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Nature 459, 336-337 (21 May 2009) | doi:10.1038/459336a; Published online 20 May 2009

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Cancer: Melanoma troops massed

Paul H. Huang1 & Richard Marais1

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In many cancers, regulation of specific signalling molecules goes awry, affecting a host of other proteins and cellular processes. Proteomics is a useful systemic approach for identifying such extensive effects.

In most Western countries, the incidence of melanoma — a form of skin cancer linked to exposure to sunlight — doubles roughly every decade. Early removal of melanoma lesions leads to a good prognosis, but the outlook for patients with advanced melanoma is often bleak owing to a lack of effective treatments.

  1. Paul H. Huang and Richard Marais are at the Institute of Cancer Research, London SW3 6JB, UK.
    Email: richard.marais@icr.ac.uk

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