Latest Research

  • Article |

    Oncogenic dosage variation along distinct evolutionary routes defines fundamental aspects of pancreatic cancer biology and phenotypic diversification.

    • Sebastian Mueller
    • , Thomas Engleitner
    • , Roman Maresch
    • , Magdalena Zukowska
    • , Sebastian Lange
    • , Thorsten Kaltenbacher
    • , Björn Konukiewitz
    • , Rupert Öllinger
    • , Maximilian Zwiebel
    • , Alex Strong
    • , Hsi-Yu Yen
    • , Ruby Banerjee
    • , Sandra Louzada
    • , Beiyuan Fu
    • , Barbara Seidler
    • , Juliana Götzfried
    • , Kathleen Schuck
    • , Zonera Hassan
    • , Andreas Arbeiter
    • , Nina Schönhuber
    • , Sabine Klein
    • , Christian Veltkamp
    • , Mathias Friedrich
    • , Lena Rad
    • , Maxim Barenboim
    • , Christoph Ziegenhain
    • , Julia Hess
    • , Oliver M. Dovey
    • , Stefan Eser
    • , Swati Parekh
    • , Fernando Constantino-Casas
    • , Jorge de la Rosa
    • , Marta I. Sierra
    • , Mario Fraga
    • , Julia Mayerle
    • , Günter Klöppel
    • , Juan Cadiñanos
    • , Pentao Liu
    • , George Vassiliou
    • , Wilko Weichert
    • , Katja Steiger
    • , Wolfgang Enard
    • , Roland M. Schmid
    • , Fengtang Yang
    • , Kristian Unger
    • , Günter Schneider
    • , Ignacio Varela
    • , Allan Bradley
    • , Dieter Saur
    •  & Roland Rad
  • Letter |

    A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level.

    • Qicong Shen
    • , Qian Zhang
    • , Yang Shi
    • , Qingzhu Shi
    • , Yanyan Jiang
    • , Yan Gu
    • , Zhiqing Li
    • , Xia Li
    • , Kai Zhao
    • , Chunmei Wang
    • , Nan Li
    •  & Xuetao Cao
  • Article | | open

    An improved genome assembly for Schmidtea mediterranea shows that the genome is highly polymorphic and repetitive, and lacks multiple genes encoding core components of cell biological mechanisms.

    • Markus Alexander Grohme
    • , Siegfried Schloissnig
    • , Andrei Rozanski
    • , Martin Pippel
    • , George Robert Young
    • , Sylke Winkler
    • , Holger Brandl
    • , Ian Henry
    • , Andreas Dahl
    • , Sean Powell
    • , Michael Hiller
    • , Eugene Myers
    •  & Jochen Christian Rink
  • Article |

    Analysis and modelling of locomotor characteristics of two pursuit predator–prey pairs show that hunts at lower speeds enable prey to use their maximum manoeuvring capacity and favour prey survival.

    • Alan M. Wilson
    • , Tatjana Y. Hubel
    • , Simon D. Wilshin
    • , John C. Lowe
    • , Maja Lorenc
    • , Oliver P. Dewhirst
    • , Hattie L. A. Bartlam-Brooks
    • , Rebecca Diack
    • , Emily Bennitt
    • , Krystyna A. Golabek
    • , Roger C. Woledge
    • , J. Weldon McNutt
    • , Nancy A. Curtin
    •  & Timothy G. West
  • Letter |

    Mammalian mitochondria use folate-bound one-carbon units generated by the enzyme SHMT2 to methylate tRNA, and this modification is required for mitochondrial translation and thus oxidative phosphorylation.

    • Raphael J. Morscher
    • , Gregory S. Ducker
    • , Sophia Hsin-Jung Li
    • , Johannes A. Mayer
    • , Zemer Gitai
    • , Wolfgang Sperl
    •  & Joshua D. Rabinowitz
  • Article | | open

    Sequencing and assembly of the 32-Gb genome of the Mexican axolotl reveals that it lacks the developmental gene Pax3, which is essential in other vertebrates; the genome sequence could improve our understanding of the evolution of the axolotl’s remarkable regenerative capabilities.

    • Sergej Nowoshilow
    • , Siegfried Schloissnig
    • , Ji-Feng Fei
    • , Andreas Dahl
    • , Andy W. C. Pang
    • , Martin Pippel
    • , Sylke Winkler
    • , Alex R. Hastie
    • , George Young
    • , Juliana G. Roscito
    • , Francisco Falcon
    • , Dunja Knapp
    • , Sean Powell
    • , Alfredo Cruz
    • , Han Cao
    • , Bianca Habermann
    • , Michael Hiller
    • , Elly M. Tanaka
    •  & Eugene W. Myers
  • Letter |

    By periodically modulating the position of degenerate fermions unidirectionally in a three-dimensional optical lattice, antiferromagnetic correlations in this many-body system can be reduced, enhanced or even switched to ferromagnetic correlations.

    • Frederik Görg
    • , Michael Messer
    • , Kilian Sandholzer
    • , Gregor Jotzu
    • , Rémi Desbuquois
    •  & Tilman Esslinger
  • Letter |

    Photophoretic optical trapping of cellulose particles and persistence of vision are used to produce real-space volumetric images that can be viewed from all angles, in geometries unachievable by holograms and light-field technologies.

    • D. E. Smalley
    • , E. Nygaard
    • , K. Squire
    • , J. Van Wagoner
    • , J. Rasmussen
    • , S. Gneiting
    • , K. Qaderi
    • , J. Goodsell
    • , W. Rogers
    • , M. Lindsey
    • , K. Costner
    • , A. Monk
    • , M. Pearson
    • , B. Haymore
    •  & J. Peatross

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Drugs that mobilize our immune systems against cancer are dramatically improving care for many people, and research is rapidly moving ahead in the lab and the clinic.

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