Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

STEM CELL DELIVERY

Platelet vesicles help cardiac stem cells engraft

Grafting platelet-derived nanovesicles onto the surface of cardiosphere-derived cardiac stem cells enables the cells to better engraft in infarcted tissue following systemic injection in rats and pigs.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The engraftment of cardiosphere-derived cardiac stem cells (CSCs) can be improved by combining them with platelet-derived nanovesicles (PNVs).

References

  1. Fisher, S.  A. et al. Clin. Pharmacol. Ther. 100, 88–101 (2016).

    Article  CAS  PubMed  Google Scholar 

  2. Contreras, A. et al. Basic Res. Cardiol. 112, 3 (2017).

    Article  PubMed  Google Scholar 

  3. Wollert, K.  C. et al. Eur. Heart J. 38, 2936–2943 (2017).

    Article  PubMed  Google Scholar 

  4. Puymirat, E. et al. Circulation 136, 1908–1919 (2017).

    Article  PubMed  Google Scholar 

  5. Hofmann, M. et al. Circulation 111, 2198–2202 (2005).

  6. Tang, J. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-017-0182-x (2018).

    Google Scholar 

  7. Makkar, R.  R. et al. Lancet 379, 895–904 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Lipinski, M.  J. et al. Cardiovasc. Revasc. Med. 17, 106–112 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lane, R.  E. et al. Sci. Rep. 5, 7639 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Guo, Y. et al. Basic Res. Cardiol. 112, 18 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Jain, V. et al. Curr. Drug Deliv. 12, 177–191 (2015).

    Article  CAS  PubMed  Google Scholar 

  12. Liu, M. et al. Biomaterials 35, 3697–3707 (2014).

    Article  CAS  PubMed  Google Scholar 

  13. Yu, J. et al. J. Cell Mol. Med. 19, 1483–1491 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Kean, T.  J. et al. J. Drug Target. 20, 23–32 (2012).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philippe Menasché.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Menasché, P. Platelet vesicles help cardiac stem cells engraft. Nat Biomed Eng 2, 4–5 (2018). https://doi.org/10.1038/s41551-017-0185-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-017-0185-7

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing