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| Open AccessSingle-cell RNA sequencing analysis of vestibular schwannoma reveals functionally distinct macrophage subsets
- Paramita Baruah
- , Christopher Mahony
- & Adam P. Croft
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Article
| Open AccessAnti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis
- Masataka Yokode
- , Masahiro Shiokawa
- & Hiroshi Seno
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IL-24 improves efficacy of CAR-T cell therapy by targeting stemness of tumor cells
- Kai Zhang
- , Wenhao Hu
- & Yi Zhang
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Article
| Open AccessSerum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study
- Takuro Saito
- , Yukinori Kurokawa
- & Yuichiro Doki
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Article
| Open AccessLong-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus
- Masashi Hashimoto
- , Shinji Kuroda
- & Toshiyoshi Fujiwara
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| Open AccessImmune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8+ T cell infiltration
- Masaya Kanahori
- , Eijiro Shimada
- & Yasuharu Nakashima
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Enhanced antitumour response of gold nanostar-mediated photothermal therapy in combination with immunotherapy in a mouse model of colon carcinoma
- Hsin-Hua Hsieh
- , Chuan-Lin Chen
- & Chun-Yi Wu
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Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer
- Emre Küçükköse
- , Matthijs J. D. Baars
- & Yvonne Vercoulen
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Frequency of peripheral PD-1+regulatory T cells is associated with treatment responses to PARP inhibitor maintenance in patients with epithelial ovarian cancer
- Junsik Park
- , Jung Chul Kim
- & Jung-Yun Lee
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Article
| Open AccessEvaluation of tumour infiltrating lymphocytes in luminal breast cancer using artificial intelligence
- Shorouk Makhlouf
- , Noorul Wahab
- & Emad Rakha
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Blocking of oestrogen signals improves anti-tumour effect regardless of oestrogen receptor alpha expression in cancer cells
- Nabeel Kajihara
- , Yunqi Ge
- & Ken-ichiro Seino
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Article |
Immune microenvironment and lymph node yield in colorectal cancer
- Soo Hyun Lee
- , Amaya Pankaj
- & Osman Yılmaz
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Article
| Open AccessAlterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy
- Nicola Gaynor
- , Alfonso Blanco
- & Denis M. Collins
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Review Article |
PD-1 receptor outside the main paradigm: tumour-intrinsic role and clinical implications for checkpoint blockade
- C. Donini
- , F. Galvagno
- & D. Sangiolo
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Review Article
| Open AccessResistance to immune checkpoint therapies by tumour-induced T-cell desertification and exclusion: key mechanisms, prognostication and new therapeutic opportunities
- Mona Meng Wang
- , Sarah E. Coupland
- & Carlos R. Figueiredo
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Review Article |
The prognostic and biology of tumour-infiltrating lymphocytes in the immunotherapy of cancer
- Yanbin Liu
- , Zhenjiang Liu
- & Yarong Liu
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Correspondence |
Prognostic benefit of TILs independent of clinicopathological and molecular factors
- Koen Brummel
- , Anneke L. Eerkens
- & Hans W. Nijman
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Review Article |
Immunogenomic profiles associated with response to life-prolonging agents in prostate cancer
- Vincenza Conteduca
- , Nicole Brighi
- & Ugo De Giorgi
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Article |
Immunohistochemical characterisation of the immune landscape in primary uveal melanoma and liver metastases
- Pascale Mariani
- , Nouritza Torossian
- & Raymond Barnhill
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Article
| Open AccessC-type lectin receptor Dectin-1 blockade on tumour-associated macrophages improves anti-PD-1 efficacy in gastric cancer
- Xin Liu
- , Kunpeng Lv
- & Jiejie Xu
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Article
| Open AccessRational design of PD-1-CD28 immunostimulatory fusion proteins for CAR T cell therapy
- Theo Lorenzini
- , Bruno L. Cadilha
- & Sebastian Kobold
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Review Article |
Whole tumour cell-based vaccines: tuning the instruments to orchestrate an optimal antitumour immune response
- Amarilis Pérez-Baños
- , María Alejandra Gleisner
- & Flavio Salazar-Onfray
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Review Article
| Open AccessLocal γδ T cells: translating promise to practice in cancer immunotherapy
- Iva Zlatareva
- & Yin Wu
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Article
| Open AccessNK cell activity and methylated HOXA9 ctDNA as prognostic biomarkers in patients with non-small cell lung cancer treated with PD-1/PD-L1 inhibitors
- Sara Witting Christensen Wen
- , Line Nederby
- & Torben Frøstrup Hansen
