Nature Reviews Genetics
Volume 10, No 12 December 2009
Also this month
Article series: Applications of next–generation sequencing
Article series: Modelling
Article series: Genome–wide association studies
Featured Article
Induced pluripotent stem cells and reprogramming: seeing the science through the hype
Juan Carlos Izpisúa Belmonte, James Ellis, Konrad Hochedlinger & Shinya Yamanaka
Main pages for finding content:
ADVANCE ONLINE PUBLICATION
Progress
Article series: Applications of next–generation sequencing
Prokaryotic transcriptomics: a new view on regulation, physiology and pathogenicity
Rotem Sorek & Pascale Cossart
Until recently, large–scale transcriptome studies in bacteria and archaea were limited by technical challenges, and there was a perception that microbial transcription was relatively simple compared with eukaryotic transcription. Now, prokaryotic transcriptomics is revealing unexpected aspects of transcriptional control, genome organization and non–coding RNAs.
CURRENT ISSUE
Review
Article series: Applications of next–generation sequencing
The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs
Alain Jacquier
Recent transcriptomic studies have revealed that diverse small RNAs are transcribed from the regions around gene promoters. This Review considers questions prompted by the discovery of these transcripts; for example, what is their origin and are they functional?
CURRENT ISSUE
Review
Vertebrate limb bud development: moving towards integrative analysis of organogenesis
Rolf Zeller, Javier López-Ríos & Aimée Zuniga
Vertebrate limb development is a classic developmental model. In this Review the authors discuss how existing models of this process might be integrated and might form a framework for a systems approach to understanding organogenesis.
CURRENT ISSUE
Review
Article series: Modelling
Synthetic biology: understanding biological design from synthetic circuits
Shankar Mukherji & Alexander van Oudenaarden
The article highlights how the process of engineering biological systems has contributed to our understanding of how endogenous systems are put together and function — from a quantitative description of gene expression and signal transduction to controlling spatial organization and cell–cell interactions.
CURRENT ISSUE
Poster
The pervasive and interleaved transcriptome
Thomas R. Gingeras
Using snapshots at different levels of resolution — from chromosomes down to a few nucleotides — this poster provides a window into the layers of complexity of eukaryotic transcriptomes and introduces novel transcriptional phenomena and types of RNA.
ADVANCE ONLINE PUBLICATION
Research Highlights
-
Human disease:
Edges, nodes and networks
-
Ageing:
The impact of shrinking telomeres
-
Gene expression:
Regulators hidden in human proteome
-
Evolution:
The routes of adaptation
More Genetics
-
Recommended Links
Links recommended by the Editors
-
Web Focus Collection
Selected articles from the Nature Publishing Group on key current topics
-
Article Series
-
Genetics Conferences
A calendar of forthcoming meetings and workshops from across the field of genetics and genomics.
Noticeboard
Nature Reviews Genetics is now on Twitter. Follow us to keep up–to–date with the latest content.
Web Collection on Influenza
Influenza pandemics occur with some frequency, as indicated by the recent outbreak of swine flu (influenza A (H1N1)). Learn more about influenza, previous 'flu pandemics, preventative measures against 'flu and how the spread of disease can be modelled and possibly predicted with these selected Nature Reviews Microbiology and Nature Reviews Genetics articles.
Supplement on genomic medicine in developing countries
This collection of Perspective articles describes human genome variation studies taking place in Mexico, India, Thailand, and South Africa. It discusses the challenges and opportunities facing these and other developing countries in harnessing genomics for the benefit of their populations.
Milestones in DNA technologies
Nature Methods, Nature Reviews Genetics and Nature are proud to present The Nature Milestones in DNA technologies, a series of articles and commentaries highlighting the most influential developments in DNA–related techniques over the past half–century.
Visit the Milestones website made freely accessible thanks to the support of QIAGEN.
Web focuses
A Web Focus is a selection of articles on a related theme drawn from the entire Nature Publishing Group family of journals. With content ranging from Research Highlights, Reviews and Perspectives through to primary research papers, a Web Focus provides a panoramic view of a key area of biology.
RNAi animation
Nature Reviews Genetics and Arkitek present an animation of the RNAi process. Click here for access to the accompanying RNAi Web Focus, which includes relevant content from across Nature Publishing Group.
Statistical genetics audio supplement
How will advances in statistics aid genetic analyses? Find out what the experts think in our Focus audio supplement: 'Genetics by numbers'
Nature Omics gateway
The Nature Omics gateway is a comprehensive compilation of large-scale genomic biology content, drawn from the complete range of Nature Publishing Group publications. Content includes research and review articles, news, commentaries and research highlights.
2008 Journal Citation Report (Thomson Reuters, 2009)
