A rapid and efficient method developed to create stem-cell-based 3D mini-organs derived from the cells of patients offers a way to evaluate personalized treatments using RNA therapies for rare genetic diseases.

A multi-ancestry genome-wide study of 158,036 people with bipolar disorder and 2,796,499 control individuals identified 298 genomic regions associated with the disease. Variations in 36 genes were linked to the condition, and this variation was enriched in certain neuronal cell populations. The genetic architecture underlying bipolar disorder varied with subtype and how cases were identified.

Rubisco is the enzyme responsible for carbon fixation in plants, algae and many bacteria. A screen of a comprehensive library of rubisco variants (each with a different single-amino-acid mutation), expressed in engineered bacteria, identifies several mutations that improve the enzyme’s affinity for carbon dioxide.

In certain crystals, quasiparticles called Weyl fermions emerge from the collective quantum behaviour of electrons. However, these quasiparticles typically coexist with undesired conventional electronic states. After a decade-long search, physicists have engineered a crystal without conventional electronic states and with quantum properties governed entirely by Weyl fermions. Such materials could be useful for detecting and generating terahertz light.