Molecular biology

Definition

Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules – such as nucleic acids and proteins – that carry out the biological processes essential for the cell’s functions and maintenance.

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Latest Research and Reviews

  • Research |

    Cryo-electron microscopy analysis of yeast Rad26 bound to RNA polymerase II provides insight into the initiation of the transcription-coupled DNA repair mechanism in eukaryotes.

    • Jun Xu
    • , Indrajit Lahiri
    • , Wei Wang
    • , Adam Wier
    • , Michael A. Cianfrocco
    • , Jenny Chong
    • , Alissa A. Hare
    • , Peter B. Dervan
    • , Frank DiMaio
    • , Andres E. Leschziner
    •  & Dong Wang
  • Research |

    BRCA1, but not BRCA2, suppresses the formation of tandem duplications at stalled replication forks in primary mammalian cells.

    • Nicholas A. Willis
    • , Richard L. Frock
    • , Francesca Menghi
    • , Erin E. Duffey
    • , Arvind Panday
    • , Virginia Camacho
    • , E. Paul Hasty
    • , Edison T. Liu
    • , Frederick W. Alt
    •  & Ralph Scully
  • Reviews |

    Structures in 5′ untranslated regions of eukaryotic mRNAs contribute to gene regulation by controlling cap-dependent and cap-independent translation initiation through diverse mechanisms. New structure probing technologies coupled with techniques such as compensatory mutagenesis will likely identify new structured RNA elements and help elucidate their function.

    • Kathrin Leppek
    • , Rhiju Das
    •  & Maria Barna
  • Research | | open

    Target of rapamycin (TOR) kinase operates within two distinct multiprotein complexes named TORC1 and TORC2. Here the authors report a cryo-EM structure of TORC2, establish its subunit organization, providing a rationale for TORC2’s rapamycin insensitivity and the mutually exclusive inclusion of Avo3/Rictor or Raptor within their respective TOR complex.

    • Manikandan Karuppasamy
    • , Beata Kusmider
    • , Taiana M. Oliveira
    • , Christl Gaubitz
    • , Manoel Prouteau
    • , Robbie Loewith
    •  & Christiane Schaffitzel
  • Research | | open

    Cas9 and Cpf1 have both been adapted for genome engineering, editing and gene expression regulation. Here the authors design a fusion guide RNA that can interact with both proteins for multiple and orthogonal genome manipulation.

    • Jiyeon Kweon
    • , An-Hee Jang
    • , Da-Eun Kim
    • , Jin Wook Yang
    • , Mijung Yoon
    • , Ha Rim Shin
    • , Jin-Soo Kim
    •  & Yongsub Kim

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