Collection |

Delivery of drugs and biologics

Efficient approaches that overcome the physicochemical and biological barriers to getting therapeutics into the right tissues and cells are critical to therapy development.

This Collection is updated when relevant new content is published. Content appears in reverse chronological order. See all Collections from Nature Biomedical Engineering.

Research

  • Nature Biomedical Engineering | Article

    A mechanical injector that targets tissue by sensing the loss-of-resistance on encountering softer tissue or a cavity can reliably and precisely deliver liquids to the suprachoroidal space, and to other injection-accessible target sites in the body.

    • Girish D. Chitnis
    • , Mohan K. S. Verma
    • , Julien Lamazouade
    • , Miguel Gonzalez-Andrades
    • , Kisuk Yang
    • , Ali Dergham
    • , Peter Anthony Jones
    • , Benjamin E. Mead
    • , Andrea Cruzat
    • , Zhixiang Tong
    • , Keir Martyn
    • , Aniruddh Solanki
    • , Natalie Landon-Brace
    •  &  Jeffrey M. Karp
  • Nature Biomedical Engineering | Article

    DNA origami nanostructures with different shapes can accumulate preferentially in the kidney, with some being renal-protective, as shown in healthy mice and in a mouse model of acute kidney injury.

    • Dawei Jiang
    • , Zhilei Ge
    • , Hyung-Jun Im
    • , Christopher G. England
    • , Dalong Ni
    • , Junjun Hou
    • , Luhao Zhang
    • , Christopher J. Kutyreff
    • , Yongjun Yan
    • , Yan Liu
    • , Steve Y. Cho
    • , Jonathan W. Engle
    • , Jiye Shi
    • , Peng Huang
    • , Chunhai Fan
    • , Hao Yan
    •  &  Weibo Cai
  • Nature Biomedical Engineering | Article

    The systemic administration of haematopoietic stem cells conjugated to anti-PD-1-decorated platelets in leukaemic mice promotes the delivery of the checkpoint inhibitor to the bone marrow and suppresses the growth and recurrence of leukaemia.

    • Quanyin Hu
    • , Wujin Sun
    • , Jinqiang Wang
    • , Huitong Ruan
    • , Xudong Zhang
    • , Yanqi Ye
    • , Song Shen
    • , Chao Wang
    • , Weiyue Lu
    • , Ke Cheng
    • , Gianpietro Dotti
    • , Joshua F. Zeidner
    • , Jun Wang
    •  &  Zhen Gu
  • Nature Biomedical Engineering | Article

    The reintroduction of PTEN mRNA into PTEN-null prostate cancer cells via encapsulation in polymer–lipid nanoparticles delivered systemically leads to significant inhibition of tumour growth in mouse models of prostate cancer.

    • Mohammad Ariful Islam
    • , Yingjie Xu
    • , Wei Tao
    • , Jessalyn M. Ubellacker
    • , Michael Lim
    • , Daniel Aum
    • , Gha Young Lee
    • , Kun Zhou
    • , Harshal Zope
    • , Mikyung Yu
    • , Wuji Cao
    • , James Trevor Oswald
    • , Meshkat Dinarvand
    • , Morteza Mahmoudi
    • , Robert Langer
    • , Philip W. Kantoff
    • , Omid C. Farokhzad
    • , Bruce R. Zetter
    •  &  Jinjun Shi
  • Nature Biomedical Engineering | Article

    Macromolecular telmisartan prodrugs optimized for preferential release in fibrotic liver tissue reduce liver fibrosis in mouse models, and are retained and well tolerated in the liver tissue of rats and dogs.

    • Matthew R. Golder
    • , Jenny Liu
    • , Jannik N. Andersen
    • , Michail V. Shipitsin
    • , Farrukh Vohidov
    • , Hung V.-T. Nguyen
    • , Deborah C. Ehrlich
    • , Sung Jin Huh
    • , Bhavatarini Vangamudi
    • , Kyriakos D. Economides
    • , Allison M. Neenan
    • , James C. Ackley
    • , Joelle Baddour
    • , Sattanathan Paramasivan
    • , Samantha W. Brady
    • , Eric J. Held
    • , Lawrence A. Reiter
    • , Jennifer K. Saucier-Sawyer
    • , Paul W. Kopesky
    • , Donald E. Chickering
    • , Peter Blume-Jensen
    •  &  Jeremiah A. Johnson

News & Comment

  • Nature Biomedical Engineering | News & Views

    A patch that deposits an array of microneedle tips under the top layer of the skin enables weeks-long delivery of a contraceptive in rats.

    • Ryan F. Donnelly
    •  &  Eneko Larraňeta
  • Nature Biomedical Engineering | News & Views

    Widespread editing of the mutated DMD gene by CRISPR–Cas9, systemically delivered via an adeno-associated virus, restores dystrophin expression in a canine model of Duchenne muscular dystrophy.

    • Dongsheng Duan
  • Nature Biomedical Engineering | News & Views

    The coupling of blood platelets bearing anti-programmed cell death protein 1 antibodies to haematopoietic stem cells enables delivery of checkpoint-blockade therapy to bone marrow to promote T-cell-mediated control of leukaemia in mice.

    • Martina Seiffert
  • Nature Biomedical Engineering | News & Views

    Two drug-loaded nanoparticle formulations that preferentially accumulate within tumour-associated macrophages induce macrophage repolarization to a tumoricidal state that leads to potent antitumour activity in multiple murine models of cancer.

    • Heather H. Gustafson
    •  &  Suzie H. Pun
  • Nature Biomedical Engineering | News & Views

    Polymer-coated gold nanoparticles carrying the CRISPR components for knocking out, in the striatum of adult mice with fragile X syndrome, a gene implied in the syndrome’s pathophysiology rescue the mice from the exaggerated repetitive behaviours characteristic of the syndrome’s phenotype.

    • Yamin Li
    • , Zachary Glass
    •  &  Qiaobing Xu
  • Nature Biomedical Engineering | Editorial

    When designing translationally relevant delivery strategies to overcome the physicochemical and biological barriers to getting therapeutics into the right tissues and cells, building on tried-and-tested concepts often pays off.