Review
Nature Reviews Genetics 6, 557-567 (July 2005) | doi:10.1038/nrg1636
Article series: The Art and Design of Genetic Screens
The art and design of genetic screens: mouse
Benjamin T. Kile1 & Douglas J. Hilton1 About the authors
Abstract
Humans are mammals, not bacteria or plants, yeast or nematodes, insects or fish. Mice are also mammals, but unlike gorilla and goat, fox and ferret, giraffe and jackal, they are suited perfectly to the laboratory environment and genetic experimentation. In this review, we will summarize the tools, tricks and techniques for executing forward genetic screens in the mouse and argue that this approach is now accessible to most biologists, rather than being the sole domain of large national facilities and specialized genetics laboratories.
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Author affiliations
- Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia.
Correspondence to: Benjamin T. Kile1 Email: kile@wehi.edu.au
Correspondence to: Douglas J. Hilton1 Email: hilton@wehi.edu.au
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