Supplements
Cancer
In this supplement
Cancer research is progressing at a rapid pace. This collection highlights recent studies that increase our understanding of the complex biological processes underlying tumour development and progression. It also features novel approaches towards translating these advances into potential new anticancer drugs.
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Editorial
Editorial
Insights into the development of cancer - Free access
Barbara Marte
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Cancer collection
Article
Complex landscapes of somatic rearrangement in human breast cancer genomes
Philip J. Stephens et al.
Nature 462, 1005—1010 (24 December 2009) doi:10.1038/nature08645
Abstract | Full Text | PDF | Supplementary Information
Letter
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
Wenjun Zhou et al.
Nature 462, 1070—1074 (24 December 2009) doi:10.1038/nature08622
Abstract | Full Text | PDF | Supplementary Information
Article
Direct inhibition of the NOTCH transcription factor complex
Raymond E. Moellering et al.
Nature 462, 182—188 (12 November 2009) doi:10.1038/nature08543
Abstract | Full Text | PDF | Supplementary Information
Article
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
Nature 462, 739—744 (10 December 2009) doi:10.1038/nature08617
Abstract | Full Text | PDF | Supplementary Information
Article
Pten in stromal fibroblasts suppresses mammary epithelial tumours
Anthony J. Trimboli et al.
Nature 461, 1084—1091 (22 October 2009) doi:10.1038/nature08486
Abstract | Full Text | PDF | Supplementary Information
Letter
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
Sohrab P. Shah et al.
Nature 461, 809—813 (8 October 2009) doi:10.1038/nature08489
Abstract | Full Text | PDF | Supplementary Information
Letter
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
Silvia Buonamici et al.
Nature 459, 1000—1004 (18 June 2009) doi:10.1038/nature08020
Abstract | Full Text | PDF | Supplementary Information
Article
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Teresa A. Soucy et al.
Nature 458, 732—736 (9 April 2009) doi:10.1038/nature07884
Abstract | Full Text | PDF | Supplementary Information
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Other cancer research
Perspective
International network of cancer genome project
The International Cancer Genome Consortium
Nature 464, 993—998 (15 April 2010) doi:10.1038/nature08987
Letter
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta et al.
Nature 464, 1071—1076 (15 April 2010) doi:10.1038/nature08975
Letter
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis et al.
Nature 464, 1067—1070 (15 April 2010) doi:10.1038/nature08956
Letter
Migrastatin analogues target fascin to block tumour metastas
Lin Chen, Shengyu Yang, Jean Jakoncic, J. Jillian Zhang & Xin-Yun Huang
Nature 464, 1062—1066 (15 April 2010) doi:10.1038/nature08978
Letter
Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis
Ling Zhang et al.
Nature 464, 1058—1061 (15 April 2010) doi:10.1038/nature08871
Letter
Therapeutic antibody targeting of individual Notch receptors
Yan Wu et al.
Nature 464, 1052—1057 (15 April 2010) doi:10.1038/nature08878
Article
Genome remodelling in a basal-like breast cancer metastasis and xenograft
Li Ding et al.
Nature 464, 999—1005 (15 April 2010) doi:10.1038/nature08989
News and Views
Cancer: Genomics of metastasis
Joe Gray
Nature 464, 989—990 (15 April 2010) doi:10.1038/464989a
News and Views
Cancer: Drug-tolerant insurgents
Paul Workman & Jon Travers
Nature 464, 844—845 (8 April 2010) doi:10.1038/464844a
Letter
Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
Rocio Sotillo, Juan-Manuel Schvartzman, Nicholas D. Socci & Robert Benezra
Nature 464, 436—440 (18 March 2010) doi:10.1038/nature08803
Abstract | Full Text | PDF | Supplementary Information
Letter
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Georgia Hatzivassiliou et al.
