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DRUG DELIVERY

Packaging RNA drugs into extracellular vesicles

Nature Biomedical Engineering volume 4, pages 6–8 (2020)Cite this article

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The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.

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Fig. 1: Sorting of miRNA and siRNA into extracellular vesicles.
Fig. 2: Efficiency of in vivo knockdown by siRNA loaded into EVs via the pre-miRNA-451 backbone.

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Acknowledgements

The authors are supported by the grants CCA2016-5-35 (to D.M.P. and M.A.J.vE.) and CCA2018-5-47 (to S.R.B.), provided by the Stichting Cancer Center Amsterdam.

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Authors and Affiliations

  1. Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

    Monique A. J. van Eijndhoven, S. Rubina Baglio & D. Michiel Pegtel

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  1. Monique A. J. van Eijndhoven
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  2. S. Rubina Baglio
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  3. D. Michiel Pegtel
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Correspondence to D. Michiel Pegtel.

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Competing interests

D.M.P. is a co-founder and the chief scientific officer of exBiome BV, and an advisor for Takeda.

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van Eijndhoven, M.A.J., Baglio, S.R. & Pegtel, D.M. Packaging RNA drugs into extracellular vesicles. Nat Biomed Eng 4, 6–8 (2020). https://doi.org/10.1038/s41551-019-0514-0

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