Nature Genetics - Current issue : December 2009 - Vol 41 No 12
Latest highlights
Current issue
Structural variation and alloimmunity
Letter by Steven McCarrollSteven McCarroll and colleagues examine common gene deletions in sibling donor-recipient pairs that have undergone bone marrow transplantation. They find that risk of acute graft-versus-host disease is greater when there is a mismatch for homozygous deletion of UGT2B17.
Advance online publication
Exome sequencing
Article by Sarah NgMichael Bamshad, Jay Shendure and colleagues report the first application of exome resequencing to a mendelian disorder of unknown cause, Miller syndrome, and identify mutations in DHODH.
Current issue
Genetics of Parkinson's disease
Letter by Wataru SatakeTwo groups report independent genome-wide association studies of Parkinson's disease. Tatsushi Toda and colleagues investigate Parkinson's disease in the Japanese population and identify two new risk regions on 1q32 and 4p15. Andrew Singleton, Thomas Gasser and colleagues study Parkinson's disease among individuals of European ancestry and find associations at two loci, SNCA and MAPT, and provide supporting evidence for the newly discovered risk locus on 1q32.
Current issue
Genetics of IBD
Letter by Kouichi AsanoThree groups report independent genome-wide association studies of inflammatory bowel diseases. Michiaki Kubo and colleagues investigated ulcerative colitis in the Japanese population, the UK IBD Genetics Consortium and the Wellcome Trust Case Control Consortium 2 investigated ulcerative colitis in Europeans, and Hakon Hakonarson and colleagues investigated early-onset inflammatory bowel disease.
Current issue
Genetics of cisplatin ototoxicity
Letter by Colin RossColin Ross and colleagues report the association of variants in TPMT and COMT to cisplatin-induced hearing loss in children. Cisplatin is a widely used chemotherapeutic agent.
Current issue
ETS factors and renal morphogenesis
Article by Benson LuFrank Costantini and colleagues report the identification of the ETS transcription factors, Etv4 and Etv5, as key targets of Ret signaling during kidney branching morphogenesis.