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Article
| Open AccessSpatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
- Hanna Elomaa
- , Maarit Ahtiainen
- & Juha P. Väyrynen
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Prevalence of tumour-infiltrating CD103+ cells identifies therapeutic-sensitive prostate cancer with poor clinical outcome
- Quan Zhou
- , Yuxi Ou
- & Haowen Jiang
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Article |
Tumour-derived small extracellular vesicles contribute to the tumour progression through reshaping the systemic immune macroenvironment
- Zhimin Du
- , Hui Zhang
- & Jinheng Wang
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Article
| Open AccessSomatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens
- Takamasa Ishino
- , Shusuke Kawashima
- & Yosuke Togashi
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Article
| Open AccessIncreased cross-presentation by dendritic cells and enhanced anti-tumour therapy using the Arp2/3 inhibitor CK666
- Mariana M. S. Oliveira
- , Roberta D’Aulerio
- & Lisa S. Westerberg
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Correspondence |
Comment on: “Evolving roles of CD38 metabolism in solid tumour microenvironment”
- Pavel Nesmiyanov
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Review Article
| Open AccessTumour-infiltrating lymphocytes: from prognosis to treatment selection
- Koen Brummel
- , Anneke L. Eerkens
- & Hans W. Nijman
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Article |
Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours
- Yuto Watanabe
- , Tomohide Tsukahara
- & Toshihiko Torigoe
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Article
| Open AccessIncorporating weekly carboplatin in anthracycline and paclitaxel-containing neoadjuvant chemotherapy for triple-negative breast cancer: propensity-score matching analysis and TIL evaluation
- Maria Vittoria Dieci
- , Luisa Carbognin
- & Valentina Guarneri
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Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil
- Bingxue Yang
- , Xinran Xie
- & Shiyi Zhang
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Article
| Open AccessImpact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function
- Matthias Seifert
- , Mohamed-Reda Benmebarek
- & Sebastian Kobold
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Article
| Open AccessSerplulimab, a novel anti-PD-1 antibody, in patients with microsatellite instability-high solid tumours: an open-label, single-arm, multicentre, phase II trial
- Shukui Qin
- , Jin Li
- & Jun Zhu
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Article
| Open AccessIdentification of a high-risk immunogenic prostate cancer patient subset as candidates for T-cell engager immunotherapy and the introduction of a novel albumin-fused anti-CD3 × anti-PSMA bispecific design
- Eske N. Glud
- , Martin Rasmussen
- & Kenneth A. Howard
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Article
| Open AccessFAK promotes stromal PD-L2 expression associated with poor survival in pancreatic cancer
- Catherine Davidson
- , David Taggart
- & Alan Serrels
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Article
| Open AccessTreg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion
- Sarah N. Lauder
- , Kathryn Smart
- & Awen Gallimore
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Article |
A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer
- Kaisa Cui
- , Surui Yao
- & Zhaohui Huang
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Article |
Somatic mutations in DCC are associated with genomic instability and favourable outcomes in melanoma patients treated with immune checkpoint inhibitors
- Yuting Li
- , Qinghua Wang
- & Lujun Zhao
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Article
| Open AccessComprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk
- Mathilde M. Almekinders
- , Tycho Bismeijer
- & Alastair M. Thompson
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Article |
Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer
- Kalika Kamat
- , Venkatesh Krishnan
- & Oliver Dorigo
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Review Article |
Challenges in glioblastoma immunotherapy: mechanisms of resistance and therapeutic approaches to overcome them
- Karl John Habashy
- , Rana Mansour
- & Michel J. Massaad
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Article
| Open AccessRegulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma
- Daisuke Konishi
- , Yuzo Umeda
- & Toshiyoshi Fujiwara
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Article
| Open AccessModelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells
- Guoying Zhou
- , Ruby Lieshout
- & Jaap Kwekkeboom
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Article
| Open AccessSTAT1 is regulated by TRIM24 and promotes immunosuppression in head and neck squamous carcinoma cells, but enhances T cell antitumour immunity in the tumour microenvironment
- Kelvin Anderson
- , Nathan Ryan
- & Steve Oghumu
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Article
| Open AccessCXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in ovarian cancer
- Stefanie Seitz
- , Tobias F. Dreyer
- & Holger Bronger
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