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Phosphorothioate (PT) DNA modifications in E. coli and Salmonella are turned over to maintain bacterial fitness through decreased susceptibility to genomic instability caused by hypochlorous-acid-mediated PT oxidation.
A novel combination of magnetic tweezers and single-molecule TIRF microscopy reveals that topoisomerase IA makes multiple attempts to engage DNA before successfully catalyzing strand passage and DNA relaxation.
Recent studies have identified the existence of modified cytosine bases in DNA that result from ten eleven translocation (Tet)-mediated oxidation of 5-methylcytosine. The demonstration that Tet oxidizes thymine to 5-hydroxymethyluracil has implications for our current view of DNA metabolism.