Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Bone marrow niches

The enduring neutrophil–stroma dance of multiple myeloma

Nature Immunology (2024)Cite this article

Subjects

Inflammatory memory cues initiated by neutrophils and bone marrow stroma suggest potential therapeutic targets for the treatment of multiple myeloma.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Myeloma cells imprint alterations in bone marrow stroma.

References

  1. de Visser, K. E. & Joyce, J. A. Cancer Cell 41, 374–403 (2023).

    Article  PubMed  Google Scholar 

  2. de Jong, M. M. E. et al. Nat. Immunol. https://doi.org/10.1038/s41590-024-01808-x (2024).

    Article  Google Scholar 

  3. Méndez-Ferrer, S. et al. Nat. Rev. Cancer 20, 285–298 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  4. de Jong, M. M. E. et al. Nat. Immunol. 22, 769–780 (2021).

    Article  PubMed  Google Scholar 

  5. Parrinello, N. et al. Blood 122, 3138–3138 (2013).

    Article  Google Scholar 

  6. Naik, S. & Fuchs, E. Nature 607, 249–255 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Baryawno, N. et al. Cell 177, 1915–1932.e16 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Ballesteros, I. et al. Cell 183, 1282–1297.e18 (2020).

    Article  CAS  PubMed  Google Scholar 

  9. Gong, Z. et al. Sci. Immunol. 8, eadd5204 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Engblom, C. et al. Science 358, eaal5081 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA

    Daniela Cerezo-Wallis

  2. Cardiovascular regeneration program, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain

    Iván Ballesteros

Authors
  1. Daniela Cerezo-Wallis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Iván Ballesteros
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Iván Ballesteros.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cerezo-Wallis, D., Ballesteros, I. The enduring neutrophil–stroma dance of multiple myeloma. Nat Immunol (2024). https://doi.org/10.1038/s41590-024-01810-3

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41590-024-01810-3

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer