Chromatin

Definition

Chromatin is a flexibly joined chain of nucleosomes that exists inside the nucleus of eukaryotic cells and has been described as a 'bead on a string'. Chromatin organization strengthens DNA for mechanically stressful processes like mitosis, helps protect DNA from damage and is important in the control of gene expression and DNA replication.

Latest Research and Reviews

  • Research | | open

    Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.

    • Alessandra Ferrari
    • , Raffaella Longo
    • , Erika Fiorino
    • , Rui Silva
    • , Nico Mitro
    • , Gaia Cermenati
    • , Federica Gilardi
    • , Béatrice Desvergne
    • , Annapaola Andolfo
    • , Cinzia Magagnotti
    • , Donatella Caruso
    • , Emma De Fabiani
    • , Scott W. Hiebert
    •  & Maurizio Crestani
  • Research |

    How glutamine metabolism orchestrates macrophage activation is unclear. Ho and colleagues show glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming.

    • Pu-Ste Liu
    • , Haiping Wang
    • , Xiaoyun Li
    • , Tung Chao
    • , Tony Teav
    • , Stefan Christen
    • , Giusy Di Conza
    • , Wan-Chen Cheng
    • , Chih-Hung Chou
    • , Magdalena Vavakova
    • , Charlotte Muret
    • , Koen Debackere
    • , Massimiliano Mazzone
    • , Hsien-Da Huang
    • , Sarah-Maria Fendt
    • , Julijana Ivanisevic
    •  & Ping-Chih Ho
  • Research | | open

    Chromatin neighbourhoods, formed by CTCF, have been proposed to isolate enhancers and their target genes from other regulatory elements. Here, the authors provide evidence that while CTCF binding does regulates mammary-specific super-enhancers, CTCF sites are relatively porous borders.

    • M. Willi
    • , K. H. Yoo
    • , F. Reinisch
    • , T. M. Kuhns
    • , H. K. Lee
    • , C. Wang
    •  & L. Hennighausen
  • Research |

    A low-input Hi-C method is used to show that chromatin organization is markedly relaxed in pre-implantation mouse embryos after fertilization and that the subsequent maturation of 3D chromatin architecture is surprisingly slow.

    • Zhenhai Du
    • , Hui Zheng
    • , Bo Huang
    • , Rui Ma
    • , Jingyi Wu
    • , Xianglin Zhang
    • , Jing He
    • , Yunlong Xiang
    • , Qiujun Wang
    • , Yuanyuan Li
    • , Jing Ma
    • , Xu Zhang
    • , Ke Zhang
    • , Yang Wang
    • , Michael Q. Zhang
    • , Juntao Gao
    • , Jesse R. Dixon
    • , Xiaowo Wang
    • , Jianyang Zeng
    •  & Wei Xie
    Nature 547, 232–235
  • Research | | open

    BRG1 and BRM are central components of the BAF (mSWI/SNF) chromatin remodelling complex, which is critical for regulation of chromatin structure. Here, the authors provide evidence that both the BRG1 and hBRM bromodomains have DNA-binding activity and bind to both DNA and H3K14ac simultaneously.

    • Emma A. Morrison
    • , Julio C. Sanchez
    • , Jehnna L. Ronan
    • , Daniel P. Farrell
    • , Katayoun Varzavand
    • , Jenna K. Johnson
    • , Brian X. Gu
    • , Gerald R. Crabtree
    •  & Catherine A. Musselman
  • Research | | open

    Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and promoter long-range interactions.

    • Romina Petersen
    • , John J. Lambourne
    • , Biola M. Javierre
    • , Luigi Grassi
    • , Roman Kreuzhuber
    • , Dace Ruklisa
    • , Isabel M. Rosa
    • , Ana R. Tomé
    • , Heather Elding
    • , Johanna P. van Geffen
    • , Tao Jiang
    • , Samantha Farrow
    • , Jonathan Cairns
    • , Abeer M. Al-Subaie
    • , Sofie Ashford
    • , Antony Attwood
    • , Joana Batista
    • , Heleen Bouman
    • , Frances Burden
    • , Fizzah A. Choudry
    • , Laura Clarke
    • , Paul Flicek
    • , Stephen F. Garner
    • , Matthias Haimel
    • , Carly Kempster
    • , Vasileios Ladopoulos
    • , An-Sofie Lenaerts
    • , Paulina M. Materek
    • , Harriet McKinney
    • , Stuart Meacham
    • , Daniel Mead
    • , Magdolna Nagy
    • , Christopher J. Penkett
    • , Augusto Rendon
    • , Denis Seyres
    • , Benjamin Sun
    • , Salih Tuna
    • , Marie-Elise van der Weide
    • , Steven W. Wingett
    • , Joost H. Martens
    • , Oliver Stegle
    • , Sylvia Richardson
    • , Ludovic Vallier
    • , David J. Roberts
    • , Kathleen Freson
    • , Lorenz Wernisch
    • , Hendrik G. Stunnenberg
    • , John Danesh
    • , Peter Fraser
    • , Nicole Soranzo
    • , Adam S. Butterworth
    • , Johan W. Heemskerk
    • , Ernest Turro
    • , Mikhail Spivakov
    • , Willem H. Ouwehand
    • , William J. Astle
    • , Kate Downes
    • , Myrto Kostadima
    •  & Mattia Frontini

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