Advance online publication

The latest articles are published online ahead of print (AOP) on a weekly basis. These online versions are definitive and may be cited using the digital object identifier (DOI).


22 May 2017

Research Highlights

Plant genetics: Spatial transcriptomics in plants | PDF (140 KB)

Published online: 22 May 2017 | doi:10.1038/nrg.2017.41

Cancer genomics: Tracking cancer evolution | PDF (1,306 KB)

Published online: 22 May 2017 | doi:10.1038/nrg.2017.43

Stem cells: The different flavours of iPS cells | PDF (203 KB)

Published online: 22 May 2017 | doi:10.1038/nrg.2017.42



Article series: Epigenetics

Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells

Olivier Cuvier & Beat Fierz

Published online: 22 May 2017 | doi:10.1038/nrg.2017.28

A full understanding of chromatin in diverse cellular processes requires the consideration of its dynamics, but most standard chromatin assays provide only a static snapshot. This Review describes various emerging methods for probing chromatin dynamics across a wide range of temporal and spatial scales, and discusses the resulting biological insights.


15 May 2017

Research Highlight

Technology: Nucleic acid detection — it's elementary with SHERLOCK! | PDF (94 KB)

Published online: 15 May 2017 | doi:10.1038/nrg.2017.40



The evolutionary significance of polyploidy

Yves Van de Peer, Eshchar Mizrachi & Kathleen Marchal

Published online: 15 May 2017 | doi:10.1038/nrg.2017.26

Polyploidy occurs frequently but is usually detrimental to survival; thus, few polyploids survive in the long term. Here, evidence linking the short-term evolutionary success of polyploids to environmental upheaval is reviewed and possible longer-term evolutionary benefits of polyploidy are discussed.


08 May 2017

Research Highlight

Genetic testing: The diagnostic power of RNA-seq | PDF (222 KB)

Published online: 08 May 2017 | doi:10.1038/nrg.2017.39



Comparative transcriptomics in human and mouse

Alessandra Breschi, Thomas R. Gingeras & Roderic Guigó

Published online: 08 May 2017 | doi:10.1038/nrg.2017.19

Next-generation sequencing technologies have enabled the comprehensive characterization of human and mouse genomes, including at the transcriptional level. This article reviews the degree of conservation of human and mouse transcriptomes, along with the challenges of identifying when the mouse is a suitable model of human physiology.

The origin of Metazoa: a unicellular perspective

Arnau Sebé-Pedrós, Bernard M. Degnan & Iñaki Ruiz-Trillo

Published online: 08 May 2017 | doi:10.1038/nrg.2017.21

Multicellular organisms rely on a complex interplay between diverse cell types, but how multicellularity evolved from unicellular ancestors has long been a debated research question. In this Review, the authors describe how comparative and functional genomics have provided valuable insights into the transition between unicellularity and multicellularity, including how various molecular networks have been adopted for multicellular life.


27 March 2017


Article series: Disease mechanisms

Functional variomics and network perturbation: connecting genotype to phenotype in cancer

Song Yi, Shengda Lin, Yongsheng Li, Wei Zhao, Gordon B. Mills & Nidhi Sahni

Published online: 27 March 2017 | doi:10.1038/nrg.2017.8

The abundance and heterogeneity of mutations in cancer create challenges for understanding their effects, but such functional characterization will be crucial for optimizing clinical care. In this Review, the authors discuss diverse computational tools and systems biology experimental strategies for elucidating the functional effects of cancer mutations, including consequences on gene regulation, protein structure and local and global perturbations of molecular interaction networks.


About AOP

Until print versions of AOP papers are published, they should be cited in the style "Nature Reviews Genetics AOP, published online day month year; doi:10.1038/nrgXXX". Once the print version (identical to the AOP) is published, it should be cited as follows: "Nature Reviews Genetics volume number, page range (year); doi:10.1038/nrgXXX".