An Article Series is a special series of articles that explores a specific theme and comprises Reviews and Perspectives that are published consecutively over a period of time.
Applications of next–generation sequencing
The power of high–throughput DNA sequencing technologies is being harnessed by researchers to address an increasingly diverse range of biological problems. The scale and efficiency of sequencing that can now be achieved is providing unprecedented progress in areas from the analysis of genomes themselves to how proteins interact with nucleic acids. This series highlights the breadth of next–generation sequencing applications and the importance of the insights that are being gained through these methods.
Genome-wide association studies
In the past 2 years genome-wide association studies in humans have revealed dozens of disease-associated loci and have provided insights into the allelic architecture of complex traits. Along the way, much has been learned about how best to carry out such studies. The articles in this series examine these design issues and the technical challenges that remain; for example, identifying association signals and interpreting the molecular mechanisms by which they exert their biological functions.
Modelling
An abundance of data and unprecedented computational power are allowing sophisticated biological models to be devised and tested. This series of articles examines how the coupling of genetics with disciplines such as engineering, statistics, physics and computational biology has enriched our understanding in areas that range from developmental patterning to genetic association analyses.
Fundamental concepts in genetics
Our understanding of heredity and the practice of genetic analysis are underpinned by certain fundamental concepts. Each article in this series examines one of these concepts, explaining how it works, how it has contributed to genetics and why it is of continuing importance today. The articles are designed both as an introduction to the concept and an analysis of the latest developments.
Historical profiles
Each article in this series of Timeline pieces � which have appeared in Nature Reviews Genetics from 2001 � depicts a historical figure (or figures) in genetics and how their ideas fit into a modern context. As well as revise our views of these scientists' contributions, the articles in this series also serve to acquaint our younger readers to the scientists who have shaped their field.
History of genetic disease
Each article in this series of Timeline pieces describes how our knowledge of an important human genetic disease has developed over the years. The articles are written by prominent figures in the field of human genetics who have witnessed much of the development of and personally contributed to the understanding of the diseases they describe.
Art and design of genetic screens
This is a series of articles that celebrates the art and design of genetic screens. These reviews are intended to provide an up-to-date account of genetic screening in the main genetic experimental systems.
