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Transposition is the process by which a DNA segment moves from a donor to a recipient DNA molecule. It occurs by cutting both strands of the donor and target DNA duplexes, followed by covalently joining the ends of the mobile segment to those of the target site.
Guanine-rich sequences with a tendency to form G4 structures are a hallmark of hominoid-specific L1 retrotransposons, and their stabilization increases L1 mobility, thus potentially affecting genome evolution.
The Piwi-interacting RNA (piRNA) pathway is known to suppress transposable elements in gonadal tissues. Here the authors provide evidence for a functional piRNA pathway in the somatic cells of the Drosophila fat body with roles in metabolism, immunological function and overall health.