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Wireless miniaturized implantable temperature sensors enable real-time monitoring of the progression of inflammatory bowel diseases, as shown in a mouse model of Crohn’s-disease-like ileitis.
The development of dental calculi involves bacteria in local mature biofilms converting the DNA in neutrophil extracellular traps from being degradable by the enzyme DNase I to being degradation resistant.
Mouse B cells can be reprogrammed via Cas12a to express human antibodies that when affinity-matured in recipient mice generate broader and more potent antibody variants.
Hydronium ions bordering cancer cells are highly concentrated into a small extracellular region, and in tumour tissue such severely polarized acidity correlates with the expression of monocarboxylate transporters and with the exclusion of cytotoxic T cells.
The intravenous injection of neutrophils bearing discoidal polymer microscale ‘patches’ on their surfaces reduces tumour burden in mice owing to the patch-induced polarization of the neutrophils towards an antitumour phenotype.
A machine-learning model trained on interactions between oral drugs and intestinal drug transporters obtained by modulating their expression in intact porcine tissue can be used to predict drug–transporter and drug–drug interactions.
The off-tumour toxicity of a supramolecular bispecific T cell engager can be halted by disengaging T cells from the tumour cells via the disassembly of the supramolecular aggregate through the infusion of the small-molecule drug amantadine.
The delivery of mRNAs into neurons at inflammatory sites in vivo can be enhanced by engineering leucocytes to produce extracellular vesicles incorporating mRNA-packaging retrovirus-like capsids.
The inference process of medical-image classifiers can be audited by levering the expertise of physicians to identify medically meaningful features in ‘counterfactual’ images produced via generative AI.
Patient-derived intestinal organoids and tumouroids supplemented with immune cells can be used to predict and study the on-target off-tumour toxicities of T-cell-engaging bispecific antibodies and to capture inter-patient variabilities in the responses to the antibodies.
Closed-loop spinal cord stimulation with commercially available electrodes can evoke sensations in the missing foot of three individuals with transtibial amputation, providing them with improved balance and gait and reducing phantom limb pain.
The targeted integration of large DNA payloads into primary human T cells can be efficiently achieved non-virally by leveraging Cas9-based editing and the DNA-repair pathway homology-mediated end joining.
Nonlinear latent factors and latent structures in the activity of neural populations can be computationally modelled to enable flexible inference and to better predict neural activity and behaviour.
The growth of aortic aneurysms can be predicted via a dimensionless physiomarker, derived from first principles and calculated from data acquired via 4D flow magnetic resonance imaging, that describes a transition from stable blood flow to unstable aortic fluttering.
The composition of lipid nanoparticles for the delivery of tumour-antigen-encoding mRNA can be optimized via a screening method to enhance antitumour activity via the modulation of the immune activity of helper T cells.
Linear mathematical models derived from measurements of local field potentials and of whole-brain blood-oxygen-level-dependent neural activity predict resting-state neural dynamics at least as accurately as nonlinear models.
Antigen-restricted mature T cells can be generated from pluripotent stem cells edited to lack endogenous T cell receptors and class I major histocompatibility complexes by introducing the T cell selection components into the stromal microenvironment.
A wide-field fluorescence microscope leveraging a spinning disc and high-speed cameras enables the recording of neural activities and neutrophil trajectories at micrometric resolution on curved cortical surfaces in live mice.
Optimized base editors targeting the exon-7 mutation in SMN2 restore expression of the survival motor neuron (SMN) protein to normal levels, as shown in mice with spinal muscular atrophy and in fibroblasts from patients with this genetic disease.
A subcutaneous injection of a glucose-responsive formulation of insulin that does not trigger the formation of a fibrous capsule leads to week-long normoglycaemia in mice and minipigs with type 1 diabetes.