Nature 464, 431—435 (18 March 2010) doi:10.1038/nature08833
Abstract | Full Text | PDF | Supplementary Information
Letter
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag, Kevan M. Shokat & Neal Rosen
Nature 464, 427—430 (18 March 2010) doi:10.1038/nature08902
Abstract | Full Text | PDF | Supplementary Information
Article
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
Hui-Kuan Lin et al.
Nature 464, 374—379 (18 March 2010) doi:10.1038/nature0881
Abstract | Full Text | PDF | Supplementary Information
News and Views
Cancer: A lower bar for senescence
Manuel Serrano
Nature 464, 363—364 (18 March 2010) doi:10.1038/464363a
News and Views
Drug discovery: Inhibitors that activate
Karen Cichowski & Pasi A. Jänne
Nature 464, 358—359 (18 March 2010) doi:10.1038/464358a
Article
The landscape of somatic copy-number alteration across human cancers
Rameen Beroukhim et al.
Nature 463, 899—905 (18 February 2010) doi:10.1038/nature08822
Abstract | Full Text | PDF | Supplementary Information
Article
Signatures of mutation and selection in the cancer genome
Graham R. Bignell et al.
Nature 463, 893—898 (18 February 2010) doi:10.1038/nature0876
Abstract | Full Text | PDF | Supplementary Information
Letter
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
Massimo Ammirante et al.
Nature 464, 302—305 (11 March 2010) doi:10.1038/nature08782
Abstract | Full Text | PDF | Supplementary Information
Letter
TGF-β-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
Kazuhito Naka et al.
Nature 463, 676—680 (4 February 2010) doi:10.1038/nature08734
Abstract | Full Text | PDF | Supplementary Information
Letter
Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion
Ming Wu, José Carlos Pastor-Pareja & Tian Xu
Nature 463, 545—548 (28 January 2010) doi:10.1038/nature08702
Abstract | Full Text | PDF | Supplementary Information
Article
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
Jianming Zhang et al.
Nature 463, 501—506 (28 January 2010) doi:10.1038/nature08675
Abstract | Full Text | PDF | Supplementary Information
Letter
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
Charles J. David, Mo Chen, Marcela Assanah, Peter Canoll & James L. Manley
Nature 463, 364—368 (21 January 2010) doi:10.1038/nature08697
Abstract | Full Text | PDF | Supplementary Information
Letter
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
Gillian L. Dalgliesh et al.
Nature 463, 360—363 (21 January 2010) doi:10.1038/nature08672
Abstract | Full Text | PDF | Supplementary Information
Article
The transcriptional network for mesenchymal transformation of brain tumours
Maria Stella Carro et al.
Nature 463, 318—325 (21 January 2010) doi:10.1038/nature08712
Abstract | Full Text | PDF | Supplementary Information
Article
A comprehensive catalogue of somatic mutations from a human cancer genome
Erin D. Pleasance et al.
Nature 463, 191—196 (14 January 2010) doi:10.1038/nature08658
Abstract | Full Text | PDF | Supplementary Information
Article
A small-cell lung cancer genome with complex signatures of tobacco exposure
Erin D. Pleasance et al.
Nature 463, 184—190 (14 January 2010) doi:10.1038/nature08629
Abstract | Full Text | PDF | Supplementary Information
Letter
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
Martin Schwickart et al.
Nature 463, 103—107 (7 January 2010) doi:10.1038/nature08646
Abstract | Full Text | PDF | Supplementary Information
Letter
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
R. Eric Davis et al.
Nature 463, 88—92 (7 January 2010) doi:10.1038/nature08638
Abstract | Full Text | PDF | Supplementary Information
Article
Parental origin of sequence variants associated with complex diseases
Augustine Kong et al.
Nature 462, 868—874 (17 December 2009) doi:10.1038/nature08625
Abstract | Full Text | PDF | Supplementary Information
Letter
Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region
Monica Gostissa et al.
