Featured
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Immunosuppressive effect of small extracellular vesicle PD-L1 is restricted by co-expression of CD80
- Jin-Yuan Liu
- , Zi-Li Yu
- & Gang Chen
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The effect of time before diagnosis and treatment on colorectal cancer outcomes: systematic review and dose–response meta-analysis
- Allison Drosdowsky
- , Karen E. Lamb
- & Jon D. Emery
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Correspondence |
Can TILs supplement the TNM staging system (as TNM-Immune)?
- Alhadi Almangush
- , Antti A. Mäkitie
- & Ilmo Leivo
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Immune microenvironment and lymph node yield in colorectal cancer
- Soo Hyun Lee
- , Amaya Pankaj
- & Osman Yılmaz
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| Open AccessAlterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy
- Nicola Gaynor
- , Alfonso Blanco
- & Denis M. Collins
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Article
| Open AccessThe emergence of RAS mutations in patients with RAS wild-type mCRC receiving cetuximab as first-line treatment: a noninterventional, uncontrolled multicenter study
- Hsiang-Lin Tsai
- , Chun-Chi Lin
- & Jaw-Yuan Wang
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Article
| Open AccessPamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-expansion stage of a multicentre, open-label, phase I trial
- Michael Friedlander
- , Linda Mileshkin
- & Alexander Spira
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Review Article |
PD-1 receptor outside the main paradigm: tumour-intrinsic role and clinical implications for checkpoint blockade
- C. Donini
- , F. Galvagno
- & D. Sangiolo
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Article |
Nicardipine is a putative EED inhibitor and has high selectivity and potency against chemoresistant prostate cancer in preclinical models
- Xin Li
- , Yanhua Chen
- & Daqing Wu
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Article
| Open AccessA real-world study of the first use of palbociclib for the treatment of advanced breast cancer within the UK National Health Service as part of the novel Ibrance® Patient Program
- Carlo Palmieri
- , Alison Musson
- & Ruhe Chowdhury
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Article
| Open AccessExposure to benzene and other hydrocarbons and risk of bladder cancer among male offshore petroleum workers
- Nita K. Shala
- , Jo S. Stenehjem
- & Tom K. Grimsrud
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Review Article
| Open AccessResistance to immune checkpoint therapies by tumour-induced T-cell desertification and exclusion: key mechanisms, prognostication and new therapeutic opportunities
- Mona Meng Wang
- , Sarah E. Coupland
- & Carlos R. Figueiredo
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Review Article |
The prognostic and biology of tumour-infiltrating lymphocytes in the immunotherapy of cancer
- Yanbin Liu
- , Zhenjiang Liu
- & Yarong Liu
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Correspondence |
Prognostic benefit of TILs independent of clinicopathological and molecular factors
- Koen Brummel
- , Anneke L. Eerkens
- & Hans W. Nijman
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Article
| Open AccessMiR-662 is associated with metastatic relapse in early-stage breast cancer and promotes metastasis by stimulating cancer cell stemness
- Margherita Puppo
- , Manoj Kumar Valluru
- & Philippe Clézardin
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Review Article |
Immunogenomic profiles associated with response to life-prolonging agents in prostate cancer
- Vincenza Conteduca
- , Nicole Brighi
- & Ugo De Giorgi
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Article |
Immunohistochemical characterisation of the immune landscape in primary uveal melanoma and liver metastases
- Pascale Mariani
- , Nouritza Torossian
- & Raymond Barnhill
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Article
| Open AccessC-type lectin receptor Dectin-1 blockade on tumour-associated macrophages improves anti-PD-1 efficacy in gastric cancer
- Xin Liu
- , Kunpeng Lv
- & Jiejie Xu
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Article
| Open AccessThromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial
- Nalinie Joharatnam-Hogan
- , Duaa Hatem
- & Ruth E. Langley
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Review Article |
Radiogenomics: a key component of precision cancer medicine
- Zaoqu Liu
- , Tian Duan
- & Xinwei Han
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Correspondence |
ACE inhibitors and the risk of lung cancer—is there causality?
