Nature

A computer render illustration of hallucinated ring proteins.

Scientists are using AI to dream up revolutionary new proteins

Huge advances in artificial intelligence mean researchers can design completely original molecules in seconds instead of months.

NASA’s Mars rover makes ‘fantastic’ find in search for past life

Perseverance has collected four rock samples from an ancient river delta where organisms might have thrived.

Alexandra Witze
News 16 Sept 2022
COVID deaths: more than 10 million children lost a parent or carer

The consequences of losing a parent can be profound, but the right support can reduce the impact.

Jude Coleman
News 16 Sept 2022
A year-round satellite sea-ice thickness record from CryoSat-2

Deep learning and numerical simulations of CryoSat-2 radar altimeter data are used to generate a pan-Arctic sea-ice thickness dataset for the Arctic melt period.

Jack C. Landy
Geoffrey J. Dawson
Yevgeny Aksenov
Article 14 Sept 2022
Daily briefing: The most climate-friendly seafood

Farmed shellfish is nutritious and low-carbon — but wild-caught crustaceans have a carbon footprint right up there with beef. Plus, what scientists are learning about severe monkeypox and a five-year campaign breaks science’s citation paywall.

Flora Graham
Nature Briefing 14 Sept 2022
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Current Issue 15 Sept 2022

News & Comment

Flight emissions, which fish to eat — the week in infographics

Nature highlights three key graphics from the week in science and research.

News 20 Sept 2022
The case for lotteries as a tiebreaker of quality in research funding

Editorial 20 Sept 2022
Sea turtles swim easier as poaching declines
Freda Kreier
News 20 Sept 2022
World’s largest fusion experiment ITER appoints new chief
Elizabeth Gibney
News 16 Sept 2022
A cleaner future for flight — aviation needs a radical redesign
Steffen Kallbekken
David G. Victor
Comment 16 Sept 2022
How fast fashion can cut its staggering environmental impact

Editorial 16 Sept 2022
NASA’s Mars rover makes ‘fantastic’ find in search for past life
Alexandra Witze
News 16 Sept 2022

Latest Reviews & Analysis

- From the archive: city smoke, and Pasteur’s beer-making invention
  
  Snippets from Nature’s past.
  
  News & Views 20 Sept 2022
- Stressful start causes chromosome errors in human embryos
  
  Analysis of early human embryos reveals that DNA duplication after fertilization is highly inefficient. This causes DNA damage, chromosome breaks and abnormal numbers of chromosomes, impairing embryo development.
  Tommaso Cavazza
  Melina Schuh
  
  News & Views 16 Sept 2022
- A stable alternative to an explosive synthetic reaction
  
  The ozonolysis reaction is a classic of organic synthesis, but involves the formation of potentially explosive reaction intermediates. A modern, safer spin on this process makes use of previously overlooked chemistry.
  Vignesh Palani
  Alison Wendlandt
  
  News & Views 16 Sept 2022
- Two-drug trick to target the brain blocks toxicity in the body
  
  When combined, two drugs alter the activity of a protein complex called target of rapamycin complex 1 such that it is inhibited in the brain but not the body, enabling the treatment of brain tumours in mice without systemic toxicity.
  Matthias P. Wymann
  Chiara Borsari
  
  News & Views 14 Sept 2022
- Fluorescence limitations overcome by engineering light–matter interactions
  
  The process by which pixels fluoresce in electronic displays uses energy highly inefficiently. The identification of fluorescent molecules with an unusual order of excited states opens up a fresh approach to tackling this issue.
  Juan-Carlos Sancho-García
  
  News & Views 14 Sept 2022
- A glimpse into the deepest parts of the Fagradalsfjall volcanic system
  
  Research Briefing 14 Sept 2022
- Simple solids can mimic complex electronic states
  Mandar M. Deshmukh
  
  News & Views 14 Sept 2022
- Life brought to artificial cells
  N. Amy Yewdall
  
  News & Views 14 Sept 2022
- From the archive: how laughter evolved, and mysterious sea creatures
  
  News & Views 13 Sept 2022

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Latest Research articles

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

Nils Frank
Jeremy Nugent
Edward A. Anderson
Article 15 Sept 2022
Structures of α-synuclein filaments from human brains with Lewy pathology

Yang Yang
Yang Shi
Michel Goedert
Article 15 Sept 2022
Control of cell state transitions

An approach called cell state transition assessment and regulation uses diverse multiomics data to map cell states, model their transitions, and understand the signalling networks that control them.

Oleksii S. Rukhlenko
Melinda Halasz
Boris N. Kholodenko
Article 14 Sept 2022
A universal coupling mechanism of respiratory complex I

Cryo-electron microscopy studies of Escherichia coli complex I suggest a conserved mechanism of coupled proton transfers and electrostatic interactions that result in proton ejection from the complex exclusively at the distal NuoL subunit.

Vladyslav Kravchuk
Olga Petrova
Leonid Sazanov
Article 14 Sept 2022
Brain-restricted mTOR inhibition with binary pharmacology

The combination of the brain-permeable mTOR inhibitor RapaLink-1 and the brain-impermeable FKBP12 ligand RapaBlock enable brain-specific inhibition of mTOR.

Ziyang Zhang
Qiwen Fan
Kevan M. Shokat
Article Open Access 14 Sept 2022