Nature 462, 803—807 (10 December 2009) doi:10.1038/nature08633
Abstract | Full Text | PDF | Supplementary Information
News and Views
Chemical biology: A Notch above other inhibitors
Paramjit S. Arora & Aseem Z. Ansari
Nature 462, 171—173 (12 November 2009) doi:10.1038/462171a
Letter
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
David A. Barbie et al.
Nature 462, 108—112 (5 November 2009) doi:10.1038/nature08460
Abstract | Full Text | PDF | Supplementary Information
Letter
Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma
Etienne Meylan et al.
Nature 462, 104—107 (5 November 2009) doi:10.1038/nature08462
Abstract | Full Text | PDF | Supplementary Information
News and Views
Cancer: A tumour gene's fatal flaws
Julian Downward
Nature 462, 44—45 (5 November 2009) doi:10.1038/462044a
Article
A luminal epithelial stem cell that is a cell of origin for prostate cancer
Xi Wang et al.
Nature 461, 495—500 (24 September 2009) doi:10.1038/nature08361
Abstract | Full Text | PDF | Supplementary Information
Letter
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
Jennifer O. Lauchle et al.
Nature 461, 411—414 (17 September 2009) doi:10.1038/nature08279
Abstract | Full Text | PDF | Supplementary Information
Letter
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
Zachary T. Schafer et al.
Nature 461, 109—113 (3 September 2009) doi:10.1038/nature08268
Abstract | Full Text | PDF | Supplementary Information
News and Views
Cancer: The fat and the furious
Eyal Gottlieb
Nature 461, 44—45 (3 September 2009) doi:10.1038/461044a
Letter
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
Masashi Sanada et al.
Nature 460, 904—908 (13 August 2009) doi:10.1038/nature08240
Abstract | Full Text | PDF | Supplementary Information
News and Views
Cancer: More than kin and less than kind
Kevin Shannon & Mignon Loh
Nature 460, 804—807 (13 August 2009) doi:10.1038/460804a
Letter
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
Kwan-Hyuck Baek et al.
Nature 459, 1126—1130 (25 June 2009) doi:10.1038/nature08062
Abstract | Full Text | PDF | Supplementary Information
Article
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer
Kenneth L. Scott et al.
Nature 459, 1085—1090 (25 June 2009) doi:10.1038/nature08109
Abstract | Full Text | PDF | Supplementary Information
Letter
Genes that mediate breast cancer metastasis to the brain
Paula D. Bos et al.
Nature 459, 1005—1009 (18 June 2009) doi:10.1038/nature08021
Abstract | Full Text | PDF | Supplementary Information
Letter
Copy number variation at 1q21.1 associated with neuroblastoma
Sharon J. Diskin et al.
Nature 459, 987—991 (18 June 2009) doi:10.1038/nature08035
Abstract | Full Text | PDF | Supplementary Information
Letter
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
Gang G. Wang et al.
Nature 459, 847—851 (11 June 2009) doi:10.1038/nature08036
Abstract | Full Text | PDF | Supplementary Information
Letter
Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma
Mara Compagno et al.
Nature 459, 717—721 (4 June 2009) doi:10.1038/nature07968
Abstract | Full Text | PDF | Supplementary Information
Letter
Frequent inactivation of A20 in B-cell lymphomas
Motohiro Kato et al.
Nature 459, 712—716 (4 June 2009) doi:10.1038/nature07969
Abstract | Full Text | PDF | Supplementary Information
News and Views
Cancer: Melanoma troops massed
Paul H. Huang & Richard Marais
Nature 459, 336—337 (21 May 2009) doi:10.1038/459336a
Progress
Cytoplasmic functions of the tumour suppressor p53
Douglas R. Green & Guido Kroemer
Nature 458, 1127—1130 (30 April 2009) doi:10.1038/nature07986
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Archive
Article
Efficient tumour formation by single human melanoma cells
Elsa Quintana et al.
Nature 456, 593—598 (4 December 2008) doi:10.1038/nature07567
Abstract | Full Text | PDF | Supplementary Information
Letter
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Wenqiang Yu et al.
