Nature Immunology - CURRENT ISSUE : May 2008 - Vol 9 No 5
LATEST HIGHLIGHTS
Article of the Month
The CD3ε proline-rich sequence somehow facilitates T cell signaling. Malissen and colleagues now demonstrate that in CD4+CD8+ thymocytes, this sequence enhances the sensitivity of T cell receptors to weak ligands.
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News & Views by Maltzman & KoretzkyFOCUS
FOCUS ON Natural Killer Cells
FocusNature Immunology presents a series of specially commissioned articles that discuss various aspects of natural killer cell function and biology. Free for 6 months.
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Scalable TCR signaling
Article by HolstWhy the T cell receptor contains ten immunoreceptor tyrosine-based activation motifs (ITAMs) is not well understood. Vignali and colleagues demonstrate that specific numbers of ITAMs are needed for T cell development and function, and to prevent autoimmunity.
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Foxo1 regulates Rag
Article by AminAntigen receptor genes undergo a highly ordered series of recombination steps to generate functional receptors. Amin and Schlissel show that the transcription factor Foxo1 regulates Rag expression in B cells.
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Flt3 and DC homeostasis
Article by WaskowLittle is known about homeostatic regulation of conventional dendritic cells (cDC) in lymphoid organs. Nussenzweig and colleagues demonstrate Flt3 is required for progenitor migration from bone marrow and cDC division in the periphery.
ANNOUNCEMENT
La Fondation IPSEN, Nature Immunology and Nature Cell Biology are pleased to announce an Emergence & Convergence mini-symposium on September 29, 2008, Gleacher Center, Chicago, Illinois, USA. This one-day mini-symposium aims to promote discussion between immunologists and cell biologists studying the molecular mechanisms underlying cell polarization, synapse formation and asymmetric cell division, as well as the influence of these processes on cell-fate determination and function.
Applications are currently being accepted.