Review
Nature Reviews Genetics 3, 356-369 (May 2002) | doi:10.1038/nrg794
Article series: The Art and Design of Genetic Screens
The art and design of genetic screens: Caenorhabditis elegans
Erik M. Jorgensen1 & Susan E. Mango2 About the authors
Abstract
The nematode Caenorhabditis elegans was chosen as a model genetic organism because its attributes, chiefly its hermaphroditic lifestyle and rapid generation time, make it suitable for the isolation and characterization of genetic mutants. The most important challenge for the geneticist is to design a genetic screen that will identify mutations that specifically disrupt the biological process of interest. Since 1974, when Sydney Brenner published his pioneering genetic screen, researchers have developed increasingly powerful methods for identifying genes and genetic pathways in C. elegans.
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Author affiliations
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Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA.
Email: jorgensen@biology.utah.edu -
Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA.
Email: susan.mango@hci.utah.edu
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