Collection

Cancer at Nature Research

The Nature Research editors who handle cancer primary research, methods, protocols and reviews bring you the latest articles, covering all aspects from disease mechanisms to therapeutic approaches. Collected here you will also find specially curated content, such as collections, focus issues and animations, all ready to be used in presentations and educational materials. You can also find out about the editors handling cancer contents, and the journals at Nature Research that publish articles on this topic and how to submit to them.

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Research Articles

  • Nature Communications | Article | open

    Resistance to BRAFV600E inhibitors often occurs in melanoma patients. Here, the authors describe a potential mechanism of acquired drug resistance mediated by tumor-associated B cells-derived IGF-1.

    • Rajasekharan Somasundaram
    • , Gao Zhang
    • , Mizuho Fukunaga-Kalabis
    • , Michela Perego
    • , Clemens Krepler
    • , Xiaowei Xu
    • , Christine Wagner
    • , Denitsa Hristova
    • , Jie Zhang
    • , Tian Tian
    • , Zhi Wei
    • , Qin Liu
    • , Kanika Garg
    • , Johannes Griss
    • , Rufus Hards
    • , Margarita Maurer
    • , Christine Hafner
    • , Marius Mayerhöfer
    • , Georgios Karanikas
    • , Ahmad Jalili
    • , Verena Bauer-Pohl
    • , Felix Weihsengruber
    • , Klemens Rappersberger
    • , Josef Koller
    • , Roland Lang
    • , Courtney Hudgens
    • , Guo Chen
    • , Michael Tetzlaff
    • , Lawrence Wu
    • , Dennie Tompers Frederick
    • , Richard A. Scolyer
    • , Georgina V. Long
    • , Manashree Damle
    • , Courtney Ellingsworth
    • , Leon Grinman
    • , Harry Choi
    • , Brian J. Gavin
    • , Margaret Dunagin
    • , Arjun Raj
    • , Nathalie Scholler
    • , Laura Gross
    • , Marilda Beqiri
    • , Keiryn Bennett
    • , Ian Watson
    • , Helmut Schaider
    • , Michael A. Davies
    • , Jennifer Wargo
    • , Brian J. Czerniecki
    • , Lynn Schuchter
    • , Dorothee Herlyn
    • , Keith Flaherty
    • , Meenhard Herlyn
    •  &  Stephan N. Wagner
  • Nature Communications | Article | open

    The clinical management of metastatic melanoma requires predictors of the response to checkpoint blockade. Here, the authors use immunological assays to identify potential prognostic/predictive biomarkers in circulating blood cells and in tumor-infiltrating lymphocytes from patients with resected stage III melanoma.

    • N. Jacquelot
    • , M. P. Roberti
    • , D. P. Enot
    • , S. Rusakiewicz
    • , N. Ternès
    • , S. Jegou
    • , D. M. Woods
    • , A. L. Sodré
    • , M. Hansen
    • , Y. Meirow
    • , M. Sade-Feldman
    • , A. Burra
    • , S. S. Kwek
    • , C. Flament
    • , M. Messaoudene
    • , C. P. M. Duong
    • , L. Chen
    • , B. S. Kwon
    • , A. C. Anderson
    • , V. K. Kuchroo
    • , B. Weide
    • , F. Aubin
    • , C. Borg
    • , S. Dalle
    • , O. Beatrix
    • , M. Ayyoub
    • , B. Balme
    • , G. Tomasic
    • , A. M. Giacomo
    • , M. Maio
    • , D. Schadendorf
    • , I. Melero
    • , B. Dréno
    • , A. Khammari
    • , R. Dummer
    • , M. Levesque
    • , Y. Koguchi
    • , L. Fong
    • , M. Lotem
    • , M. Baniyash
    • , H. Schmidt
    • , I. M. Svane
    • , G. Kroemer
    • , A. Marabelle
    • , S. Michiels
    • , A. Cavalcanti
    • , M. J. Smyth
    • , J. S. Weber
    • , A. M. Eggermont
    •  &  L. Zitvogel
  • Nature Communications | Article | open

    MEK inhibition in breast cancer is associated with increased tumour infiltrating lymphocytes (TILs), however, MAPK activity is required for T cells function. Here the authors show that TILs activity following MEK inhibition can be enhanced by agonist immunotherapy resulting in synergic therapeutic effects.

