Nature Reviews Molecular Cell Biology
Volume 9, No 9 September 2008
Featured Article
Conserved functions of the pRB and E2F families
Sander van den Heuvel & Nicholas J. Dyson
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2007 ISI Impact Factor 31.921(*Source of Impact Factor data)
Current Issue
Poster
Pluripotent cell isolation for regenerative medicine
Christopher Lengner & Rudolf Jaenisch
Pluripotent cells offer great promise for regenerative medicine. In this Poster, Christopher Lengner and Rudolf Jaenisch compare and contrast the properties of pluripotent embryonic stem cells with those of laboratory-generated pluripotent cells. The Poster is freely available thanks to support from STEMCELL Technologies Inc.
Current Issue
Review
Mammalian Rho GTPases: new insights into their functions from in vivo studies
Sarah J. Heasman & Anne J. Ridley
The roles of Rho GTPases have been extensively studied in several mammalian cell types using different mutants. The availability of knockout mice for several members of the Rho family is now revealing new information about their roles in signalling to the cytoskeleton and in development.
Current Issue
Review
A complex barcode underlies the heterogeneous response of p53 to stress
Fiona Murray-Zmijewski, Elizabeth A. Slee & Xin Lu
The tumour suppressor p53 integrates incoming stress signals to prevent malignant progression by inducing cell responses such as apoptosis and senescence. The specific response, coordinated by p53 post-translational modifications and the availability of p53 cofactors, determines the appropriate cellular fate.
Current Issue
Progress
Endogenous small interfering RNAs in animals
Katsutomo Okamura & Eric C. Lai
An endogenous small interfering RNA (endo-siRNA) pathway had only previously been characterized in worms. The recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in flies and mice raise many questions regarding the biogenesis and function of small regulatory RNAs in animals.
Current Issue
Research Highlights
Cancer biology:
The counting game
Francesca Cesari
Researchers have examined the process of centrosome clustering, providing new leads for therapeutic approaches.
Small RNAs:
Making a big impression on the proteome
Elizabeth Neame
How does microRNA regulation of gene expression affect the proteome?
Advance Online Publication
Perspective
Transcription-
independent functions of MYC: regulation of translation and DNA replication
Michael D. Cole & Victoria H. Cowling
MYC is a potent oncogene that functions as a transcription factor. Extensive research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. But does MYC also have transcription-independent roles?
More Molecular Cell Biology
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Conferences
A calendar of forthcoming meetings and workshops from across the field of molecular and cell biology.
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Nature Milestones series
Collections of key discoveries that have shaped different scientific fields.
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molecular cell biology@nature.com
More articles on molecular cell biology from the Nature Publishing Group.
Noticeboard
Focus on Ageing
This Focus provides a snapshot of lipid biology. The accompanying Poster, which was produced with support from Merck Serono International S.A. provides an overview of the protein–lipid signalling network and how this network can be exploited to attenuate proliferative, inflammatory and metabolic diseases.
Poster on Readout of chromatin marks
This Poster illustrates well-known histone marks and representative examples of histone-binding effector modules, and outlines emerging themes in the molecular recognition of modified histones. It also describes possible modes of multivalent chromatin mark recognition, which are also discussed in the accompanying article by C. David Allis, Dinshaw J. Patel & colleagues.
Focus on Ageing
This Focus highlights the latest advances in our understanding of ageing at the molecular and cellular level, and how this translates to organismal ageing. The accompanying podcast, which was produced with support from Sirtris Pharmaceuticals, features a round-table discussion with experts Lenny Guarente, Cynthia Kenyon and David Sinclair.
Stem cells series
In a Series of specially commissioned articles, Nature Reviews Molecular Cell Biology reports on the current hot and exciting topics in stem-cell research, discusses new technologies and resources to study stem cells and explores controversial issues, such as stem-cell ethics and funding.
Web Focus Collection
Please visit our archive of selected articles from the Nature Publishing Group on key current topics. Web Focuses are updated monthly with relevant Review and Perspective articles from Nature Reviews Molecular Cell Biology.
Journal Citation Reports, Thomson, 2008