During starvation, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) targets GTPase-activating proteins to inhibit multiple intracellular transport pathways, thereby promoting energy homeostasis.

A silcrete flake with a 73,000-year-old cross-hatched ochre drawing, from Blombos Cave, South Africa, demonstrates that early Homo sapiens used a range of media and techniques to produce graphic representations.

The tumour microenvironment determines which type of liver cancer develops, with transformed hepatocytes giving rise to intrahepatic cholangiocarcinoma or hepatocellular carcinoma depending or whether they are surrounded by cells undergoing necroptosis or apoptosis.

The topological magnet Fe₃Sn₂ exhibits a giant nematic energy shift of a many-body electronic state, demonstrating anisotropic spin–orbit tunability.

Tools are embodied by the human somatosensory system, serving as sensory extensions of the human body.

A strategy developed to define off-target effects of gene-editing nucleases in whole organisms is validated and leveraged to show that CRISPR–Cas9 nucleases can be used effectively in vivo without inducing detectable off-target mutations.

A global modelling approach shows that in response to rises in global sea level, gains of up to 60% in coastal wetland areas are possible, if appropriate coastal management solutions are developed to help support wetland resilience.

Somatosensory corticospinal neurons facilitate touch sensitivity and touch-evoked neuropathic pain in mice.

Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.

Gene editing has now been used to introduce every possible single-nucleotide mutation into key protein-coding regions in the cancer-predisposition gene BRCA1, to identify the variants that are linked to cancer risk.

Controlled long-distance transport of electron spins is required for a kind of electronics known as spintronics. Such transport has been realized in an antiferromagnet, the most common type of magnetic material.

Some bacteria make energy in a process that is accompanied by transfer of electrons to a mineral. A previously unknown electron-transfer pathway now reveals an energy-generation system used by bacteria in the human gut.

Computational simulations suggest that future losses of tidal wetlands attributable to sea-level rise could be greatly offset by the landward advance of these ecosystems into newly sea-inundated areas.

A computational method has been devised that allows a structural motif found in proteins, known as a β-barrel, to be designed to bind specifically to any small molecule, opening the door to biotechnological applications.

How the same type of cell can form different kinds of tumour isn’t always clear. The discovery that cancer subtype in mice is influenced by the type of cell death occurring in the microenvironment provides some insight.

NASA mission will measure changes in ice thickness in unprecedented detail.

Experimental spacecraft will fling a net and shoot a spear at targets in space.

Machine learning supports 20-year-old theory of electron behaviour in high-temperature superconductor.

President Macron’s acknowledgement that the army killed Maurice Audin prompts wider admission that torture was ‘legally’ used during the conflict.

But nearly 70% of industry-sponsored trials report their results within a year of ending.

The funding by businesses dipped after the crash, offset in some regions by rises in government funding.