    • Sathana Dushyanthen
    • , Zhi Ling Teo
    • , Franco Caramia
    • , Peter Savas
    • , Christopher P. Mintoff
    • , Balaji Virassamy
    • , Melissa A. Henderson
    • , Stephen J. Luen
    • , Mariam Mansour
    • , Michael H. Kershaw
    • , Joseph A. Trapani
    • , Paul J. Neeson
    • , Roberto Salgado
    • , Grant A. McArthur
    • , Justin M. Balko
    • , Paul A. Beavis
    • , Phillip K. Darcy
    •  &  Sherene Loi
  • Nature Communications | Article | open

    Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor induction of cachexia.

    • Guohua Zhang
    • , Zhelong Liu
    • , Hui Ding
    • , Yong Zhou
    • , Hoang Anh Doan
    • , Ka Wai Thomas Sin
    • , Zhiren J. Zhu
    • , Rene Flores
    • , Yefei Wen
    • , Xing Gong
    • , Qingyun Liu
    •  &  Yi-Ping Li
  • Nature Communications | Article | open

    Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce myeloid-derived suppressor cells and support tumour growth.

    • Sara Trabanelli
    • , Mathieu F. Chevalier
    • , Amaia Martinez-Usatorre
    • , Alejandra Gomez-Cadena
    • , Bérengère Salomé
    • , Mariangela Lecciso
    • , Valentina Salvestrini
    • , Grégory Verdeil
    • , Julien Racle
    • , Cristina Papayannidis
    • , Hideaki Morita
    • , Irene Pizzitola
    • , Camille Grandclément
    • , Perrine Bohner
    • , Elena Bruni
    • , Mukul Girotra
    • , Rani Pallavi
    • , Paolo Falvo
    • , Elisabeth Oppliger Leibundgut
    • , Gabriela M. Baerlocher
    • , Carmelo Carlo-Stella
    • , Daniela Taurino
    • , Armando Santoro
    • , Orietta Spinelli
    • , Alessandro Rambaldi
    • , Emanuela Giarin
    • , Giuseppe Basso
    • , Cristina Tresoldi
    • , Fabio Ciceri
    • , David Gfeller
    • , Cezmi A. Akdis
    • , Luca Mazzarella
    • , Saverio Minucci
    • , Pier Giuseppe Pelicci
    • , Emanuela Marcenaro
    • , Andrew N. J. McKenzie
    • , Dominique Vanhecke
    • , George Coukos
    • , Domenico Mavilio
    • , Antonio Curti
    • , Laurent Derré
    •  &  Camilla Jandus
  • Nature Medicine | Letter

    The N6-methyladenosine (m6A) modification in mRNAs, generated by the enzyme METTL3, controls normal human hematopoietic stem/progenitor cell differentiation and maintains the undifferentiated leukemic phenotype of human acute myeloid leukemia cells.

    • Ly P Vu
    • , Brian F Pickering
    • , Yuanming Cheng
    • , Sara Zaccara
    • , Diu Nguyen
    • , Gerard Minuesa
    • , Timothy Chou
    • , Arthur Chow
    • , Yogesh Saletore
    • , Matthew MacKay
    • , Jessica Schulman
    • , Christopher Famulare
    • , Minal Patel
    • , Virginia M Klimek
    • , Francine E Garrett-Bakelman
    • , Ari Melnick
    • , Martin Carroll
    • , Christopher E Mason
    • , Samie R Jaffrey
    •  &  Michael G Kharas

Reviews

  • Nature Reviews Immunology | Review

    This Review focuses on how the complement cascade can both promote and inhibit antitumour immune responses. The authors discuss the potential of targeting complement components for immunotherapeutic purposes in patients with cancer.

    • Edimara S. Reis
    • , Dimitrios C. Mastellos
    • , Daniel Ricklin
    • , Alberto Mantovani
    •  &  John D. Lambris
  • Nature Reviews Cancer | Consensus Statement | open

    Based on a consensus conference of experts in the evolution and ecology of cancer, this article proposes a framework for classifying tumours that includes four evolutionary and ecological processes: neoplastic cell diversity and changes over time in that diversity, hazards to cell survival and available resources.

