This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Data availability
Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
References
Almangush A, Mäkitie AA, Leivo I. Can TILs supplement the TNM staging system (as TNM-Immune)?
Brummel K, Eerkens AL, de Bruyn M, Nijman HW. Tumour-infiltrating lymphocytes: from prognosis to treatment selection. Br J Cancer. 2023;188:451–8.
Ward MJ, Thirdborough SM, Mellows T, Riley C, Harris S, Suchak K, et al. Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer. Br J Cancer. 2014;110:489–500.
Wakeham K, Murray L, Muirhead R, Hawkins MA, Sebag-Montefiore D, Brown S, et al. Multicentre investigation of prognostic factors incorporating p16 and tumour infiltrating lymphocytes for anal cancer after chemoradiotherapy. Clin Oncol. 2021;33:638–49.
Getz G, Gabriel SB, Cibulskis K, Lander E, Sivachenko A, Sougnez C, et al. Integrated genomic characterization of endometrial carcinoma. Nature. 2013;497:67–73.
Horeweg N, Workel HH, Loiero D, Church DN, Vermij L, Léon-Castillo A, et al. Tertiary lymphoid structures critical for prognosis in endometrial cancer patients. Nat Commun. 2022;13:1373.
Horeweg N, de Bruyn M, Nout RA, Stelloo E, Kedzierska K, León-Castillo A, et al. Prognostic integrated image-based immune and molecular profiling in early-stage endometrial cancer. Cancer Immunol Res. 2020;8:1508–19.
Lee M, Park IA, Heo SH, Kim YA, Gong G, Lee HJ. Association between p53 expression and amount of tumor-infiltrating lymphocytes in triple-negative breast cancer. J Pathol Transl Med. 2019;53:180–7.
Funding
Not applicable.
Author information
Authors and Affiliations
Contributions
KB and ALE drafted and revised the manuscript. MB and HWN conceived the project, supervised writing, and revised the manuscript. All authors read and approved the final version.
Corresponding author
Ethics declarations
Competing interests
HWN and MdB hold a patent on antibodies targeting CD103 (no 62/704,258).
Ethics approval and consent to participate
Not applicable.
Consent for publication
All authors have approved to publish this manuscript.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Brummel, K., Eerkens, A.L., de Bruyn, M. et al. Prognostic benefit of TILs independent of clinicopathological and molecular factors. Br J Cancer 129, 737–738 (2023). https://doi.org/10.1038/s41416-023-02335-6
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41416-023-02335-6