Collection |

Delivery of drugs and biologics

Efficient approaches that overcome the physicochemical and biological barriers to getting therapeutics into the right tissues and cells are critical to therapy development.

This Collection is updated when relevant new content is published. Content appears in reverse chronological order. See all Collections from Nature Biomedical Engineering.

Research

The combination of tumour-infarction therapy and chemotherapy, delivered via nanoparticles decorated with a tumour-homing peptide and encapsulating thrombin and doxorubicin, outperforms the corresponding monotherapies in tumour-bearing mice and rabbits.

Article | | Nature Biomedical Engineering

Conjugation of exendin-4 — a drug to treat type 2 diabetes — with a poly(ethylene glycol) (PEG)-based brush polymer reduces the conjugate's reactivity towards anti-PEG antibodies and leads to lower blood glucose levels in mice for up to 5 days after a single injection.

Article | | Nature Biomedical Engineering

News & Comment

The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.

News & Views | | Nature Biomedical Engineering

Translational cancer nanomedicine needs to increasingly exploit newly discovered tumour-targeting strategies as well as the further optimization of proven means to selectively increase the concentration of cytotoxic drugs in solid tumours.

Editorial | | Nature Biomedical Engineering

Drug-loaded nanoparticles that specifically bind to phages infecting cancer-promoting bacteria found in colonic tumours augment the effects of chemotherapy against colorectal cancer in mice.

News & Views | | Nature Biomedical Engineering

Two drug-loaded nanoparticle formulations that preferentially accumulate within tumour-associated macrophages induce macrophage repolarization to a tumoricidal state that leads to potent antitumour activity in multiple murine models of cancer.

News & Views | | Nature Biomedical Engineering

Polymer-coated gold nanoparticles carrying the CRISPR components for knocking out, in the striatum of adult mice with fragile X syndrome, a gene implied in the syndrome’s pathophysiology rescue the mice from the exaggerated repetitive behaviours characteristic of the syndrome’s phenotype.

News & Views | | Nature Biomedical Engineering

Exosomes expressing CD47 and loaded with interfering RNA dodge phagocytosis and accumulate in pancreatic tumours to silence the expression of the oncogene Kras in mice, with remarkable therapeutic efficacy.

News & Views | | Nature Biomedical Engineering