    • Carlo C. Maley
    • , Athena Aktipis
    • , Trevor A. Graham
    • , Andrea Sottoriva
    • , Amy M. Boddy
    • , Michalina Janiszewska
    • , Ariosto S. Silva
    • , Marco Gerlinger
    • , Yinyin Yuan
    • , Kenneth J. Pienta
    • , Karen S. Anderson
    • , Robert Gatenby
    • , Charles Swanton
    • , David Posada
    • , Chung-I Wu
    • , Joshua D. Schiffman
    • , E. Shelley Hwang
    • , Kornelia Polyak
    • , Alexander R. A. Anderson
    • , Joel S. Brown
    • , Mel Greaves
    •  &  Darryl Shibata
  • Nature Reviews Cancer | Review

    This Review by Corbet and Feron summarizes recent data showing that tumour acidosis influences cancer metabolism and contributes to cancer progression; it also highlights advances in therapeutic modalities aimed at either inhibiting or exploiting tumour acidification.

    • Cyril Corbet
    •  &  Olivier Feron
  • Nature Reviews Urology | Review

    WNT signalling pathway components are potentially important in prostate tumours, particularly in the development of castration-resistant prostate cancer and in the prostate tumour microenvironment. Here, Murillo-Garzón and Kypta describe our current understanding of WNT signalling in prostate cancer and discuss the potential of drugs that target this pathway.

    • Virginia Murillo-Garzón
    •  &  Robert Kypta
  • Nature Biomedical Engineering | Review Article

    This Review discusses imaging approaches that benefit from the combination of signals and modalities to enhance patient diagnosis and the monitoring of therapy.

    • Kathrin Heinzmann
    • , Lukas M. Carter
    • , Jason S. Lewis
    •  &  Eric O. Aboagye
  • Nature Reviews Urology | Review

    The clinical relevance of variant histology in urinary bladder cancer has been increasing, resulting in new classifications of urothelial cancers by the WHO in 2016 and highlighting the importance of an accurate morphological description of pathological specimens for the therapeutic management of patients with bladder cancer.

    • Marco Moschini
    • , David D'Andrea
    • , Stephan Korn
    • , Yasin Irmak
    • , Francesco Soria
    • , Eva Compérat
    •  &  Shahrokh F. Shariat

News & Commentary

Methods & Protocols

  • Nature Methods | Article

    Informed-Proteomics, a software suite for top-down proteomics analysis, consists of a high-accuracy liquid chromatography–mass spectrometry feature-finding algorithm, an efficient database search tool, and an interactive results viewer.

    • Jungkap Park
    • , Paul D Piehowski
    • , Christopher Wilkins
    • , Mowei Zhou
    • , Joshua Mendoza
    • , Grant M Fujimoto
    • , Bryson C Gibbons
    • , Jared B Shaw
    • , Yufeng Shen
    • , Anil K Shukla
    • , Ronald J Moore
    • , Tao Liu
    • , Vladislav A Petyuk
    • , Nikola Tolić
    • , Ljiljana Paša-Tolić
    • , Richard D Smith
    • , Samuel H Payne
    •  &  Sangtae Kim
  • Nature Protocols | Protocol

    This protocol describes how to design 3D-printed scaffolds via melt electrospinning writing for bone tissue engineering applications and how to engineer humanized bone for the study of cancer metastasis in vivo.

    • Laure C Martine
    • , Boris M Holzapfel
    • , Jacqui A McGovern
    • , Ferdinand Wagner
    • , Verena M Quent
    • , Parisa Hesami
    • , Felix M Wunner
    • , Cedryck Vaquette
    • , Elena M De-Juan-Pardo
    • , Toby D Brown
    • , Bianca Nowlan
    • , Dan Jing Wu
    • , Cosmo Orlando Hutmacher
    • , Davide Moi
    • , Tatiana Oussenko
    • , Elia Piccinini
    • , Peter W Zandstra
    • , Roberta Mazzieri
    • , Jean-Pierre Lévesque
    • , Paul D Dalton
    • , Anna V Taubenberger
    •  &  Dietmar W Hutmacher