A couple-close approach used to build semisaturated ring systems from dual radical precursors allows sampling of regions of underexplored chemical space, leading to an annulation that can be used for late-stage functionalization of pharmaceutical scaffolds.

The hippocampal dentate spike, an understudied population event that frequently occurs between sharp-wave ripples, may underlie a mechanism re-engaging the brain with the external world during synchronous population events, and support memory during non-locomotor behaviour.

We integrate approximately one million aerial site measurements into regional emissions inventories for six regions in the USA, finding methane emission intensities that vary by more than a factor of ten.

Z-DNA anchors the AIRE-mediated transcriptional program by enhancing the generation of double-stranded breaks and promoter poising.

A study describes an approach using designed building blocks that are far more regular in geometry than natural proteins to construct modular multicomponent protein assemblies.