Nature Methods - CURRENT ISSUE : November 2009 - Vol 6 No 11
- 4C-ing rearrangements
- Improved reprogramming of human cells
- Visual proteomics of Leptospira interrogans
Latest highlights
FOCUS
NGS data analysis
Online FocusFREE
To extract a maximum of information from next-generation sequencing data, users have to navigate a maze of different software options. A series of Reviews guides readers through the analysis steps for different applications and explains how different algorithms handle these steps.
SUPPLEMENT
Nature Milestones in Light Microscopy
Nature MilestonesFREE
The Nature Milestones in Light Microscopy supplement presents a historical overview of the key developments in light microscopy. From the first light microscopes over 400 years ago, to super-resolution imaging in the last decade, these technological developments have changed the way biologists work and point to continued advances in the future. A timeline and collection of short articles highlight these important developments.
ADVANCE ONLINE PUBLICATION
Tissue-specific miRNA sponges
Article by Loya et al.Tissue-specific expression of microRNA sponges allows precise regulation of microRNA activity in living flies. Van Vactor and colleagues investigate the role of miR-8 in the formation of neuromuscular junctions.
ADVANCE ONLINE PUBLICATION
Controlling degradation
Article by Nishimura et al.Kanemaki and colleagues show that a degradation pathway found in plants, dependent on the hormone auxin, can be transplanted and harnessed to induce rapid and reversible target protein degradation in both yeast and animal cells.
ADVANCE ONLINE PUBLICATION
Making molecular patterns
Article by Kress et al.Microsources positioned with holographic optical tweezers can establish a highly localized, three-dimensional chemical gradient that, Dufresne and colleagues show, allows the manipulation of polarization and migration in single cells.
RESEARCH HIGHLIGHTS
Deep tumour imaging
Faster than a speeding blood cellFREE
Researchers use optical frequency-domain imaging (OFDI) to image deep into the tumor microvasculature and lymphatic vessels, yielding images with unprecedented detail.
NEW ON METHAGORA
Consumer genetics
MethagoraFREE
The availability of direct-to-consumer genetic tests is expanding and generates much interest within the genetics and policy communities as well as among the public. Visit our blog to read our editorial on the topic.
As always, we welcome your comments on this and other posts!
Application Notes
SENSOLUX® stand-alone version: noninvasive determination of pH and DO in shake flasks
Go to the Application Notes database
See also this month:
Application Notes from BioTek, Epicentre Biotechnologies, Thermo Scientific, febit GmbH, Invitrogen, and Glen Mills.