Nature 451, 202—206 (10 January 2008) doi:10.1038/nature06468
Abstract | Full Text | PDF | Supplementary Information
Letter
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Arun Sreekumar et al.
Nature 457, 910—914 (12 February 2009) doi:10.1038/nature07762
Abstract | Full Text | PDF | Supplementary Information
Letter
Regulation of ERBB2 by oestrogen receptor—PAX2 determines response to tamoxifen
Antoni Hurtado et al.
Nature 456, 663—666 (4 December 2008) doi:10.1038/nature07483
Abstract | Full Text | PDF | Supplementary Information
Letter
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
Sunhwa Kim et al.
Nature 457, 102—106 (1 January 2009) doi:10.1038/nature07623
Abstract | Full Text | PDF | Supplementary Information
Article
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network
Nature 455, 1061—1068 (23 October 2008) doi:10.1038/nature07385
Abstract | Full Text | PDF | Supplementary Information
Article
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
Timothy J. Ley et al.
Nature 456, 66—72 (6 November 2008) doi:10.1038/nature07485
Abstract | Full Text | PDF | Supplementary Information
Article
Somatic mutations affect key pathways in lung adenocarcinoma
Li Ding et al.
Nature 455, 1069—1075 (23 October 2008) doi:10.1038/nature07423
Abstract | Full Text | PDF | Supplementary Information
News and Views
Fresh target for cancer therapy
Raymond J. Deshaies
Nature 458, 709—710 (9 April 2009) doi:10.1038/458709a
News and Views
When restriction is good
Anne Brunet
Nature 458, 713—714 (9 April 2009) doi:10.1038/458713a
Review
The cancer genome
Michael R. Stratton, Peter J. Campbell & P. Andrew Futreal
Nature 458, 719—724 (9 April 2009) doi:10.1038/nature07943
Article
Tumours with PI3K activation are resistant to dietary restriction
Nada Y. Kalaany & David M. Sabatini
Nature 458, 725—731 (9 April 2009) doi:10.1038/nature07782
Abstract | Full Text | PDF | Supplementary Information
Letter
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Ping Gao et al.
Nature 458, 762—765 (9 April 2009) doi:10.1038/nature07823
Abstract | Full Text | PDF | Supplementary Information
Letter
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Chen Zhao et al.
Nature 458, 776—779 (9 April 2009) doi:10.1038/nature07737
Abstract | Full Text | PDF | Supplementary Information
Letter
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Maximilian Diehn et al.
Nature 458, 780—783 (9 April 2009) doi:10.1038/nature07733
Abstract | Full Text | PDF | Supplementary Information
Letter
Genetic architecture of mouse skin inflammation and tumour susceptibility
David A. Quigley et al.
Nature 458, 505—508 (26 March 2009) doi:10.1038/nature07683
Abstract | Full Text | PDF | Supplementary Information
Letter
Transcriptome sequencing to detect gene fusions in cancer
Christopher A. Maher et al.
Nature 458, 97—101 (5 March 2009) doi:10.1038/nature07638
Abstract | Full Text | PDF | Supplementary Information
Letter
Crypt stem cells as the cells-of-origin of intestinal cancer
Nick Barker et al.
Nature 457, 608—611 (29 January 2009) doi:10.1038/nature07602
Abstract | Full Text | PDF | Supplementary Information
Letter
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
Liqin Zhu et al.
Nature 457, 603—607 (29 January 2009) doi:10.1038/nature07589
Abstract | Full Text | PDF | Supplementary Information
Letter
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
Catherine D. Van Raamsdonk et al.
Nature 457, 599—602 (29 January 2009) doi:10.1038/nature07586
Abstract | Full Text | PDF | Supplementary Information
Letter
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Sandra Rebouissou et al.
