A new method is described that uses arenium-ion-catalysed halodealkylation of silanes with four alkyl groups, typically considered synthetic dead ends, to convert Me₄Si and related quaternary silanes into orthogonally substituted (functionalized) silanes.

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

A computational approach to generate reference-free protein families from the sequence space in metagenomes reveals an enormously diverse functional space.

Dipolar precipitation change in High Mountain Asia during summer is primarily driven by weakened westerly jet and decadal variations in the South Asian monsoon, and the dipolar pattern is projected to shift to a monopolar wetting trend in the 2040s.

During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the cGAS–STING pathway, a major regulator of the senescence-associated secretory phenotype.