Coloured transmission electron micrograph of Islets of Langerhans from a human pancreas shown in pink, purple, cyan and orange colours

Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection

Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.

Advertisement

  • Experimental tests and computational simulations of a scaled-down specimen of a real steel truss bridge identify and characterize the latent resistance mechanisms following critical failures, demonstrating how loads supported by failed components can be redistributed and enable structure resilience.

    • Juan C. Reyes-Suárez
    • Manuel Buitrago
    • Jose M. Adam
    ArticleOpen Access
  • DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, highlighting its essential role in proliferation and growth failure in primordial dwarfism.

    • Jessica J. R. Hudson
    • Rowin Appanah
    • Ulrich Rass
    ArticleOpen Access
  • A risk-based, spatially explicit analysis of carbon storage in sedimentary basins establishes a prudent planetary limit of around 1,460 Gt of geological carbon storage, which requires making explicit decisions on priorities for storage use.

    • Matthew J. Gidden
    • Siddharth Joshi
    • Joeri Rogelj
    ArticleOpen Access
  • The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in mice.

    • Leenoy Meshulam
    • Dora Angelaki
    • Ilana B. Witten
    ArticleOpen Access
Donald Trump stands at a podium speaking into a microphone, holding up some paperwork.

How Trump 2.0 is reshaping science

Since US President Donald Trump took office in January 2025, his team has made major changes to the federal government that have disrupted research and research institutions in the United States and beyond.
Collection

Advertisement

Nature Careers

Science jobs

Advertisement