Nature 457, 200—204 (8 January 2009) doi:10.1038/nature07475
Abstract | Full Text | PDF | Supplementary Information
Article
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
Andrea Viale et al.
Nature 457, 51—56 (1 January 2009) doi:10.1038/nature07618
Abstract | Full Text | PDF | Supplementary Information
Letter
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
Maria Barna et al.
Nature 456, 971—975 (18 December 2008) doi:10.1038/nature07449
Abstract | Full Text | PDF | Supplementary Information
Letter
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
Christian Stockmann et al.
Nature 456, 814—818 (11 December 2008) doi:10.1038/nature07445
Abstract | Full Text | PDF | Supplementary Information
Letter
A role for VEGF as a negative regulator of pericyte function and vessel maturation
Joshua I. Greenberg et al.
Nature 456, 809—813 (11 December 2008) doi:10.1038/nature07424
Abstract | Full Text | PDF | Supplementary Information
Article
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
Zhong Wang et al.
Nature 455, 1205—1209 (30 October 2008) doi:10.1038/nature07284
Abstract | Full Text | PDF | Supplementary Information
Letter
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
Hongwu Zheng et al.
Nature 455, 1129—1133 (23 October 2008) doi:10.1038/nature07443
Abstract | Full Text | PDF | Supplementary Information
Letter
Activating mutations in ALK provide a therapeutic target in neuroblastoma
Rani E. George et al.
Nature 455, 975—978 (16 October 2008) doi:10.1038/nature07397
Abstract | Full Text | PDF | Supplementary Information
Letter
Oncogenic mutations of ALK kinase in neuroblastoma
Yuyan Chen et al.
Nature 455, 971—974 (16 October 2008) doi:10.1038/nature07399
Abstract | Full Text | PDF | Supplementary Information
Letter
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
Isabelle Janoueix-Lerosey et al.
Nature 455, 967—970 (16 October 2008) doi:10.1038/nature07398
Abstract | Full Text | PDF | Supplementary Information
Article
Identification of ALK as a major familial neuroblastoma predisposition gene
Yaël P. Mossé et al.
Nature 455, 930—935 (16 October 2008) doi:10.1038/nature07261
Letter
The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network
Min Sup Song et al.
Nature 455, 813—817 (9 October 2008) doi:10.1038/nature07290
Abstract | Full Text | PDF | Supplementary Information
Letter
Modelling Myc inhibition as a cancer therapy
Laura Soucek et al.
Nature 455, 679—683 (2 October 2008) doi:10.1038/nature07260
Abstract | Full Text | PDF | Supplementary Information
Letter
E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
Erick J. Morris et al.
Nature 455, 552—556 (25 September 2008) doi:10.1038/nature07310
Abstract | Full Text | PDF | Supplementary Information
Letter
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
Ron Firestein et al.
Nature 455, 547—551 (25 September 2008) doi:10.1038/nature07179
Abstract | Full Text | PDF | Supplementary Information
Letter
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
Nature 455, 406—410 (18 September 2008) doi:10.1038/nature07275
Abstract | Full Text | PDF | Supplementary Information
Letter
Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis
Shidong Jia et al.
Nature 454, 776—779 (7 August 2008) doi:10.1038/nature07091
Abstract | Full Text | PDF | Supplementary Information
Letter
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tuomas Tammela et al.
Nature 454, 656—660 (31 July 2008) doi:10.1038/nature07083
Abstract | Full Text | PDF | Supplementary Information
Letter
IRF4 addiction in multiple myeloma
Arthur L. Shaffer et al.
Nature 454, 226—231 (10 July 2008) doi:10.1038/nature07064
Abstract | Full Text | PDF | Supplementary Information
Letter
Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype
Helene R. McMurray et al.
Nature 453, 1112—1116 (19 June 2008) doi:10.1038/nature06973
Abstract | Full Text | PDF | Supplementary Information
Article
PML targeting eradicates quiescent leukaemia-initiating cells
Keisuke Ito et al.
