Nature Reviews Genetics
Volume 9, No 5 May 2008
Featured Article
Genome–wide association studies for complex traits: consensus, uncertainty and challenges
Mark I. McCarthy, Gonçalo R. Abecasis, Lon R. Cardon, David B. Goldstein, Julian Little, John P. A. Ioannidis & Joel N. Hirschhorn
2006 ISI Impact Factor 22.947(*Source of Impact Factor data)
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Review
Use and misuse of the gene ontology annotations
Seung Yon Rhee, Valerie Wood, Kara Dolinski & Sorin Draghici
The Gene Ontology project has provided a powerful tool for interpreting the biological significance of both experimental and computational data. However, some appreciation of how the database works is essential to avoid misinterpretations.
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Review
Genetic approaches to crop improvement: responding to environmental and population changes
Shin Takeda & Makoto Matsuoka
The combination of environmental change and a rapidly increasing human population is putting global food supplies in danger. Crop improvements that increase yields and enable plants to withstand abiotic stresses will provide an important route to tackling this urgent problem.
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Review
DNA methylation landscapes: provocative insights from epigenomics
Miho M. Suzuki & Adrian Bird
Rather than being a mark of irreversible gene silencing that localizes mainly to promoters and intergenic regions, epigenomics approaches are revealing DNA methylation as a surprisingly dynamic regulator of gene expression that might also have important roles within gene bodies.
ADVANCE ONLINE PUBLICATION
Review
Detecting genetic responses to environmental change
Ary A. Hoffmann & Yvonne Willi
Advances in genomics and gene mapping allow sets of candidate genes to be identified for use in monitoring adaptive responses to specific environmental stresses. Such toolkits will allow us to predict the ability of species to adapt to changing environments.
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Research Highlights
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Development:
Extending the role of FGFs in the limb
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An interview with...
Cliff Tabin
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Ethics watch:
Out of sequence: how consumer genomics could displace clinical genetics
NPG COLLECTION
MicroRNA and cancer
Nature Publishing Group presents a collection on microRNA and cancer, which includes Research Highlights, Reviews and primary research papers from Nature Reviews Genetics, Nature Reviews Cancer and Nature Genetics. The collection is freely available until 30 September 2008, thanks to the support from Exiqon.
More Genetics
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Recommended Links
Links recommended by the Editors
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Web Focus Collection
Selected articles from the Nature Publishing Group on key current topics
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Article Series
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Genetics Conferences
A calendar of forthcoming meetings and workshops from across the field of genetics and genomics.
Noticeboard
Milestones in DNA technologies
Nature Methods, Nature Reviews Genetics and Nature are proud to present The Nature Milestones in DNA technologies, a series of articles and commentaries highlighting the most influential developments in DNA–related techniques over the past half–century.
Visit the Milestones website made freely accessible thanks to the support of QIAGEN.
Focus on evo–devo
Evolutionary developmental biology (evo–devo) attempts to integrate an understanding of developmental processes into the Modern Synthesis of genetics and evolution, which classically focused on how allele frequencies changed in populations. This Focus examines some of the conceptual advances that evo–devo is offering to evolutionary biology as a whole, and looks at how both new approaches such as genomics and classical approaches such as palaeontology are supporting these advances.
Web focuses
A Web Focus is a selection of articles on a related theme drawn from the entire Nature Publishing Group family of journals. With content ranging from Research Highlights, Reviews and Perspectives through to primary research papers, a Web Focus provides a panoramic view of a key area of biology.
RNAi animation
Nature Reviews Genetics and Arkitek present an animation of the RNAi process. Click here for access to the accompanying RNAi Web Focus, which includes relevant content from across Nature Publishing Group.
Statistical genetics audio supplement
How will advances in statistics aid genetic analyses? Find out what the experts think in our Focus audio supplement: 'Genetics by numbers'
Nature Omics gateway
The Nature Omics gateway is a comprehensive compilation of large-scale genomic biology content, drawn from the complete range of Nature Publishing Group publications. Content includes research and review articles, news, commentaries and research highlights.
Journal Citation Reports, Thomson, 2007