- Martin H. Strauss
- , Ilke Sipahi
- & Alistair S. Hall
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Article
| Open AccessRational design of PD-1-CD28 immunostimulatory fusion proteins for CAR T cell therapy
- Theo Lorenzini
- , Bruno L. Cadilha
- & Sebastian Kobold
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Article
| Open AccessGenome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy
- Zijing Zhang
- , Meng Zhang
- & Donglai Wang
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Article |
HDAC5 modulates SATB1 transcriptional activity to promote lung adenocarcinoma
- Shalakha Sharma
- , Witty Tyagi
- & Sanjeev Das
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Article |
Ponatinib delays the growth of solid tumours by remodelling immunosuppressive tumour microenvironment through the inhibition of induced PD-L1 expression
- Anjali Barnwal
- , Rohini Tamang
- & Jayanta Bhattacharyya
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Article
| Open AccessComputational textural mapping harmonises sampling variation and reveals multidimensional histopathological fingerprints
- Otso Brummer
- , Petri Pölönen
- & Oscar Brück
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Article
| Open AccessEfficacy evaluation of chimeric antigen receptor-modified human peritoneal macrophages in the treatment of gastric cancer
- Xuhui Dong
- , Jiqiang Fan
- & Yuncheng Bei
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Article
| Open AccessArginine regulates HSPA5/BiP translation through ribosome pausing in triple-negative breast cancer cells
- Christina M. Vidal
- , Ching Ouyang
- & David K. Ann
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Article
| Open AccessChromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28
- Shujun Zhang
- , Peilong Li
- & Chuanxin Wang
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Article
| Open AccessProbing the diabetes and colorectal cancer relationship using gene – environment interaction analyses
- Niki Dimou
- , Andre E. Kim
- & Ulrike Peters
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Article |
Insulin receptor expression to predict resistance to axitinib and elucidation of the underlying molecular mechanism in metastatic renal cell carcinoma
- Masayuki Takahashi
- , Kei Daizumoto
- & Hiroomi Kanayama
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Review Article |
Whole tumour cell-based vaccines: tuning the instruments to orchestrate an optimal antitumour immune response
- Amarilis Pérez-Baños
- , María Alejandra Gleisner
- & Flavio Salazar-Onfray
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Article
| Open AccessEndogenous estrogen receptor modulating oxysterols and breast cancer prognosis: Results from the MARIE patient cohort
- Nina Sophia Decker
- , Theron Johnson
- & Renée Turzanski Fortner
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Review Article |
Rethinking our approach to cancer metabolism to deliver patient benefit
- Saverio Tardito
- & Craig MacKay
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Article |
Serum 25-hydroxyvitamin D concentrations and colorectal cancer incidence in adults with type 2 diabetes
- Jiao-Jiao Ren
- , Zhi-Hao Li
- & Chen Mao
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Correspondence |
Pan-cancer analysis of TRPV2 identifies its potential role as a prognostic and immunologic biomarker in oesophageal cancer
- Hang Yi
- , Yiwen Lin
- & Yousheng Mao
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Article |
Relationship between the expression of PD-L1 and 18F-FDG uptake in pancreatic ductal adenocarcinoma
- Jiajin Li
- , Ruohua Chen
- & Jianjun Liu
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Review Article
| Open AccessLocal γδ T cells: translating promise to practice in cancer immunotherapy
- Iva Zlatareva
- & Yin Wu
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Article
| Open AccessWhat do women think about having received their breast cancer risk as part of a risk-stratified NHS Breast Screening Programme? A qualitative study
- Lorna McWilliams
- , Helen Ruane
- & David P. French
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Article |
Pembrolizumab alone and pembrolizumab plus chemotherapy in previously treated, extrapulmonary poorly differentiated neuroendocrine carcinomas
- Nitya Raj
- , Jennifer A. Chan
- & Emily K. Bergsland
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Article
| Open AccessTargeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype
- Marianna Aprile
- , Simona Cataldi
- & Valerio Costa
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Article |
NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination
- Qian Cheng
- , Shanglei Ning
- & Jiye Zhu
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Article |
‘Evaluation of adverse prognostic gene alterations & MRD positivity in BCR::ABL1-like B-lineage acute lymphoblastic leukaemia patients, in a resource-constrained setting
- Dikshat Gopal Gupta
- , Neelam Varma
- & Subhash Varma
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Article |
Chemoradiotherapy versus triplet chemotherapy as initial therapy for T4b esophageal cancer: survival results from a multicenter randomized Phase 2 trial
- Makoto Yamasaki
- , Hiroshi Miyata
- & Yuichiro Doki
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Article
| Open AccessNK cell activity and methylated HOXA9 ctDNA as prognostic biomarkers in patients with non-small cell lung cancer treated with PD-1/PD-L1 inhibitors
- Sara Witting Christensen Wen
- , Line Nederby
- & Torben Frøstrup Hansen
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Editorial |
Precision medicine for prostate cancer—improved outcome prediction for low-intermediate risk disease using a six-gene copy number alteration classifier
- William Lautert-Dutra
- , Rodolfo Borges dos Reis
- & Jeremy A. Squire
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Article
| Open AccessIn silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer
- Marcos Quintela
- , David W. James
- & Lewis W. Francis
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Article
| Open AccessIntegrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma
- Arlou Kristina Angeles
- , Florian Janke
- & Holger Sültmann
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Article
| Open AccessAnticipating changes in the HER2 status of breast tumours with disease progression—towards better treatment decisions in the new era of HER2-low breast cancers
- Anthony Bergeron
- , Aurélie Bertaut
- & Laurent Arnould
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