Nature 453, 1072—1078 (19 June 2008) doi:10.1038/nature07016
Abstract | Full Text | PDF | Supplementary Information
Letter
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
Wei Guo et al.
Nature 453, 529—533 (22 May 2008) doi:10.1038/nature06933
Abstract | Full Text | PDF | Supplementary Information
Letter
Vascular normalization in Rgs5-deficient tumours promotes immune destruction
Juliana Hamzah et al.
Nature 453, 410—414 (15 May 2008) doi:10.1038/nature06868
Abstract | Full Text | PDF | Supplementary Information
Letter
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Charles G. Mullighan et al.
Nature 453, 110—114 (1 May 2008) doi:10.1038/nature06866
Abstract | Full Text | PDF | Supplementary Information
Letter
Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
Ilaria Malanchi et al.
Nature 452, 650—653 (3 April 2008) doi:10.1038/nature06835
Abstract | Full Text | PDF | Supplementary Information
Letter
Tumour maintenance is mediated by eNOS
Kian-Huat Lim, Brooke B. Ancrile, David F. Kashatus & Christopher M. Counter
Nature 452, 646—649 (3 April 2008) doi:10.1038/nature06778
Abstract | Full Text | PDF | Supplementary Information
Letter
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Thorgeir E. Thorgeirsson et al.
Nature 452, 638—642 (3 April 2008) doi:10.1038/nature06846
Abstract | Full Text | PDF | Supplementary Information
Letter
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
Rayjean J. Hung et al.
Nature 452, 633—637 (3 April 2008) doi:10.1038/nature06885
Abstract | Full Text | PDF | Supplementary Information
Letter
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
Nature 452, 230—233 (13 March 2008) doi:10.1038/nature06734
Abstract | Full Text | PDF | Supplementary Information
Article
SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis
Hye-Jung Han, Jose Russo, Yoshinori Kohwi & Terumi Kohwi-Shigematsu
Nature 452, 187—193 (13 March 2008) doi:10.1038/nature06781
Abstract | Full Text | PDF | Supplementary Information
Letter
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
Wataru Sakai et al.
Nature 451, 1116—1120 (28 February 2008) doi:10.1038/nature06633
Abstract | Full Text | PDF | Supplementary Information
Letter
Resistance to therapy caused by intragenic deletion in BRCA2
Stacey L. Edwards et al.
Nature 451, 1111—1115 (28 February 2008) doi:10.1038/nature06548
Abstract | Full Text | PDF | Supplementary Information
Letter
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Zoltan Arany et al.
Nature 451, 1008—1012 (21 February 2008) doi:10.1038/nature06613
Abstract | Full Text | PDF | Supplementary Information
Letter
Identification of cells initiating human melanomas
Tobias Schatton et al.
Nature 451, 345—349 (17 January 2008) doi:10.1038/nature06489
Abstract | Full Text | PDF | Supplementary Information
Letter
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
Benjamin L. Ebert et al.
Nature 451, 335—339 (17 January 2008) doi:10.1038/nature06494
Abstract | Full Text | PDF | Supplementary Information
Article
Endogenous human microRNAs that suppress breast cancer metastasis
Sohail F. Tavazoie et al.
Nature 451, 147—152 (10 January 2008) doi:10.1038/nature06487
Abstract | Full Text | PDF | Supplementary Information
Letter
NUMB controls p53 tumour suppressor activity
Ivan N. Colaluca et al.
Nature 451, 76—80 (3 January 2008) doi:10.1038/nature06412
Abstract | Full Text | PDF | Supplementary Information
Letter
Trisomy represses ApcMin-mediated tumours in mouse models of Down's syndrome
Thomas E. Sussan, Annan Yang, Fu Li, Michael C. Ostrowski & Roger H. Reeves
Nature 451, 73—75 (3 January 2008) doi:10.1038/nature06446
Abstract | Full Text | PDF | Supplementary Information
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