Advance online publication

Review

Colonic crypt organization and tumorigenesis

Adam Humphries & Nicholas A. Wright

Recent advances in our understanding of intestinal crypt biology, including how mutations in stem cells become fixed and expand within the epithelium, has led to new theories on the origins of colonic adenomas and cancers.

Advance online publication

Perspective

Paul Ehrlich's magic bullet concept: 100 years of progress

Klaus Strebhardt & Axel Ullrich

One hundred years ago, Paul Ehrlich received the Nobel Prize for Physiology or Medicine. His idea of creating 'magic bullets' for use in the fight against human diseases has inspired generations of scientists to devise powerful molecular cancer therapeutics.

Advance online publication

Perspective

Heavy ion carcinogenesis and human space exploration

Marco Durante & Francis A. Cucinotta

The next generation of space missions will involve much longer exposures of astronauts to space radiation. Predicting what this means for cancer risk is a crucial but difficult task.
(Image courtesy of NASA)

Advance online publication

Perspective

The Mouse Tumor Biology database

Debra M. Krupke, Dale A. Begley, John P. Sundberg, Carol J. Bult & Janan T. Eppig

The Mouse Tumor Biology database seeks to facilitate the researcher's access to the ever increasing amount of data now being published using mouse models of cancer. Why is this database important and how does it relate to similar databases within the cancer research community?

Collections

Stem cells

Stem–cell research has a history of more than 20 years, and every month we are gaining a better understanding of both embryonic and adult stem cells at the molecular level and of how they behave in their biological context. Such progress is of great significance in cell and developmental biology, as is evident in this Nature Reviews Collection.

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MicroRNA and cancer

Nature Publishing Group presents a Collection on microRNAs and cancer, which includes original Research and Review articles, as well as Research Highlights from Nature Genetics, Nature Reviews Genetics and Nature Reviews Cancer. The collection is freely available until September 30th, 2008, thanks to the support from Exiqon.